长链非编码RNA CASC19在肿瘤中的研究进展
Research Progress of Long Non-Coding RNA CASC19 in Tumors
DOI: 10.12677/ACM.2023.1392110, PDF,   
作者: 安凤凤：济宁医学院临床医学院，山东 济宁；马俊丽*：济宁医学院附属医院放疗科，山东 济宁
关键词: 肿瘤；LncRNA；癌症易感基因19；研究进展；Tumor； LncRNA； CASC19； Research Progress
摘要: 长链非编码RNA (lncRNA)是一种转录本长度更长的非编码RNA，其长度超过200个核苷酸，可以调节基因表达。因为lncRNA缺乏开放阅读框，所以不具有编码蛋白质的功能。已有一些报道说明了lncRNAs主要在表观修饰、转录、转录后水平调控基因表达，以此来影响肿瘤的进展，被认为是肿瘤的重要调节因子。LncRNA CASC19 (癌症易感基因19)在不同癌症中的表达增加已有不少报道，例如结直肠癌、肺癌和胰腺癌等多种恶性肿瘤。较多学者研究表明CASC19的高表达水平与肿瘤进展、预后以及放疗敏感性密切相关。本文概述了CASC19对不同肿瘤的影响和潜在临床效用的最新研究进展。LncRNA CASC19非常有希望成为治疗肿瘤的有效靶点和潜在的生物标志物，为肿瘤的治疗贡献一份力量。
Abstract: Long-chain non-encoding RNA (lncRNA) is a non-encoded RNA with a longer-length transcription book. Its length exceeds 200 nucleotides and can regulate gene expression. Because lncRNA lacks an open reading box, it does not have the function of encoding protein. Some reports have explained that lncRNAs is mainly used for the expression of horizontal regulatory genes after apparent modi-fication, transcription, and transcription, which affects the tumor and progress, and is considered an important regulatory factor for tumors. LncRNA CASC19 (Cancer Driver Gene 19) has been reported in different cancers, such as a variety of malignant tumors such as colorectal cancer, lung cancer, and pancreatic cancer. More scholars’ studies have shown that the high expression level of CASC19 is closely related to tumor progress, prognosis and radiotherapy sensitivity. This article outlines the latest research progress of CASC19 on different tumors and potential clinical utility. LncRNA CASC19 is very hopeful to become an effective target for the treatment of tumors and potential biomarkers, and contribute to the treatment of tumors.
文章引用：安凤凤, 马俊丽. 长链非编码RNA CASC19在肿瘤中的研究进展[J]. 临床医学进展, 2023, 13(9): 15092-15098. https://doi.org/10.12677/ACM.2023.1392110

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