2型糖尿病病程、血糖与周围神经、血管病变的相关性研究

Correlation Analysis of the Disease Course, Blood Glucose with Peripheral Neuropathy and Vasculopathy in Type 2 Diabetic Patients

摘要: 本研究旨在探讨2型糖尿病(T2DM)病程和血糖水平与周围神经和外周血管病变之间的关系，以了解它们对神经和血管的影响。通过回顾性研究，选择了2023年2月至2023年5月在青岛大学附属医院的148例T2DM患者，收集了他们的病程、空腹血糖、糖化血红蛋白、视网膜病变、下肢和颈部血管超声以及肌电图检查结果。使用SPSS 22软件进行数据相关性分析。结果显示，T2DM病程与神经传导速度呈负相关，与血管病变呈正相关；T2DM血糖水平与神经传导速度呈负相关，但与血管病变之间没有明显的相关性；下肢血管超声和视网膜病变与神经传导速度呈负相关。综上所述，T2DM病程越长，神经和血管病变越严重。高血糖并未明显引起血管病变，但会导致周围神经的损害，而血管病变会加重周围神经损害。

Abstract: Objective: The purpose of this study was to explore the correlation of the disease course, blood glu-cose level, peripheral neuropathy and vasculopathy in type 2 diabetic patients, so as to understand their effects on peripheral neuropathy and vasculopathy. Method: Through a retrospective study, 148 patients with T2DM who were admitted to the Affiliated Hospital of Qingdao University from February 2023 to May 2023 were selected, and their course of disease, fasting blood glucose, gly-cated hemoglobin, retinopathy, lower limb and neck vascular ultrasound, and electromyographic results were collected. Perform data correlation analysis using SPSS 22 software. Results: The dis-ease course of T2DM was negatively correlated with nerve conduction velocity and positively corre-lated with vascular lesions; there is a negative correlation between blood glucose and nerve con-duction velocity in T2DM, but there is no significant correlation with vascular disease; lower limb vascular ultrasound and retinopathy are negatively correlated with nerve conduction velocity. Con-clusion: The longer the disease course of T2DM, the more severe the neurological and vascular le-sions. Hyperglycemia does not significantly cause vascular damage, but can lead to damage to the peripheral nerves, which can be exacerbated by vascular damage.