呼吸道合胞病毒感染在唐氏综合征儿童中的研究进展
Research Progress of Respiratory Syncytial Virus Infection in Children with Down Syndrome
DOI: 10.12677/ACM.2023.13102184, PDF,    科研立项经费支持
作者: 王 蓉, 刘恩梅, 邓 昱*：重庆医科大学附属儿童医院呼吸科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿科学重庆市重点实验室，重庆
关键词: 呼吸道合胞病毒；呼吸道感染；唐氏综合征；Respiratory Syncytial Virus； Respiratory Tract Infection； Down Syndrome
摘要: 呼吸道合胞病毒是引起5岁以下儿童急性下呼吸道感染最常见的病原体之一，几乎所有儿童在两岁前都会经历一次RSV感染。特殊健康状态儿童是严重RSV感染的危险因素，除先天性心脏病、支气管肺发育不良外，唐氏综合征儿童中的RSV感染受到了越来越多的关注，DS是RSV感染患儿住院和死亡的独立危险因素之一，故了解DS患儿中RSV感染的疾病负担、临床特征、发病机制、预防至关重要，本文将从以上四个方面进行综述。
Abstract: Respiratory syncytial virus (RSV) is one of the most common pathogens causing acute lower respir-atory infection (ALRI) in children under 5 years of age, and almost all children will experience an RSV infection before the age of 2 years. Children with special health status are risk factors for severe RSV infection. In addition to congenital heart disease (CHD) and bronchopulmonary dysplasia (BPD), RSV infection in children with Down syndrome (DS) has received increasing attention. DS is one of the independent risk factors for hospitalization and death in children with RSV infection. Therefore, it is very important to understand the disease burden, clinical features, pathogenesis and preven-tion of RSV infection in children with DS. This paper will review it from the above four aspects.
文章引用：王蓉, 刘恩梅, 邓昱. 呼吸道合胞病毒感染在唐氏综合征儿童中的研究进展[J]. 临床医学进展, 2023, 13(10): 15614-15620. https://doi.org/10.12677/ACM.2023.13102184

参考文献

[1] Hu, M., Bogoyevitch, M.A. and Jans, D.A. (2020) Impact of Respiratory Syncytial Virus Infection on Host Functions: Implications for Antiviral Strategies. Physiological Reviews, 100, 1527-1594. [Google Scholar] [CrossRef] [PubMed]
[2] Li, Y., Wang, X., Blau, D.M., et al. (2022) Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Chil-dren Younger than 5 Years in 2019: A Systematic Analysis. The Lancet, 399, 2047-2064. [Google Scholar] [CrossRef] 
[3] Luna, M.S., Manzoni, P., Paes, B., et al. (2020) Expert Consensus on Palivizumab Use for Respiratory Syncytial Virus in Developed Countries. Paediatric Respiratory Reviews, 33, 35-44. [Google Scholar] [CrossRef] [PubMed]
[4] Thwaites, R., Buchan, S., Fullarton, J., et al. (2020) Clinical Burden of Severe Respiratory Syncytial Virus Infection during the First 2 Years of Life in Children Born be-tween 2000 and 2011 in Scotland. European Journal of Pediatrics, 179, 791-799. [Google Scholar] [CrossRef] [PubMed]
[5] Cai, W., Buda, S., Schuler, E., et al. (2020) Risk Factors for Hospitalized Respiratory Syncytial Virus Disease and Its Severe Outcomes. Influenza and Other Respiratory Viruses, 14, 658-670. [Google Scholar] [CrossRef] [PubMed]
[6] Shi, T., Vennard, S., Mahdy, S., Nair, H. and RESCEU Investi-gators (2022) Risk Factors for Poor Outcome or Death in Young Children with Respiratory Syncytial Virus-Associated Acute Lower Respiratory Tract Infection: A Systematic Review and Meta-Analysis. The Journal of Infectious Diseases, 226, S10-S16. [Google Scholar] [CrossRef] [PubMed]
[7] Chaw, P.S., Wong, S.W.L., Cunningham, S., et al. (2020) Acute Lower Respiratory Infections Associated with Respiratory Syncytial Virus in Children with Underlying Congenital Heart Dis-ease: Systematic Review and Meta-Analysis. The Journal of Infectious Diseases, 222, S613-S619.
