急性心肌梗死患者泛免疫炎症指数及预后营养指数与冠脉狭窄程度的相关性

Correlation of Pan-Immune Inflammatory Index and Prognostic Nutritional Index with Coronary Stenosis Degree in Patients with Acute Myocardial Infarction

摘要: 目的：探讨泛免疫炎症值(PIV)及预后营养指数(PNI)与急性心肌梗死(AMI)患者冠状动脉狭窄程度的关系。方法：收集2021年4月~2023年4月于石河子大学第一附属医院就诊且在发病12 h内行冠状动脉造影(CAG)的AMI患者443例，收集临床资料及CAG结果，并根据Gensini评分分为GS低分组(<35分；N = 146)、GS中分组(<60分；N = 143)与GS高分组(≥60分；N = 154)，进行组间比较。采用Spearman相关性分析和多元线性回归模型评估PIV和PNI与AMI患者冠脉狭窄严重程度的相关性。结果：不同Gensini评分三组间PIV、PNI水平有显著差异(P < 0.05)。Gensini评分及冠脉病变受累血管支数与PIV呈正相关(P < 0.05)，与PNI呈负相关(P < 0.01)，且PIV、PNI均与Gensini评分独立相关(P < 0.05)。结论：PIV和PNI均与AMI患者冠脉狭窄程度及冠脉病变受累血管支数呈正相关，可进行AMI患者冠脉病变程度的初步评估。

Abstract: Objective: To explore the relationship between the degree of coronary artery stenosis in patients with acute myocardial infarction (AMI) with pan immune inflammatory value (PIV) and prognostic nutritional index (PNI). Method: 443 patients with AMI who received treatment at the First Affili-ated Hospital of Shihezi University from April 2021 to April 2023 were collected for coronary angi-ography (CAG) within 12 hours of onset. Clinical data and CAG results were collected and according to the Gensini score divided into a low GS group (<35 points, N = 146), a medium GS group (<60 points; N = 143), and a high GS group (≥60 points; N = 154), and compared between the groups. We use Spearman correlation analysis and multiple linear regression models to evaluate the correla-tion between PIV and PNI in AMI patients and the severity of coronary artery stenosis. Result: There was a statistically significant difference in PIV and PNI levels among the three groups with different Gensini scores (P < 0.05). Gensini score and the number of involved vessels were positively corre-lated with PIV (P < 0.05) and negatively correlated with PNI (P < 0.01), and PIV and PNI were inde-pendently correlated with Gensini score (P < 0.05). Conclusion: Both PIV and PNI are positively cor-related with the degree of coronary artery stenosis and the number of involved vessels in patients with AMI, which can be used for preliminary assessment of the degree of coronary artery disease in patients with AMI.