|
[1]
|
Khan, M.A., et al. (2020) Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study. Cureus, 12, e9349. [Google Scholar] [CrossRef] [PubMed]
|
|
[2]
|
Madonna, R., et al. (2016) Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: Cell-Based Therapies for Myocardial Repair and Regeneration in Ischemic Heart Disease and Heart Failure. European Heart Journal, 37, 1789-1798. [Google Scholar] [CrossRef] [PubMed]
|
|
[3]
|
Bektik, E. and Fu, J.D. (2019) Ameliorating the Fibrotic Remodeling of the Heart through Direct Cardiac Reprogramming. Cells, 8, Article 679. [Google Scholar] [CrossRef] [PubMed]
|
|
[4]
|
van Berlo, J.H. and Molkentin, J.D. (2014) An Emerging Consensus on Cardiac Regeneration. Nature Medicine, 20, 1386-1393. [Google Scholar] [CrossRef] [PubMed]
|
|
[5]
|
Fu, J.D. and Sri-vastava, D. (2015) Direct Reprogramming of Fibroblasts into Cardiomyocytes for Cardiac Regenerative Medicine. Cir-culation Journal, 79, 245-254. [Google Scholar] [CrossRef]
|
|
[6]
|
Rao, M.S. and Malik, N. (2012) As-sessing iPSC Reprogramming Methods for Their Suitability in Translational Medicine. Journal of Cellular Biochemistry, 113, 3061-3068. [Google Scholar] [CrossRef] [PubMed]
|
|
[7]
|
Fu, Y., et al. (2015) Direct Reprogramming of Mouse Fi-broblasts into Cardiomyocytes with Chemical Cocktails. Cell Research, 25, 1013-1024. [Google Scholar] [CrossRef] [PubMed]
|
|
[8]
|
Lee, C.S., et al. (2017) Adenovirus-Mediated Gene Delivery: Potential Ap-plications for Gene and Cell-Based Therapies in the New Era of Personalized Medicine. Genes & Diseases, 4, 43-63. [Google Scholar] [CrossRef] [PubMed]
|
|
[9]
|
Patel, V., et al. (2016) Direct Cardiac Cellular Reprogramming for Cardiac Regeneration. Current Treatment Options in Cardiovascular Medicine, 18, Article No. 58. [Google Scholar] [CrossRef] [PubMed]
|
|
[10]
|
Ebert, A.D., Liang, P. and Wu, J.C. (2012) Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform. Journal of Cardiovascular Pharmacology, 60, 408-416. [Google Scholar] [CrossRef]
|
|
[11]
|
Chen, T. and Vunjak-Novakovic, G. (2018) In vitro Models of Ischemia-Reperfusion Injury. Regenerative Engineering and Translational Medicine, 4, 142-153. [Google Scholar] [CrossRef] [PubMed]
|
|
[12]
|
Wang, H.F., Yang, Y.C., Liu, J.D. and Qian, L. (2021) Direct Cell Reprogramming: Approaches, Mechanisms and Progress. Nature Reviews Molecular Cell Biology, 22, 410-424. [Google Scholar] [CrossRef] [PubMed]
|
|
[13]
|
Tai, Y.L., Chen, K.C., Hsieh, J.T. and Shen, T.L. (2018) Exo-somes in Cancer Development and Clinical Applications. Cancer Science, 109, 2364-2374. [Google Scholar] [CrossRef] [PubMed]
|
|
[14]
|
Querdel, E., et al. (2021) Human Engineered Heart Tissue Patches Re-muscularize the Injured Heart in a Dose-Depen- dent Manner. Circulation, 143, 1991-2006. [Google Scholar] [CrossRef]
|
|
[15]
|
Martins, A.M., Vunjak-Novakovic, G. and Reis, R.L. (2014) The Current Status of iPS Cells in Cardiac Research and Their Potential for Tissue Engineering and Regen-erative Medicine. Stem Cell Reviews and Reports, 10, 177-190. [Google Scholar] [CrossRef] [PubMed]
|
|
[16]
|
Teshigawara, R., Cho, J., Kamed, M. and Tada, T. (2017) Mecha-nism of Human Somatic Reprogramming to iPS Cell. Laboratory Investigation, 97, 1152-1157. [Google Scholar] [CrossRef] [PubMed]
|
|
[17]
|
Tang, B.L. (2020) Maturing iPSC-Derived Cardiomyocytes. Cells, 9, Article 213. [Google Scholar] [CrossRef] [PubMed]
|
|
[18]
|
Pianezzi, E., et al. (2020) Role of Somatic Cell Sources in the Maturation Degree of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Biochimica et Biophysica Acta (BBA)—Molecular Cell Research, 1867, Article ID: 118538. [Google Scholar] [CrossRef] [PubMed]
|
|
[19]
|
Altomare, C., et al. (2016) Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Cardiac Progenitor Cells: Effects of Selective Ion Channel Blockade. Europace, 18, iv67.
