复发性流产和长链非编码RNA的相关性分析
Correlation Analysis of Recurrent Abortion and Long Non-Coding RNA
DOI: 10.12677/ACM.2023.1392106, PDF,   
作者: 张 倩, 张雪妍：内蒙古医科大学第一临床医学院，内蒙古 呼和浩特；陈秀娟：内蒙古医科大学附属医院生殖医学中心，内蒙古 呼和浩特
关键词: 复发性流产；长链非编码RNA；蜕膜化；基因；Recurrent Abortion； Long Non-Coding RNA； Decidualization； Gene
摘要: 复发性流产(RSA)是女性不孕症中的一种复杂类型，其病因复杂，约50%的RSA患者病因不明，由于蜕膜化异常所致的反复流产成为学者关注的焦点。近年来长链非编码RNA (lncRNA)的研究快速兴起，由于其作用机制多样，且生物学功能更加强大，已成为表观遗传学领域一个新的研究热点。越来越多的研究报道lncRNA可通过调控靶基因的表达，从而参与女性生殖疾病的发生与发展。其中lncRNA与流产相关疾病机制的关系也逐渐受到学者的重视。本文就lncRNA与RSA之间的关系进行综述。
Abstract: Recurrent abortion (RSA) is a complex type of female infertility with a complex etiology, about 50% of RSA patients have unknown causes. Repeated abortions due to abnormal decidualization have become the focus of scholars. In recent years, the research of long non-coding RNA (lncRNA) has risen rapidly. It has become a new research hotspot in the field of epigenetics due to its diverse ac-tion mechanisms and more powerful biological functions. A growing number of studies have re-ported that lncRNA can participate in the occurrence and development of female reproductive dis-eases by regulating the expression of target genes. Among them, the relationship between lncRNA and abortion-related disease mechanism has been gradually valued by scholars. This review sum-marizes the relationship between lncRNA and RSA.
文章引用：张倩, 陈秀娟, 张雪妍. 复发性流产和长链非编码RNA的相关性分析[J]. 临床医学进展, 2023, 13(9): 15061-15065. https://doi.org/10.12677/ACM.2023.1392106

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