[8] Chaw, P.S., Hua, L., Cunningham, S., et al. (2020) Respiratory Syncytial Virus-Associated Acute Lower Respiratory Infections in Children with Bronchopulmonary Dysplasia: Systematic Review and Meta-Analysis. The Journal of Infectious Diseases, 222, S620-S627
[9] Manzoni, P., Figueras-Aloy, J., Simões, E.A.F., et al. (2017) Defining the Incidence and Associ-ated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection among Children with Chronic Diseases. Infectious Diseases and Therapy, 6, 383-411. [Google Scholar] [CrossRef] [PubMed]
[10] Beckhaus, A.A. and Castro-Rodriguez, J.A. (2018) Down Syndrome and the Risk of Severe RSV Infection: A Meta-Analysis. Pediatrics, 142, e20180225. [Google Scholar] [CrossRef] [PubMed]
[11] Shmueli, E., Goldberg, O., Mei-Zahav, M., et al. (2021) Risk Factors for Respiratory Syncytial Virus Bronchiolitis Hospitalizations in Children with Chronic Diseases. Pediatric Pulmonology, 56, 2204-2211. [Google Scholar] [CrossRef] [PubMed]
[12] Mitra, S., El Azrak, M., McCord, H. and Paes, B.A. (2018) Hospitaliza-tion for Respiratory Syncytial Virus in Children with Down Syndrome Less than 2 Years of Age: A Systematic Review and Meta-Analysis. The Journal of Pediatrics, 203, 92-100.E3. [Google Scholar] [CrossRef] [PubMed]
[13] Okamoto, K., Morio, T., Nakamura, Y., et al. (2021) Hospitalisa-tions Due to Respiratory Syncytial Virus Infection in Children with Down Syndrome before and after Palivizumab Rec-ommendation in Japan. Acta Paediatrica, 110, 1299-1306. [Google Scholar] [CrossRef] [PubMed]
[14] Santoro, S.L., Chicoine, B., Jasien, J.M., et al. (2021) Pneumonia and Respiratory Infections in Down Syndrome: A Scoping Review of the Literature. American Journal of Medical Genetics Part A, 185, 286-299. [Google Scholar] [CrossRef] [PubMed]
[15] Ramphul, K., Mejias, S.G. and Joynauth, J. (2019) Children Less than 2 with Down Syndrome and Suffering from Respiratory Syncytial Virus Have a Longer and More Costly Hospitalization. The Journal of Pediatrics, 206, 302. [Google Scholar] [CrossRef] [PubMed]
[16] Illouz, T., Biragyn, A., Iulita, M.F., et al. (2021) Immune Dysreg-ulation and the Increased Risk of Complications and Mortality following Respiratory Tract Infections in Adults with Down Syndrome. Frontiers in Immunology, 12, Article 621440. [Google Scholar] [CrossRef] [PubMed]
[17] Zhang, X., Chen, L., Wang, X., et al. (2020) Changes in Maternal Age and Prevalence of Congenital Anomalies during the Enactment of China’s Universal Two-Child Policy (2013-2017) in Zhejiang Province, China: An Observational Study. PLOS MEDICINE, 17, e1003047. [Google Scholar] [CrossRef] [PubMed]
[18] Jama-Alol, K.A., Moore, H.C., Jacoby, P., Bower, C. and Lehmann, D. (2014) Morbidity Due to Acute Lower Respiratory Infection in Children with Birth Defects: A Total Popu-lation-Based Linked Data Study. BMC Pediatrics, 14, Article No. 80. [Google Scholar] [CrossRef] [PubMed]