|
|
[20]
|
Tohyama, S., et al. (2013) Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes. Cell Stem Cell, 12, 127-137. [Google Scholar] [CrossRef] [PubMed]
|
|
[21]
|
Ieda, M., et al. (2010) Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors. Cell, 142, 375-386. [Google Scholar] [CrossRef] [PubMed]
|
|
[22]
|
Wang, D., et al. (2014) MicroRNA-124 Controls the Proliferative, Migratory, and Inflammatory Phenotype of Pulmonary Vascular Fibroblasts. Circulation Research, 114, 67-78. [Google Scholar] [CrossRef]
|
|
[23]
|
Qian, L., et al. (2012) In vivo Reprogramming of Murine Cardiac Fibroblasts into Induced Cardiomyocytes. Nature, 485, 593-598. [Google Scholar] [CrossRef] [PubMed]
|
|
[24]
|
Song, K., et al. (2012) Heart Repair by Reprogramming Non-Myocytes with Cardiac Transcription Factors. Nature, 485, 599-604. [Google Scholar] [CrossRef] [PubMed]
|
|
[25]
|
Fu, J.D., et al. (2013) Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-Like State. Stem Cell Reports, 1, 235-247. [Google Scholar] [CrossRef] [PubMed]
|
|
[26]
|
Nam, Y.J., et al. (2013) Reprogramming of Human Fibroblasts toward a Cardiac Fate. Proceedings of the National Academy of Sciences of the United States of America, 110, 5588-5593. [Google Scholar] [CrossRef] [PubMed]
|
|
[27]
|
Wada, R., et al. (2013) Induction of Human Cardiomy-ocyte-Like Cells from Fibroblasts by Defined Factors. Proceedings of the National Academy of Sciences of the United States of America, 110, 12667-12672. [Google Scholar] [CrossRef] [PubMed]
|
|
[28]
|
Bektik, E., Dennis, A., Prasanna, P., Madabhushi, A. and Fu, J.D. (2017) Single Cell qPCR Reveals That Additional HAND2 and MicroRNA-1 Facilitate the Early Reprogramming Pro-gress of Seven-Factor-Induced Human Myocytes. PLOS ONE, 12, e0183000. [Google Scholar] [CrossRef] [PubMed]
|
|
[29]
|
Jorstad, N.L., et al. (2017) Stimulation of Functional Neuronal Regeneration from Müller Glia in Adult Mice. Nature, 548, 103-107. [Google Scholar] [CrossRef] [PubMed]
|
|
[30]
|
Li, H. and Chen, G. (2016) In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells. Neuron, 91, 728-738. [Google Scholar] [CrossRef] [PubMed]
|
|
[31]
|
Chen, Y.Q., Yang, Z.Y., Zhao, Z.A. and Shen, Z.Y. (2017) Direct Reprogramming of Fibroblasts into Cardiomyocytes. Stem Cell Research & Therapy, 8, Article No. 118. [Google Scholar] [CrossRef] [PubMed]
|
|
[32]
|
Wang, L., et al. (2015) Stoichiometry of Gata4, Mef2c, and Tbx5 Influences the Efficiency and Quality of Induced Cardiac Myocyte Reprogramming. Circulation Research, 116, 237-244. [Google Scholar] [CrossRef]
|
|
[33]
|
Li, X.H., et al. (2015) Generation of Functional Human Cardiac Progenitor Cells by High-Efficiency Protein Transduction. Stem Cells Translational Medicine, 4, 1415-1424. [Google Scholar] [CrossRef] [PubMed]
|
|
[34]
|
Pasumarthi, K.B. and Field, L.J. (2002) Cardiomyocyte Cell Cycle Regulation. Circulation Research, 90, 1044-1054. [Google Scholar] [CrossRef]
|
|
[35]
|
Barreto, S., Hamel, L., Schiatti, T., Yang, Y. and George, V. (2019) Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials. Cells, 8, Article 1536. [Google Scholar] [CrossRef] [PubMed]
|
|
[36]
|
Li, P., Kaslan, M., Lee, S.H., Yao, J. and Gao, Z.Q. (2017) Pro-gress in Exosome Isolation Techniques. Theranostics, 7, 789-804. [Google Scholar] [CrossRef] [PubMed]
|
|
[37]
|
