系统性红斑狼疮相关炎症指标的研究进展
Research Progress on Inflammatory Indicators Related to Systemic Lupus Erythematosus
DOI: 10.12677/ACM.2023.13102149, PDF,   
作者: 任 惠*：青海大学研究生院，青海 西宁；张 翔*：青海大学研究生院，青海 西宁；青海大学附属医院检验科，青海 西宁
关键词: 系统性红斑狼疮；免疫细胞；炎症细胞因子；常用临床实验室检查；Systemic Lupus Erythematosus； Immune Cells； Inflammatory Cytokines； Commonly Used Clinical Laboratory Tests
摘要: 系统性红斑狼疮(systemic lupus erythematosus, SLE)是累及多器官多系统的一种自身免疫性疾病，其病因未明，发病机制复杂，临床表现多种多样。相关研究表明，部分炎症指标的异常可能对SLE的诊断及活动度的判断有一定的帮助。本文将从部分炎症标志物的异常阐述对SLE的影响，旨在更好地对SLE的早期诊断提供资料支持，从而为SLE的治疗提供新的思路。
Abstract: Systemic lupus erythematosus is an autoimmune disease involving multiple organs and systems, with unknown etiology, complex pathogenesis, and diverse clinical manifestations. Relevant studies have shown that abnormalities in some inflammatory indicators may be helpful in the diagnosis of SLE and the determination of mobility. This article will explain the impact of some abnormalities of inflammatory markers on SLE, aiming to provide better data support for the early diagnosis of SLE, so as to provide new ideas for the treatment of SLE.
文章引用：任惠, 张翔. 系统性红斑狼疮相关炎症指标的研究进展[J]. 临床医学进展, 2023, 13(10): 15354-15360. https://doi.org/10.12677/ACM.2023.13102149