[19] Chan, M., Park, J.J., Shi, T., et al. (2017) The Burden of Respirato-ry Syncytial Virus (RSV) Associated Acute Lower Respiratory Infections in Children with Down Syndrome: A System-atic Review and Meta-Analysis. Journal of Global Health, 7, Article ID: 020413. [Google Scholar] [CrossRef] [PubMed]
[20] Yi, H., Lanctôt, K.L., Bont, L., et al. (2014) Respiratory Syncytial Vi-rus Prophylaxis in Down Syndrome: A Prospective Cohort Study. Pediatrics, 133, 1031-1037. [Google Scholar] [CrossRef] [PubMed]
[21] Stagliano, D.R., Nylund, C.M., Eide, M.B. and Eberly, M.D. (2015) Children with Down Syndrome Are High-Risk for Severe Respiratory Syncytial Virus Disease. The Journal of Pediat-rics, 166, 703-709.e2. [Google Scholar] [CrossRef] [PubMed]
[22] Blake, J.M., Estrada Gomez, D., Skotko, B.G., Torres, A. and Santoro, S.L. (2021) Pneumonia and Respiratory Infection in Down Syndrome: A 10-Year Cohort Analysis of Inpatient and Outpatient Encounters across the Lifespan. American Journal of Medical Genetics Part A, 185, 2878-2887. [Google Scholar] [CrossRef] [PubMed]
[23] Stanley, M.A., Shepherd, N., Duvall, N., et al. (2019) Clinical Identifi-cation of Feeding and Swallowing Disorders in 0-6 Month Old Infants with Down Syndrome. American Journal of Medical Genetics Part A, 179, 177-182. [Google Scholar] [CrossRef] [PubMed]
[24] Eijsvoogel, N.B., Verstegen, R.H.J., van Well, G.T.J., et al. (2022) In-creased Rate of Respiratory Symptoms in Children with Down Syndrome: A 2-Year Web-Based Parent-Reported Pro-spective Study. European Journal of Pediatrics, 181, 4079-4089. [Google Scholar] [CrossRef] [PubMed]
[25] Zachariah, P., Ruttenber, M. and Simões, E.A.F. (2012) Down Syndrome and Hospitalizations Due to Respiratory Syncytial Virus: A Population-Based Study. The Journal of Pediat-rics, 160, 827-831.e1. [Google Scholar] [CrossRef] [PubMed]
[26] Löwensteyn, Y.N., Phijffer, E.W.E.M., Simons, J.V.L., et al. (2020) Respiratory Syncytial Virus-Related Death in Children with Down Syndrome: The RSV GOLD Study. The Pedi-atric Infectious Disease Journal, 39, 665-670. [Google Scholar] [CrossRef] 
[27] Antonarakis, S.E., Skotko, B.G., Rafii, M.S., et al. (2020) Down Syndrome. Nature Reviews Disease Primer. Nature Reviews Disease Primers, 6, Article No. 9. [Google Scholar] [CrossRef] [PubMed]
[28] Lagan, N., Huggard, D., Mc Grane, F., et al. (2020) Multiorgan Involvement and Management in Children with Down Syndrome. Acta Paediatrica, 109, 1096-1111. [Google Scholar] [CrossRef] [PubMed]
[29] Gandy, K.C., Castillo, H.A., Ouellette, L., et al. (2020) The Relationship between Chronic Health Conditions and Cognitive Deficits in Children, Adolescents, and Young Adults with Down Syndrome: A Systematic Review. PLOS ONE, 15, e0239040. [Google Scholar] [CrossRef] [PubMed]
[30] Kats, D.J., Roche, K.J. and Skotko, B.G. (2020) Epileptic Spasms in Individuals with Down Syndrome: A Review of the Current Literature. Epilepsia Open, 5, 344-353. [Google Scholar] [CrossRef] [PubMed]
[31] Santoro, J.D., Pagarkar, D., Chu, D.T., et al. (2021) Neurologic Complica-tions of Down Syndrome: A Systematic Review. Journal of Neurology, 268, 4495-4509. [Google Scholar] [CrossRef] [PubMed]