Sandmaier, S.E. and Telugu, B.P. (2015) MicroRNA-Mediated Repro-gramming of Somatic Cells into Induced Pluripotent Stem Cells. In: Verma, P. and Sumer, H., Eds., Cell Reprogram-ming, Humana Press, New York, 29-36. [Google Scholar] [CrossRef] [PubMed]
|
|
[38]
|
Elmén, J., et al. (2008) LNA-Mediated MicroRNA Silencing in Non-Human Primates. Nature, 452, 896-899. [Google Scholar] [CrossRef] [PubMed]
|
|
[39]
|
Sridharan, R. and Plath, K. (2011) Small RNAs Loom Large during Re-programming. Cell Stem Cell, 8, 599-601. [Google Scholar] [CrossRef] [PubMed]
|
|
[40]
|
Jayawardena, T.M., et al. (2012) MicroRNA-Mediated in Vitro and in Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes. Circulation Research, 110, 1465-1473. [Google Scholar] [CrossRef]
|
|
[41]
|
Maitra, M., et al. (2009) Interaction of Gata4 and Gata6 with Tbx5 Is Critical for Normal Cardiac Development. Developmental Biology, 326, 368-377. [Google Scholar] [CrossRef] [PubMed]
|
|
[42]
|
Oka, T., et al. (2006) Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte Viability. Circulation Research, 98, 837-845. [Google Scholar] [CrossRef]
|
|
[43]
|
Lin, Q., Schwarz, J., Bucana, C. and Olson, E.N. (1997) Control of Mouse Cardiac Morphogenesis and Myogenesis by Transcription Factor MEF2C. Science, 276, 1404-1407. [Google Scholar] [CrossRef] [PubMed]
|
|
[44]
|
Protze, S., et al. (2012) A New Approach to Tran-scription Factor Screening for Reprogramming of Fibroblasts to Cardiomyocyte-Like Cells. Journal of Molecular and Cellular Cardiology, 53, 323-332. [Google Scholar] [CrossRef] [PubMed]
|
|
[45]
|
Mathison, M., et al. (2017) Cardiac Reprogramming Factor Ga-ta4 Reduces Postinfarct Cardiac Fibrosis through Direct Repression of the Profibrotic Mediator Snail. The Journal of Thoracic and Cardiovascular Surgery, 154, 1601- 1610.E3. [Google Scholar] [CrossRef] [PubMed]
|
|
[46]
|
Addis, R.C., et al. (2013) Optimization of Direct Fibroblast Re-programming to Cardiomyocytes Using Calcium Activity as a Functional Measure of Success. Journal of Molecular and Cellular Cardiology, 60, 97-106. [Google Scholar] [CrossRef] [PubMed]
|
|
[47]
|
Hirai, H., Katoku-Kikyo, N., Karian, P., Firpo, M. and Kikyo, N. (2012) Efficient iPS Cell Production with the MyoD Transactivation Domain in Serum-Free Culture. PLOS ONE, 7, e34149. [Google Scholar] [CrossRef] [PubMed]
|
|
[48]
|
Hirai, H., Katoku-Kikyo, N., Keirstead, S.A. and Kikyo, N. (2013) Accelerated Direct Reprogramming of Fibroblasts into Cardiomyocyte-Like Cells with the MyoD Transactivation Domain. Cardiovascular Research, 100, 105-113. [Google Scholar] [CrossRef] [PubMed]
|
|
[49]
|
Zhou, H., Dickson, M.E., Kim, M.S., Bassel-Duby, R. and Olson, E.N. (2015) Akt1/Protein Kinase B Enhances Transcriptional Reprogramming of Fibroblasts to Functional Cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America, 112, 11864-11869. [Google Scholar] [CrossRef] [PubMed]
|
|
[50]
|
Abad, M., et al. (2017) Notch Inhibition Enhances Cardiac Repro-gramming by Increasing MEF2C Transcriptional Activity. Stem Cell Reports, 8, 548-560. [Google Scholar] [CrossRef] [PubMed]
|
|
[51]
|
Collesi, C., Zentilin, L., Sinagra, G. and Giacca, M. (2008) Notch1 Signaling Stimulates Proliferation of Immature Cardiomyocytes. Journal of Cell Biology, 183, 117-128. [Google Scholar] [CrossRef] [PubMed]
|
|
[52]
|
