未足月胎膜早破的研究进展

Research Progress in Preterm Premature Rupture of Membranes

摘要: 未足月胎膜早破(preterm premature rupture of membranes, PPROM)是导致妊娠期早产的主要原因之一。可增加产妇及新生儿并发症的发生率。其病因尚未明确，目前研究认为是多种因素共同作用的结果，且无明确的手段能对其发生进行早期预测。其最主要的病因是感染。目前临床上主张依据孕周及母体和胎儿的生命体征进行个体化治疗，个体化的针对性治疗虽有助于减少母儿并发症的发生率。但仍存在早期诊断缺乏特异性指标，诊疗时间滞后、被动等问题。故通过对病因进行分析达到对PPROM进行早期预测，有利于减少产妇及新生儿的并发症。通过对病因进行低成本筛查和干预，有助于PPROM的早期防控。

Abstract: Preterm premature rupture of membranes is one of the main causes of premature birth during pregnancy. It can increase the incidence of maternal and neonatal complications. The etiology is not clear, At present, many factors are considered to be the result of joint action, and there is no clear means to predict its occurrence in early stage. The main cause is infection. At present, clinical treatment is individualized according to the gestational age and vital signs of mother and fetus. Although individualized acupuncture treatment helps reduce the incidence of maternal and fetal complications. However, there are still some problems in early diagnosis, such as lack of specific in-dicators, delay in diagnosis and treatment, passive and so on. Therefore, it is helpful to reduce the complications of parturient and newborn by analyzing the etiology to achieve early prediction of PPROM. It is helpful to prevent and control PPROM in early stage through low-cost screening and intervention.