2型糖尿病认知功能障碍与脑胰岛素抵抗的研究进展
Research Progress of Cognitive Dysfunction and Brain Insulin Resistance in Type 2 Diabetes Mellitus
DOI: 10.12677/ACM.2023.1392115, PDF,   
作者: 赵一霖:华北理工大学研究生学院,河北 唐山;房 辉*:唐山工人医院内分泌二科,河北 唐山
关键词: 2型糖尿病认知障碍发病机制研究进展Type 2 Diabetes Mellitus Cognitive Impairment Pathogenesis Research Progress
摘要: 胰岛素抵抗(IR)是2型糖尿病(type 2 diabetes mellitus, T2DM)发生的主要机制,甚至在认知障碍的整个发生和后续发展上都发挥着重要的作用。本文通过阐述胰岛素抵抗对诱发2型糖尿病的机制,进而导致糖尿病认知障碍,并提出防治手段提供参考,为2型糖尿病认知障碍所需要的药物奠定开发新思路和基础。
Abstract: Insulin resistance (IR) is the main mechanism of type 2 diabetes mellitus (T2DM), and even plays an important role in the whole occurrence and subsequent development of cognitive impairment. This article elaborates on the mechanism of insulin resistance in inducing type 2 diabetes, which leads to cognitive impairment of diabetes, and puts forward the prevention and treatment methods to provide reference, so as to lay new ideas and foundation for the development of drugs needed for cognitive impairment of type 2 diabetes.
文章引用:赵一霖, 房辉. 2型糖尿病认知功能障碍与脑胰岛素抵抗的研究进展[J]. 临床医学进展, 2023, 13(9): 15128-15132. https://doi.org/10.12677/ACM.2023.1392115

参考文献

[1] Saeedi, P., Petersohn, I., Salpea, P., et al. (2019) Global and Regional Diabetes Prevalence Estimates for 2019 and Pro-jections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th Edition. Diabetes Re-search and Clinical Practice, 157, Article ID: 107843. [Google Scholar] [CrossRef] [PubMed]
[2] 王天歌, 陆洁莉, 毕宇芳, 等. 中国糖尿病持续攀升新解: 中年肥胖相关胰岛素抵抗成为主要威胁[J]. 中华内分泌代谢杂志, 2020, 36(3): 198-200.
[3] Sripetchwandee, J., Chattipakorn, N. and Chattipakorn, S.C. (2018) Links between Obe-sity-Induced Brain Insulin Resistance, Brain Mitochondrial Dysfunction, and Dementia. Frontiers in Endocrinology, 9, Article 496. [Google Scholar] [CrossRef] [PubMed]
[4] 刘舟, 李月碧, 张卫华, 等. 黄连温胆汤对糖尿病大鼠海马胰岛素抵抗和神经发生受损的改善作用[J]. 中国实验方剂学杂志, 2015, 21(18): 115-119.
[5] 李琛, 梁兴伦, 周文锐, 等. 老年2型糖尿病患者轻度认知功能障碍与胰岛素抵抗的关系研究[J]. 临床和实验医学杂志, 2014(16): 1369-1371.
[6] Henquin, J.C. (2009) Regulation of Insulin Secretion: A Matter of Phase Control and Amplitude Mod-ulation. Diabetologia, 52, 739-751. [Google Scholar] [CrossRef] [PubMed]
[7] Rhea, E.M. and Banks, W.A. (2019) Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance. Frontiers in Neuroscience, 13, Article 521. [Google Scholar] [CrossRef] [PubMed]
[8] Werner, H. and Leroith, D. (2014) Insulin and Insu-lin-Like Growth Factor Receptors in the Brain: Physiological and Pathological Aspects. European Neuropsychophar-macology, 24, 1947-1953. [Google Scholar] [CrossRef] [PubMed]
[9] Heni, M., Schöpfer, P., Peter, A., et al. (2014) Evidence for Altered Transport of Insulin across the Blood-Brain Barrier in Insulin-Resistant Humans. Acta Diabetologica, 51, 679-681. [Google Scholar] [CrossRef] [PubMed]
[10] Kimura, N. (2016) Diabetes Mellitus Induces Alz-heimer’s Disease Pathology: Histopathological Evidence from Animal Models. International Journal of Molecular Sci-ences, 17, Article No. 503. [Google Scholar] [CrossRef] [PubMed]
[11] Rotermund, C., Truckenmuller, F.M., Schell, H. and Kahle, P.J. (2014) Diet-Induced Obesity Accelerates the Onset of Terminal Phenotypes in Al-pha-Synuclein Transgenic Mice. Journal of Neurochemistry, 131, 848-858. [Google Scholar] [CrossRef] [PubMed]
[12] Nation, D.A., Sweeney, M.D., Montagne, A., et al. (2019) Blood-Brain Barrier Breakdown Is an Early Biomarker of Human Cognitive Dysfunction. Nature Medicine, 25, 270-276. [Google Scholar] [CrossRef] [PubMed]
[13] Desilles, J.-P., Syvannarath, V., Ollivier, V., et al. (2017) Exac-erbation of Thromboinflammation by Hyperglycemia Precipitates Cerebral Infarct Growth and Hemorrhagic Transfor-mation. Stroke, 48, 1932-1940. [Google Scholar] [CrossRef