Liu, Y., et al. (2014) Timely Inhibition of Notch Signaling by DAPT Promotes Cardiac Differentiation of Murine Pluripotent Stem Cells. PLOS ONE, 9, e109588. [Google Scholar] [CrossRef] [PubMed]
|
|
[53]
|
Zhou, Y., et al. (2016) Bmi1 Is a Key Epigenetic Barrier to Di-rect Cardiac Reprogramming. Cell Stem Cell, 18, 382- 395. [Google Scholar] [CrossRef] [PubMed]
|
|
[54]
|
Guo, Y., et al. (2019) Chemical Suppression of Specific C-C Chemokine Signaling Pathways Enhances Cardiac Reprogram-ming. Journal of Biological Chemistry, 294, 9134-9146. [Google Scholar] [CrossRef]
|
|
[55]
|
Singh, V.P., et al. (2021) Hippo Pathway Effector Tead1 Induces Cardiac Fibroblast to Cardiomyocyte Reprogramming. Jour-nal of the American Heart Association, 10, e022659. [Google Scholar] [CrossRef]
|
|
[56]
|
Bock-Marquette, I., Saxena, A., White, M.D., DiMaio, J.M. and Srivastava, D. (2004) Thymosin β4 Activates Integrin-Linked Kinase and Promotes Cardiac Cell Migration, Survival and Cardiac Repair. Nature, 432, 466-472. [Google Scholar] [CrossRef] [PubMed]
|
|
[57]
|
Vincentz, J.W., Toolan, K.P., Zhang, W.J. and Firulli, A.B. (2017) Hand Factor Ablation Causes Defective Left Ventricular Chamber Development and Compromised Adult Cardiac Function. PLOS GENETICS, 13, e1006922. [Google Scholar] [CrossRef] [PubMed]
|
|
[58]
|
VanDusen, N.J., et al. (2014) Hand2 Is an Essential Regulator for Two Notch-Dependent Functions within the Embryonic Endocardium. Cell Reports, 9, 2071-2083. [Google Scholar] [CrossRef] [PubMed]
|
|
[59]
|
Inagawa, K., et al. (2012) Induction of Cardiomyocyte-Like Cells in Infarct Hearts by Gene Transfer of Gata4, Mef2c, and Tbx5. Circulation Research, 111, 1147-1156. [Google Scholar] [CrossRef]
|
|
[60]
|
Mathison, M., et al. (2014) “Triplet” Polycistronic Vec-tors Encoding Gata4, Mef2c, and Tbx5 Enhances Postinfarct Ventricular Functional Improvement Compared with Singlet Vectors. The Journal of Thoracic and Cardiovascular Surgery, 148, 1656-1664.E2. [Google Scholar] [CrossRef] [PubMed]
|
|
[61]
|
Islas, J.F., et al. (2012) Transcription Factors ETS2 and MESP1 Transdifferentiate Human Dermal Fibroblasts into Cardiac Progenitors. Proceedings of the National Academy of Sciences of the United States of America, 109, 13016- 13021. [Google Scholar] [CrossRef] [PubMed]
|
|
[62]
|
Wang, T., et al. (2015) Estrogen-Related Receptor α (ERRα) and ERRγ Are Essential Coordinators of Cardiac Metabolism and Function. Molecular and Cellular Biology, 35, 1281-1298. [Google Scholar] [CrossRef]
|
|
[63]
|
Zhang, W., et al. (2014) Novel Missense Variants of ZFPM2/FOG2 Identified in Conotruncal Heart Defect Patients Do Not Impair Inter-action with GATA4. PLOS ONE, 9, e102379. [Google Scholar] [CrossRef] [PubMed]
|
|
[64]
|
Muraoka, N., et al. (2014) MiR-133 Promotes Cardiac Reprogramming by Directly Repressing Snai1 and Silencing Fibroblast Signa-tures. The EMBO Journal, 33, 1565-1581. [Google Scholar] [CrossRef] [PubMed]
|
|
[65]
|
Christoforou, N., et al. (2017) Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts towards the Cardiac Cell Lineage. Scientific Reports, 7, Article No. 40285. [Google Scholar] [CrossRef] [PubMed]
|
|
[66]
|
Gassmann, M., et al. (1995) Aberrant Neural and Cardiac Development in Mice Lacking the ErbB4 Neuregulin Receptor. Nature, 378, 390-394. [Google Scholar] [CrossRef] [PubMed]
|
|
[67]
|