参考文献

[1] Aringer, M., Costenbader, K., Daikh, D., et al. (2019) 2019 European League against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. Annals of the Rheumatic Diseases, 78, 1151-1159. [Google Scholar] [CrossRef] [PubMed]
[2] Aringer, M. (2020) Inflammatory Markers in Systemic Lupus Erythematosus. Journal of Autoimmunity, 110, Article ID: 102374. [Google Scholar] [CrossRef] [PubMed]
[3] Fousert, E., Toes, R. and Desai, J. (2020) Neutrophil Extracellular Traps (NETs) Take the Central Stage in Driving Autoimmune Responses. Cells, 9, Article 915. [Google Scholar] [CrossRef] [PubMed]
[4] Lee, K.H., Kronbichler, A., Park, D.D., et al. (2017) Neutrophil Extra-cellular Traps (NETs) in Autoimmune Diseases: A Comprehensive Review. Autoimmunity Reviews, 16, 1160-1173. [Google Scholar] [CrossRef] [PubMed]
[5] Xiang, S., Zhang, J., Zhang, M., et al. (2022) Imbalance of Help-er T Cell Type 1, Helper T Cell Type 2 and Associated Cytokines in Patients with Systemic Lupus Erythematosus: A Meta-Analysis. Frontiers in Pharmacology, 13, Article 988512. [Google Scholar] [CrossRef] [PubMed]
[6] Paredes, J.L., Fernandez-Ruiz, R. and Niewold, T.B. (2021) T Cells in Systemic Lupus Erythematosus. Rheumatic Disease Clinics, 47, 379-393. [Google Scholar] [CrossRef] [PubMed]
[7] Munoz-Urbano, M., Quintero-Gonzalez, D.C. and Vasquez, G. (2022) T Cell Metabolism and Possible Therapeutic Targets in Systemic Lupus Erythematosus: A Narrative Review. Immunopharmacology and Immunotoxicology, 44, 457-470. [Google Scholar] [CrossRef] [PubMed]
[8] Robinson, G.A., Wilkinson, M.G.L. and Wincup, C. (2021) The Role of Immunometabolism in the Pathogenesis of Systemic Lupus Erythematosus. Frontiers in Immunology, 12, Article 806560. [Google Scholar] [CrossRef] [PubMed]
[9] You, X., Zhang, R., Shao, M., et al. (2020) Double Negative B Cell Is Associated with Renal Impairment in Systemic Lupus Erythematosus and Acts as a Marker for Nephritis Remis-sion. Frontiers in Medicine, 7, Article 85. [Google Scholar] [CrossRef] [PubMed]
[10] Wang, T., Mei, Y. and Li, Z. (2019) Research Progress on Regula-tory B Cells in Systemic Lupus Erythematosus. BioMed Research International, 2019, Article ID: 7948687. [Google Scholar] [CrossRef] [PubMed]
[11] Firizal, A.S., Sugianli, A.K. and Hamijoyo, L. (2020) Cut off Point of Neutrophil-to-Lymphocyte Ratio as a Marker of Active Disease in Systemic Lupus Erythematosus. Lupus, 29, 1566-1570. [Google Scholar] [CrossRef] [PubMed]
[12] Li, Z., Xiao, Y. and Zhang, L. (2020) Application of Procalcitonin, White Blood Cell Count and Neutrophil-to-Lymphocyte Ratio in the Diagnosis of Systemic Lupus Ery-thematosus with a Bacterial Infection. Annals of Palliative Medicine, 9, 3870-3876. [Google Scholar] [CrossRef] [PubMed]
[13] Ma, L., Zeng, A., Chen, B., et al. (2019) Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Patients with Systemic Lupus Erythematosus and Their Correlation with Activ-ity: A Meta-Analysis. International Immunopharmacology, 76, Article ID: 105949. [Google Scholar] [CrossRef] [PubMed]
[14] Jin, S.Y., Yu, C.C. and Yu, B.W. (2021) Changes of Serum IL-6, IL-10 and TNF-α Levels in Patients with Systemic Lupus Erythematosus and Their Clinical Value. American Journal of Translational Research, 13, 2867-2874.
[15] Xiang, M., Feng, Y., Wang, Y., et al. (2021) Correlation be-tween Circulating Interleukin-18 Level and Systemic Lupus Erythematosus: A Meta-Analysis. Scientific Reports, 11, Ar-ticle No. 4707. [Google Scholar] [CrossRef] [PubMed]
[16] Liang, R., Zheng, L., Ji, T., et al. (2022) Elevated Serum Free IL-18 in Neuropsychiatric Systemic Lupus Erythematosus Patients with Seizure Disorders. Lupus, 31, 187-193. [Google Scholar] [CrossRef] [PubMed]
[17] Liu, W., Zhang, S. and Wang, J. (2022) IFN-γ, Should Not Be Ignored in SLE. Frontiers in Immunology, 13, Article 954706. [Google Scholar] [CrossRef] [PubMed]
[18] Oke, V., Gunnarsson, I., Dorschner, J., et al. (2019) High Levels of Circulating Interferons Type I, Type II and Type III Associate with Distinct Clinical Features of Active Systemic Lu-pus Erythematosus. Arthritis Research & Therapy, 21, Article No. 107. [Google Scholar] [CrossRef] [PubMed]
[19] Ghafouri-Fard, S., Shahir, M., Taheri, M. and Salimi, A. (2021) A Review on the Role of Chemokines in the Pathogenesis of Systemic Lupus Erythematosus. Cytokine, 146, Article ID: 155640. [Google Scholar] [CrossRef] [PubMed]
[20] Ayano, M. and Horiuchi, T. (2023) Complement as a Biomarker for Systemic Lupus Erythematosus. Biomolecules, 13, Article 367. [Google Scholar] [CrossRef] [PubMed]
[21] Weinstein, A., Alexander, R.V. and Zack, D.J. (2021) A Review of Complement Activation in SLE. Current Rheumatology Reports, 23, Article No. 16. [Google Scholar] [CrossRef] [PubMed]
[22] El-Serougy, E., Zayed, H., Ibrahim, N.M. and Maged, L.A. (2019) Procalcitonin and C-Reactive Protein as Markers of Infection in Systemic Lupus Erythematosus: The Controversy Continues. Lupus, 28, 1329-1336. [Google Scholar] [CrossRef] [PubMed]
[23] Littlejohn, E., Marder, W., Lewis, E., et al. (2018) The Ratio of Erythrocyte Sedimentation Rate to C-Reactive Protein Is Useful in Distinguishing Infection from Flare in Systemic Lupus Erythematosus Patients Presenting with Fever. Lupus, 27, 1123-1129. [Google Scholar] [CrossRef] [PubMed]
[24] Wang, C.M., Deng, J.H., Mao, G.F., et al. (2020) Serum Amy-loid A: A Potential Biomarker Assessing Disease Activity in Systemic Lupus Erythematosus. Medical Science Monitor, 26, e923290. [Google Scholar] [CrossRef] 
[25] Zhao, L., Zhang, Q., Feng, Z., et al. (2022) Serum Am-yloid A-to-Albumin Ratio as a Potential Biomarker to Predict the Activity, Severity, and Poor Prognosis of Systemic Lupus Erythematosus. Journal of Clinical Laboratory Analysis, 36, e24282. [Google Scholar] [CrossRef] [PubMed]
[26] Sumova, B., Cerezo, L.A., Szczukova, L., et al. (2019) Circulating S100 Proteins Effectively Discriminate SLE Patients from Healthy Controls: A Cross-Sectional Study. Rheumatology Interna-tional, 39, 469-478. [Google Scholar] [CrossRef] [PubMed]
[27] Tydén, H., Lood, C., Gullstrand, B., et al. (2017) Pro-Inflammatory S100 Proteins Are Associated with Glomerulonephritis and Anti-dsDNA Antibodies in Systemic Lu-pus Erythematosus. Lupus, 26, 139-149. [Google Scholar] [CrossRef] [PubMed]
[28] Kim, J.W., Jung, J.Y., Lee, S.W., et al. (2022) S100A8 in Serum, Urine, and Saliva as a Potential Biomarker for Systemic Lupus Erythematosus. Frontiers in Immunology, 13, Article 886209. [Google Scholar] [CrossRef] [PubMed]
[29] Wang, J., Niu, R., Jiang, L., et al. (2019) The Diagnostic Values of C-Reactive Protein and Procalcitonin in Identifying Systemic Lupus Erythematosus Infection and Disease Ac-tivity. Medicine, 98, e16798. [Google Scholar] [CrossRef] 

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