炎症在基于冠状动脉粥样硬化的急性冠脉综合征中的作用
The Role of Inflammation in Acute Coronary Syndromes Based on Coronary Atherosclerosis
DOI: 10.12677/ACM.2023.13102144, PDF,   
作者: 赵 鹏, 刘志强：新疆医科大学第一附属医院综合心脏内科，新疆 乌鲁木齐
关键词: 急性冠脉综合征；冠状动脉粥样硬化；炎症；Acute Coronary Syndrome； Coronary Atherosclerosis； Inflammation
摘要: 急性冠脉综合征(ACS)是全球急性死亡的主要原因之一，虽然非动脉粥样硬化因素也可导致ACS，但ACS最常见的原因是动脉粥样硬化斑块破裂或糜烂，随后形成血栓。动脉粥样硬化是一种慢性炎症性疾病，其中免疫系统在其发展和进展中起着重要作用。炎症诱发的内皮功能障碍导致脂蛋白通透性增加及其内皮下积聚、白细胞募集和血小板活化，从而形成动脉粥样硬化。但在慢性炎症的情况下，巨噬细胞同时会对纤维帽产生分解代谢作用，导致薄帽纤维动脉粥样硬化，使斑块脆弱，若发生免疫和炎症功能障碍，免疫和炎症功能障碍，促动脉粥样硬化和抗动脉粥样硬化免疫网络的不平衡促进斑块从稳定状态转变为不稳定状态，并导致急性冠状动脉事件的发生。
Abstract: Acute coronary syndrome (ACS) is one of the leading causes of acute death worldwide. Although non-atherosclerotic factors can also cause ACS, the most common cause of ACS is the rupture or ero-sion of atherosclerotic plaques followed by the formation of blood clots. Atherosclerosis is a chronic inflammatory disease in which the immune system plays an important role in its development and progression. Inflammation induced endothelial dysfunction leads to increased permeability of lipo-proteins and their subcutaneous accumulation, leukocyte recruitment and platelet activation, re-sulting in atherosclerosis. However, in the case of chronic inflammation, macrophages will also have catabolic effects on the fiber cap, leading to atherosclerosis of the thin cap fiber and making the plaque fragile. If immune and inflammatory dysfunction occurs, the imbalance of the pro-atherosclerosis and anti-atherosclerosis immune network promotes the plaque to change from a stable state to an unstable state and lead to acute coronary events.
文章引用：赵鹏, 刘志强. 炎症在基于冠状动脉粥样硬化的急性冠脉综合征中的作用[J]. 临床医学进展, 2023, 13(10): 15323-15328. https://doi.org/10.12677/ACM.2023.13102144

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