脓毒症急性肾损伤生物标记物进展
Progression of Biomarkers of Acute Kidney Injury in Sepsis
DOI: 10.12677/ACM.2023.13102185, PDF,   
作者: 郭思帅:新疆医科大学研究生院,新疆 乌鲁木齐;郭峻氚*:新疆维吾尔自治区人民医院重症医学科,新疆 乌鲁木齐
关键词: 脓毒症脓毒症急性肾损伤生物标志物
摘要: 脓毒症是一种复杂的临床综合征,其特征是对感染性损伤的全身炎症反应。这一过程往往导致广泛的组织损伤和多器官功能障碍。特别是急性肾损伤(acute kidney injury, AKI)的发生是最常见的并发症之一,它增加了治疗的复杂性和费用,是死亡的一个独立危险因素。脓毒症引起的AKI的高死亡率令人无法接受,部分原因是对其诊断延误。这篇综述的目的是关注脓毒症引起的AKI的相关的潜在诊断和预后标志物。
Abstract: Sepsis is a complex clinical syndrome characterized by a systemic inflammatory response to infec-tious injury. This process often leads to extensive tissue damage and multi-organ dysfunction. In particular, the occurrence of acute kidney injury (AKI) is one of the most common complications, which increases the complexity and cost of treatment and is an independent risk factor for death. The high mortality rate of AKI due to sepsis is unacceptable, in part due to delays in its diagnosis. The aim of this review was to focus on potential diagnostic and prognostic markers related to AKI due to sepsis.
文章引用:郭思帅, 郭峻氚. 脓毒症急性肾损伤生物标记物进展[J]. 临床医学进展, 2023, 13(10): 15621-15626. https://doi.org/10.12677/ACM.2023.13102185

参考文献

[1] Liu, J., Xie, H., Ye, Z., et al. (2020) Rates, Predictors, and Mortality of Sepsis-Associated Acute Kidney Injury: A Sys-tematic Review and Meta-Analysis. BMC Nephrology, 21, Article No. 318. [Google Scholar] [CrossRef] [PubMed]
[2] Balkrishna, A., Sinha, S., Kumar, A., et al. (2023) Sep-sis-Mediated Renal Dysfunction: Pathophysiology, Biomarkers and Role of Phytoconstituents in Its Management. Bio-medicine & Pharmacotherapy, 165, Article ID: 115183. [Google Scholar] [CrossRef] [PubMed]
[3] Verma, S. and Kellum, J.A. (2021) Defining Acute Kidney In-jury. Critical Care Clinics, 37, 251-266. [Google Scholar] [CrossRef] [PubMed]
[4] Zhang, Y., Zhang, B., Wang, D., et al. (2020) Evaluation of Novel Biomarkers for Early Diagnosis of Acute Kidney Injury in Asphyxiated Full-Term Newborns: A Case-Control Study. Medical Principles and Practice, 29, 285-291. [Google Scholar] [CrossRef] [PubMed]
[5] 郭颖, 沈业周, 张俭. 尿α1-微球蛋白及尿n-乙酰-β-d-氨基葡萄糖苷酶对脓毒症急性肾损伤的早期预测价值[J]. 健康研究, 2022, 42(4): 455-460. [Google Scholar] [CrossRef
[6] Umbro, I., Gentile, G., Tinti, F., et al. (2016) Re-cent Advances in Pathophysiology and Biomarkers of Sepsis-Induced Acute Kidney Injury. Journal of Infection, 72, 131-142. [Google Scholar] [CrossRef] [PubMed]
[7] de la Varga-Martínez, O., Martín-Fernández, M., Here-dia-Rodríguez, M., et al. (2022) Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery. Journal of Clinical Medicine, 11, Article No. 7274. [Google Scholar] [CrossRef] [PubMed]
[8] Chun, K., Chung, W., Kim, A.J., et al. (2019) Association between Acute Kidney Injury and Serum Procalcitonin Levels and Their Diagnostic Usefulness in Critically Ill Patients. Scientific Reports, 9, Article No. 4777. [Google Scholar] [CrossRef] [PubMed]
[9] Gong, C., Jiang, Y., Tang, Y., et al. (2022) Elevated Serum Lac-tic Acid Level Is an Independent Risk Factor for the Incidence and Mortality of Sepsis-Associated Acute Kidney Injury. Chinese Critical Care Medicine, 34, 714-720.
