一个由原位反应制备的三维Pb(II)配合物及其在抗生素传感识别领域的应用
A Three-Dimensional Pb(II) Complex Prepared by In-Situ Reaction and Its Application in the Field of Antibiotic Sensing Recognition
DOI: 10.12677/AMC.2023.114010, PDF,   
作者: 孙阳宇, 汪兴淳, 郝小瑄, 罗万江, 袁 刚*：通化师范学院化学学院，吉林 通化；张 超：通化县第七中学化学组，吉林 通化
关键词: Pb(II)配合物；咪唑羧酸；原位反应；晶体结构；荧光传感；抗生素；Pb(II) Complex； Imidazole Carboxylic Acid； In-Situ Reaction； Crystal Structure； Fluorescence Sensing； Antibiotic
摘要: 在水热条件下使用半刚性的咪唑-4,5-二甲酸衍生物配体(H3L-1)和金属Pb(II)离子通过自组装反应成功获得一种无色的针状晶体。单晶X-射线衍射分析显示该配合物分子式为[Pb(L)]n (1)，其中初始的H3L-1配体在高温条件下脱去了一个羧基形成了L2‒形式，L2‒阴离子μ3-链接金属Pb(II)离子而形成了三维框架结构。拓扑分析显示配合物1的骨架是一个单节点的(3,3)-连接网络。配合物的晶相纯度，化学稳定性和热稳定性通过粉末X-射线衍射(PXRD)和热失重分析(TGA)等手段进行了表征。对配合物1的固态荧光性质进行了测定，结果显示配合物1是一种具有潜在应用价值的蓝光材料。此外，还对配合物1荧光传感性能进行了详细研究，测试多种常见的抗生素分子对配合物1荧光的影响，结果显示配合物1的荧光能够被以呋喃妥因(NFT)为代表的几种抗生素所猝灭，可作为检测这些抗生素分子的探针材料。
Abstract: A colorless acicular crystal was obtained by the self-assembly reaction of semi-rigid imidazole-4, 5-dicarboxylic acid derivative ligand (H3L-1) and metal Pb(II) ions under hydrothermal conditions. Single crystal X-ray diffraction analysis shows that the molecular formula of the complex is [Pb(L)]n (1), where the initial H3L-1 ligand removes a carboxyl group at high temperature to form L2‒ form, and L2‒ anions μ3-link metal Cd(II) ions to form a three-dimensional framework. Topological analysis shows that the framework of complex 1 is a single node (3,3)-connected network. The crystal purity, chemical stability and thermal stability of complex 1 were characterized by powder X-ray diffrac-tion (PXRD) and thermogravimetric analysis (TGA). The solid fluorescence properties of complex 1 were determined. The results showed that complex 1 is a kind of blue light material with potential application value. In addition, the fluorescence sensing properties of complex 1 were studied in de-tail, and the effects of many common antibiotic molecules on the fluorescence of complex 1 were tested. The results showed that the fluorescence of complex 1 can be quenched by several antibiot-ics represented by NFT, and can be used as probe materials for detecting these antibiotic molecules.
文章引用：孙阳宇, 张超, 汪兴淳, 郝小瑄, 罗万江, 袁刚. 一个由原位反应制备的三维Pb(II)配合物及其在抗生素传感识别领域的应用[J]. 材料化学前沿, 2023, 11(4): 77-86. https://doi.org/10.12677/AMC.2023.114010

参考文献

[1] 胡燕, 白继庚, 胡先明, 王思洁, 武建康, 孔丽丽, 卢祖洵. 我国抗生素滥用现状、原因及对策探讨[J]. 中国社会医学杂志, 2013, 30(2): 128-130.
[2] 罗伟华. 浅析我国抗生素滥用的现状及对策研究[J]. 北方医药, 2013, 10(11): 85-86.
[3] 丁志刚, 王静, 高红梅. 抗生素残留检测技术的研究进展[J]. 食品与发酵工业, 2005, 31(6): 112-116.
[4] 王记鲁. 制药污水处理系统中典型抗生素抗性基因的分布特征及归趋研究[D]: [硕士学位论文]. 天津: 南开大学, 2015.
[5] 石浩. 沉积物中20种抗生素残留的分析方法及其应用[D]: [硕士学位论文]. 上海: 华东师范大学, 2014.
[6] 陈佳虹. 喹诺酮类药物广谱免疫分析研究[D]: [硕士学位论文]. 广州: 华南农业大学, 2016.
[7] 杜国安, 孙仲葆, 熊久林, 王高升, 余淑芳, 金萍, 李烈. 高效液相色谱法测定甲诺参洗剂中甲硝唑及诺氟沙星的含量[J]. 中国医院药学杂志, 2005, 25(2): 140-141.