Pomeroy, J.E., Helfer, A. and Bursac, N. (2020) Biomaterializing the Prom-ise of Cardiac Tissue Engineering. Biotechnology Advances, 42, Article ID: 107353. [Google Scholar] [CrossRef] [PubMed]
|
|
[68]
|
Sadahiro, T., et al. (2018) Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification. Cell Stem Cell, 23, 382-395.E5. [Google Scholar] [CrossRef] [PubMed]
|
|
[69]
|
Christoforou, N., et al. (2013) Transcription Factors MYOCD, SRF, Mesp1 and SMARCD3 Enhance the Cardio-Indu- cing Effect of GATA4, TBX5, and MEF2C during Direct Cellular Reprogramming. PLOS ONE, 8, e63577. [Google Scholar] [CrossRef] [PubMed]
|
|
[70]
|
Zhao, H., et al. (2021) Sall4 and Myocd Empower Direct Car-diac Reprogramming from Adult Cardiac Fibroblasts after Injury. Frontiers in Cell and Developmental Biology, 9, Article 608367. [Google Scholar] [CrossRef] [PubMed]
|
|
[71]
|
Sia, J., Yu, P.Z., Srivastava, D. and Li, S. (2016) Effect of Biophysical Cues on Reprogramming to Cardiomyocytes. Biomaterials, 103, 1-11. [Google Scholar] [CrossRef] [PubMed]
|
|
[72]
|
Kurotsu, S., et al. (2020) Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures. Stem Cell Reports, 15, 612-628. [Google Scholar] [CrossRef] [PubMed]
|
|
[73]
|
Li, Y., et al. (2016) Tissue-Engineered 3-Dimensional (3D) Mi-croenvironment Enhances the Direct Reprogramming of Fibroblasts into Cardiomyocytes by MicroRNAs. Scientific Re-ports, 6, Article No. 38815. [Google Scholar] [CrossRef] [PubMed]
|
|
[74]
|
Bunney, P.E., Zink, A.N., Holm, A.A., Billington, C.J. and Kotz, C.M. (2017) Orexin Activation Counteracts Decreases in Nonexercise Activity Thermogenesis (NEAT) Caused by High-Fat Diet. Physiology & Behavior, 176, 139-148. [Google Scholar] [CrossRef] [PubMed]
|
|
[75]
|
Sauls, K., et al. (2018) Initiating Events in Direct Cardiomyo-cyte Reprogramming. Cell Reports, 22, 1913-1922. [Google Scholar] [CrossRef] [PubMed]
|
|
[76]
|
Smith, A.W., et al. (2013) Direct Reprogramming of Mouse Fi-broblasts to Cardiomyocyte-Like Cells Using Yamanaka Factors on Engineered Poly (Ethylene Glycol) (PEG) Hydro-gels. Biomaterials, 34, 6559-6571. [Google Scholar] [CrossRef] [PubMed]
|
|
[77]
|
Liu, Z., et al. (2016) Re-Patterning of H3K27me3, H3K4me3 and DNA Methylation during Fibroblast Conversion into Induced Cardiomyocytes. Stem Cell Research, 16, 507-518. [Google Scholar] [CrossRef] [PubMed]
|
|
[78]
|
Liu, Z., et al. (2017) Single-Cell Transcriptomics Recon-structs Fate Conversion from Fibroblast to Cardiomyocyte. Nature, 551, 100-104. [Google Scholar] [CrossRef] [PubMed]
|
|
[79]
|
Plotkin, J.B. (2010) Transcriptional Regulation Is Only Half the Story. Molecular Systems Biology, 6, 406. [Google Scholar] [CrossRef] [PubMed]
|
|
[80]
|
Liu, Y., et al. (2018) CRISPR Activation Screens Systematically Identify Factors That Drive Neuronal Fate and Reprogramming. Cell Stem Cell, 23, 758-771.E8. [Google Scholar] [CrossRef] [PubMed]
|
|
[81]
|
Weltner, J., et al. (2018) Human Pluripotent Reprogramming with CRISPR Activators. Nature Communications, 9, Article No. 2643. [Google Scholar] [CrossRef] [PubMed]
|
|
[82]
|
Farbehi, N., et al. (2019) Single-Cell Expression Profiling Re-veals Dynamic Flux of Cardiac Stromal, Vascular and Immune Cells in Health and Injury. eLife, 8, e43882. [Google Scholar] [CrossRef]
|
|
[83]
|
Skelly, D.A., et al. (2018) Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart. Cell Reports, 22, 600-610. [Google Scholar] [CrossRef] [PubMed]
|