[32] Paes, B., Kim, D., Saleem, M., et al. (2019) Respiratory Syn-cytial Virus Prophylaxis in Infants with Congenital Airway Anomalies Compared to Standard Indications and Complex Medical Disorders. European Journal of Pediatrics, 178, 377-385. [Google Scholar] [CrossRef] [PubMed]
[33] Gupte, A., Al-Antary, E.T., Edwards, H., et al. (2022) The Par-adox of Myeloid Leukemia Associated with Down Syndrome. Biochemical Pharmacology, 201, Article ID: 115046. [Google Scholar] [CrossRef] [PubMed]
[34] Kimura, D., McNamara, I.F., Wang, J., et al. (2019) Pulmonary Hypertension during Respiratory Syncytial Virus Bronchiolitis: A Risk Factor for Severity of Illness. Cardiology in the Young, 29, 615-619. [Google Scholar] [CrossRef] 
[35] De Lausnay, M., Verhulst, S., Boel, L., et al. (2020) The Preva-lence of Lower Airway Anomalies in Children with Down Syndrome Compared to Controls. Pediatric Pulmonology, 55, 1259-1263. [Google Scholar] [CrossRef] [PubMed]
[36] Alsubie, H.S. and Rosen, D. (2018) The Evaluation and Management of Respiratory Disease in Children with Down Syndrome (DS). Paediatric Respiratory Reviews, 26, 49-54. [Google Scholar] [CrossRef] [PubMed]
[37] Fockens, M.M., Hölscher, M., Limpens, J. and Dikkers, F.G. (2021) Tracheal Anomalies Associated with Down Syndrome: A Systematic Review. Pediatric Pulmonology, 56, 814-822. [Google Scholar] [CrossRef] [PubMed]
[38] Wang, T., Xu, Q., Dai, G., et al. (2021) Clinical Characteristics of Children with Airway Malacia Complicated by Pneumonia. BMC Infectious Diseases, 21, Article No. 902. [Google Scholar] [CrossRef] [PubMed]
[39] Danopoulos, S., Deutsch, G.H., Dumortier, C., Mariani, T.J. and Al Alam, D. (2021) Lung Disease Manifestations in Down Syndrome. American Journal of Physiology-Lung Cellular and Molecular Physiology, 321, L892-L899. [Google Scholar] [CrossRef] [PubMed]
[40] Huggard, D., McGrane, F., Lagan, N., et al. (2018) Altered En-dotoxin Responsiveness in Healthy Children with Down Syndrome. BMC Immunology, 19, Article No. 31. [Google Scholar] [CrossRef] [PubMed]
[41] Bloemers, B.L.P., van Bleek, G.M., Kimpen, J.L.L. and Bont, L. (2010) Distinct Abnormalities in the Innate Immune System of Children with Down Syndrome. The Journal of Pediat-rics, 156, 809.e1-809.e5. [Google Scholar] [CrossRef] [PubMed]
[42] Huggard, D., Koay, W.J., Kelly, L., et al. (2019) Altered Toll-Like Receptor Signalling in Children with Down Syndrome. Mediators of Inflammation, 2019, Article ID: 4068734. [Google Scholar] [CrossRef] [PubMed]
[43] Huggard, D., Doherty, D.G. and Molloy, E.J. (2020) Immune Dysreg-ulation in Children with Down Syndrome. Frontiers in Pediatrics, 8, Article 73. [Google Scholar] [CrossRef] [PubMed]
[44] Seckin, A.N., Ozdemir, H., Ceylan, A. and Artac, H. (2018) Age-Related Alterations of the CD19 Complex and Memory B Cells in Children with Down Syndrome. Clinical and Experimental Medicine, 18, 125-131. [Google Scholar] [CrossRef] [PubMed]

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