[14] Zhao, Z., Hu, J., Gao, X., et al. (2017) Hyperglycemia via Activation of Thromboxane A2 Receptor Impairs the Integrity and Function of Blood-Brain Barrier in Microvascular Endothelial Cells. Oncotarget, 8, 30030-30038. [Google Scholar] [CrossRef] [PubMed]
[15] Scheltens, P., Blennow, K., Breteler, M.M., et al. (2016) Alz-heimer’s Disease. Lancet, 388, 505-517. [Google Scholar] [CrossRef
[16] Bejanin, A., Schonhaut, D.R., La Joie, R., et al. (2017) Tau Pathology and Neurodegeneration Contribute to Cognitive Impairment in Alzheimer’s Disease. Brain, 140, 3286-3300. [Google Scholar] [CrossRef] [PubMed]
[17] Sajan, M., Hansen, B., Ivey 3rd, R., et al. (2016) Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phos-pho-Tau May Abet Alzheimer Development. Diabetes, 65, 1892-1903. [Google Scholar] [CrossRef] [PubMed]
[18] Moran, C., Beare, R., Phan, T.G., et al. (2015) Type 2 Diabetes Mellitus and Biomarkers of Neurodegeneration. Neurology, 85, 1123-1130. [Google Scholar] [CrossRef
[19] Moreno, C.L., Della Guardia, L., Shnyder, V., et al. (2018) iPSC-Derived Familial Alzheimer’s PSEN2N141I Cholinergic Neurons Exhibit Mutation-Dependent Molecular Pathology Corrected by Insulin Signaling. Molecular Neurodegeneration, 13, Article No. 33. [Google Scholar] [CrossRef] [PubMed]
[20] Yang, Y., Kimura-Ohba, S., Thompson, J. and Rosenberg, G.A. (2016) Rodent Models of Vascular Cognitive Impairment. Translational Stroke Research, 7, 407-414. [Google Scholar] [CrossRef] [PubMed]
[21] Coucha, M., Abdelsaid, M., Ward, R., Abdul, Y. and Ergul, A. (2018) Impact of Metabolic Diseases on Cerebral Circulation: Structural and Functional Consequences. In: Terjung, R., Ed., Comprehensive Physiology, Vol. 8, Wiley, Hoboken, 773-799. [Google Scholar] [CrossRef] [PubMed]
[22] Schubert, C.R., Fischer, M.E., Pinto, A.A., et al. (2019) Brain Aging in Midlife: The Beaver Dam Offspring Study. Journal of the American Geriatrics Society, 67, 1610-1616. [Google Scholar] [CrossRef] [PubMed]
[23] Bozluolcay, M., Andican, G., Fırtına, S., Erkol, G., and Konukoglu, D. (2016) Inflammatory Hypothesis as a Link between Alzheimer’s Disease and Diabetes Mellitus. Geriatrics & Gerontol-ogy International, 16, 1161-1166. [Google Scholar] [CrossRef] [PubMed]
[24] Wennberg, A.M.V., Hagen, C.E., Machulda, M.M., et al. (2019) The Cross-Sectional and Longitudinal Associations between IL-6, IL-10, and TNFα and Cognitive Outcomes in the Mayo Clinic Study of Aging. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 74, 1289-1295. [Google Scholar] [CrossRef] [PubMed]
[25] Yaffe, K., Lindquist, K., Schwartz, A.V., et al. (2011) Advanced Gly-cation End Product Level, Diabetes, and Accelerated Cognitive Aging. Neurology, 77, 1351-1356. [Google Scholar] [CrossRef
[26] Béland-Millar, A., Takimoto, M., Hamada, T., et al. (2020) Brain and Muscle Adaptation to High-Fat Diets and Exercise: Metabolic Transporters, Enzymes and Substrates in the Rat Cortex and Muscle. Brain Research, 1749, Article ID: 147126. [Google Scholar] [CrossRef] [PubMed]
[27] Fazakerley, D.J., Minard, A.Y., Krycer, J.R., et al. (2018) Mi-tochondrial Oxidative Stress Causes Insulin Resistance without Disrupting Oxidative Phosphorylation. The Journal of Biological Chemistry, 293, 7315-7328. [Google Scholar] [CrossRef
[28] Hussain, Y., Jain, S.K. and Samaiya, P.K. (2019) Short-Term Westernized (HFFD) Diet Fed in Adolescent Rats: Effect on Glucose Homeostasis, Hippocampal Insulin Signaling, Apoptosis and Related Cognitive and Recognition Memory Function. Behavioural Brain Research, 361, 113-121. [Google Scholar] [CrossRef] [PubMed]
[29] 鲍雷, 蔡夏夏, 张明远, 任磊磊. 维生素D3对2型糖尿病小鼠轻度认知障碍的改善作用及机制研究[J]. 北京大学学报(医学版), 2023, 55(4): 587-592.
[30] 郭伟, 李伟, 彭聪, 谢海鹰. 西格列汀对2型糖尿病患者轻度认知功能障碍的影响[J]. 武汉大学学报(医学版), 2021, 42(1): 123-127.
[31] 孙洁. 胰岛素降解酶介导胰岛素抵抗所致2型糖尿病轻度认知功能障碍的机制研究[D]: [博士学位论文]. 南京: 东南大学, 2018.
[32] 章秋, 代芳. 关注糖尿病患者的认知功能障碍[J]. 中国全科医学, 2016, 19(2): 130-134.