基于数据挖掘技术探索突发性耳聋的用药规律

To Explore Medication Rules of Sudden Deafness Based on Data Mining Technology

摘要: 目的：目前，尚无人对当代医家处方治疗突发性耳聋(SD)进行经验总结，遂利用数据挖掘技术探索当代医家治疗SD的用药规律并进行总结、分析、古今对比，望为中医治疗突发性耳聋提供新方向。方法：通过检索主题词“突发性耳聋”“中医”收集整理中国知网(CNKI)、万方数据知识服务平台(Wan Fang)、维普数据库(VIP)建库以来至2022年9月中医治疗SD的期刊，建立处方数据库，利用数据挖掘技术进行频数分析、性味归经及功效分析、关联规则分析和聚类分析，探索中医治疗SD的用药规律。结果：筛选到文献268篇，其中包含处方216首，中药242味，药物使用总频次为2537次。常用的药物为川芎、石菖蒲、柴胡、甘草、当归；常用的功效为补虚、活血化瘀、解表、清热；药性以寒、温为主；药味以苦、甘、平为主；归经以肝、心、肺、脾为主。常用药物关联规则分析得到强关联药对10对，聚类分成5类。结论：中医治疗SD以活血化瘀药、解表药、开窍药为主，药性偏寒温，药味偏苦甘平，归经主要为肝心肺脾。聚类分析从另一个角度肯定了龙胆泻肝汤在SD治疗中的突出作用，发现4个有药理学和经方支持的新方。

Abstract: Objective: At present, there is no experience summary of the treatment of sudden deafness (SD) by contemporary doctors. Therefore, data mining technology is used to explore the medication rules of contemporary doctors in the treatment of sudden deafness (SD), summarize, analyze, and compare ancient and modern, so as to provide a new direction for the treatment of sudden deafness with tra-ditional Chinese medicine. Methods: By searching the subject words of “sudden deafness” and “tra-ditional Chinese medicine”, the journals of sudden deafness treated by traditional Chinese medicine were collected from China National Knowledge Infrastructure (CNKI), Wan Fang Data Knowledge Service platform (Wan Fang) and VIP database from the establishment of databases to September 2022, and a prescription database was established. Data mining technology was used to conduct frequency analysis, property and taste tropism and efficacy analysis, association rule analysis and cluster analysis to explore the medication rules of sudden deafness of traditional Chinese medicine. Results: A total of 268 articles were screened, including 216 prescriptions and 242 Chinese herbs. The total frequency of drug use was 2537 times. The commonly used drugs were Chuanxiong, Shichangpu, Chaihu, Gancao and Danggui. The commonly used functions are tonifying deficiency, promoting blood circulation, removing blood stasis, relieving surface and clearing heat. Its proper-ties were mainly cold and warm. The medicinal flavor was mainly bitter, sweet and flat. The main meridians were liver, heart, lung and spleen. The analysis of common drug association rules ob-tained 10 pairs of strong association drugs, which were clustered into 5 categories. Conclusion: In the treatment of SD, traditional Chinese medicine (TCM) is mainly used to promote blood circulation and dissipate blood stasis, relieve surface and open orifices. The medicinal properties are cold and warm, the taste is bitter and smooth, and the meridians are mainly liver, heart, lung and spleen. Cluster analysis confirmed the prominent role of Longdanxiegan decoction in the treatment of SD from another perspective, and found 4 new prescriptions supported by pharmacology and classical prescriptions.