[8] Cao, Y., Zhang, Y., Gu, L.-W., Qin, X.-M., Li, H.-Y., Bian, H.-D. and Huang, F.-P. (2020) A Zinc2+-Dpbt Framework: Luminescence Sensing of Cu2+, Ag+, MnO4- and Cr(VI) (Cr2O72- and CrO42-) Ions. New Journal of Chemistry, 44, 10681-10688. [Google Scholar] [CrossRef] 
[9] Zhou, H.-C., Long, J.R. and Yaghi, O.M. (2012) Introduction to Metal-Organic Frameworks. Chemical Reviews, 112, 673-674. [Google Scholar] [CrossRef] [PubMed]
[10] Shi, Y.-S., Xiao, Q.-Q., Fu, L. and Cui, G.-H. (2020) Three Water-Stable Luminescent Two-Dimensional CdII-Based Coordination Polymers as Sensors for Highly Sensitive and Selective Detection of Cr2O72- and CrO2- Anions. CrystEngComm, 22, 4875-4886. [Google Scholar] [CrossRef] 
[11] Liu, G., Li, Y., Chi, J., Xu, N., Wang, X., Lin, H., Chen, B. and Li, J. (2020) Various Cd(II) Coordination Polymers Induced by Carboxylates: Multi-Functional Detection of Fe3+, Anions, Aspartic Acids and Bovine Serum Albumin. Dalton Transactions, 49, 737-749. [Google Scholar] [CrossRef] 
[12] Samanta, P., Let, S., Manda, W., Dutta, S. and Ghosh, S.K. (2020) Luminescent Metal-Organic Frameworks (LMOFs) as Potential Probes for the Recognition of Cationic Water Pollutants. Inorganic Chemistry Frontiers, 7, 1801-1821. [Google Scholar] [CrossRef] 
[13] Roy, B., Mukherjee, S. and Mukherjee, P.S. (2013) Sr2+ and Cd2+ Coordina-tion Polymers: The Effect of the Different Coordinating Behaviour of a Newly Designed Tricarboxylic Acid. CrystEngComm, 15, 9596-9602. [Google Scholar] [CrossRef] 
[14] Sheldrick, G.M. (1997) SHELXL-97, Program for X-Ray Crystal Structure Re-finement. Göttingen University, Göttingen.
[15] Ren, Y., Yang, X., Wang, Z., Chai, H., Zhang, M., Chen, X. and Wang, J. (2021) Structural Diversity and Fluorescence Properties of Lead (II) Complexes Based on A Flexible Tricarboxylate and Two Large Conjugate N-Donor Ligands. Journal of Solid State Chemistry, 294, Article ID: 121875. [Google Scholar] [CrossRef] 
[16] Zhao, X.-Y., Liang, B., Xiong, K.-C., Shi, Y.-W., Yang, S.-L., Wei, T.-Y., Zhang, H., Zhang, Q.-F. and Ga, Y.-L. (2020) Two Novel Lead-Based Coordination Polymers for Luminescence Sens-ing of Anions, Cations and Small Organic Molecules. Dalton Transactions, 49, 5695-5702. [Google Scholar] [CrossRef] 
[17] Blatov, V.A. (2019) TOPOS, a Multipurpose Crystallochemical Analysis with the Program Package. Samara State University, Samara.
[18] Liu, G.-N., Zhao, R.-Y., Xu, R.-D., Zhang, X., Tang, X.-N., Dan, Q.-J., Wei, Y.-W., Tu, Y.-Y., Bo, Q.-B. and Li, C. (2018) A Novel Tetranuclear Copper(I) Iodide Metal-Organic Cluster [Cu4I4(Ligand)5] with Highly Selective Luminescence Detection of Antibiotic. Crystal Growth & Design, 18, 5441-5448. [Google Scholar] [CrossRef] 
[19] Yan, Y., Zhang, J., Ren, L. and Tang, C. (2016) Metal-Containing and Re-lated Polymers for Biomedical Applications. Chemical Society Reviews, 45, 5232-5263. [Google Scholar] [CrossRef] 
[20] Yao, X.-Q., Xiao, G.-B., Xie, H., Qin, D.-D., Ma, H.-C., Liu, J.-C. and Yan, P.-J. (2019) Two Triphenylamine-Based Luminescent Metal–Organic Frameworks as a Dual-Functional Sensor for the Detec-tion of Nitroaromatic Compounds and Ofloxacin Antibiotic. CrystEngComm, 21, 2559-2570. [Google Scholar] [CrossRef] 
[21] He, H., Zhu, Q.-Q., Sun, F. and Zhu, G. (2018) Two 3D Metal-Organic Frameworks Based on CoII and ZnII Clusters for Knoevenagel Condensation Reaction and Highly Selective Luminescence Sensing. Crystal Growth & Design, 18, 5573-5581. [Google Scholar] [CrossRef] 
[22] Han, M.-L., Wen, G.-X., Dong, W.-W., Zhou, Z.-H., Wu, Y.-P., Zhao, J., Li, D.-S., Ma, L.-F. and Bu, X.-H. (2017) A Heterometallic Sodi-um-Europium-Cluster-Based Metal-Organic Framework as a Versatile and Water-Stable Chemosensor for Antibiotics and Ex-plosives. Journal of Materials Chemistry C, 5, 8469-8474. [Google Scholar] [CrossRef]