[10] Jia, L., Cui, S., Yang, J., et al. (2020) Red Blood Cell Distribution Width Predicts Long-Term Mortality in Critically Ill Patients with Acute Kidney Injury: A Retrospective Database Study. Scientific Reports, 10, Article No. 4563. [Google Scholar] [CrossRef] [PubMed]
[11] Ramires, M., Leite, M., Lo, D., et al. (2022) Relation between Red Blood Cell Distribution width and Acute Kidney Injury in Patients with Sepsis. Einstein (São Paulo), 20, eAO6828. [Google Scholar] [CrossRef
[12] 高灵, 张晓光, 李俊, 等. 红细胞分布宽度变化对脓毒症相关急性肾损伤发生的预测价值[J]. 福建医科大学学报, 2022, 56(2): 136-142.
[13] Skrypnyk, N.I., Gist, K.M., Okamura, K., et al. (2020) Il-6-Mediated Hepatocyte Production Is the Primary Source of Plasma and Urine Neu-trophil Gelatinase-Associated Lipocalin during Acute Kidney Injury. Kidney International, 97, 966-979. [Google Scholar] [CrossRef] [PubMed]
[14] Li, H., Xu, Q., Wang, Y., et al. (2020) Serum Neutrophil Gelati-nase-Associated Lipocalin (NGAL) as a Biomarker for Predicting High Dose Methotrexate Associated Acute Kidney In-jury in Children with Acute Lymphoblastic Leukemia. Cancer Chemotherapy and Pharmacology, 85, 95-103. [Google Scholar] [CrossRef] [PubMed]
[15] Khawaja, S., Jafri, L., Siddiqui, I., et al. (2019) The Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a Marker of Acute Kidney Injury (AKI) in Critically Ill Patients. Biomarker Research, 7, Article No. 4. [Google Scholar] [CrossRef] [PubMed]
[16] Park, H.S., Kim, J.W., Lee, K.R., et al. (2019) Urinary Neutrophil Gelatinase-Associated Lipocalin as a Biomarker of Acute Kidney Injury in Sepsis Patients in the Emergency Department. Clinica Chimica Acta, 495, 552-555. [Google Scholar] [CrossRef] [PubMed]
[17] Jedynak, M., Siemiatkowski, A., Milewski, R., et al. (2019) Diag-nostic Effectiveness of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis, Severe Sepsis and Septic Shock. Archives of Medical Science, 15, 713-721. [Google Scholar] [CrossRef] [PubMed]
[18] Pan, P., Liu, X., Wu, L., et al. (2021) Trem-1 Promoted Apoptosis and Inhibited Autophagy in lps-Treated hk-2 Cells through the nf-κb Pathway. International Journal of Medical Sciences, 18, 8-17. [Google Scholar] [CrossRef] [PubMed]
[19] Yuan, Z.K., Fang, F., Liu, C.J., et al. (2018) Value of Urine Soluble Triggering Receptor Expressed on Myeloid Cells-1 in the Early Diagnosis of Sepsis Associated Acute Kidney Injury. Chinese Journal of Pediatrics, 56, 342-346.
[20] Peerapornratana, S., Manrique-Caballero, C.L., Gómez, H., et al. (2019) Acute Kidney Injury from Sepsis: Current Concepts, Epidemiology, Pathophysiology, Prevention and Treat-ment. Kidney International, 96, 1083-1099. [Google Scholar] [CrossRef] [PubMed]
[21] Barbosa, J., Silva Júnior, G., Meneses, G.C., et al. (2022) Use of Non-Conventional Biomarkers in the Early Diagnosis of Acute Kidney Injury in Preterm Newborns with Sepsis. Jornal Brasileiro de Nefrologia, 44, 97-108. [Google Scholar] [CrossRef] [PubMed]
[22] Manrique-Caballero, C.L., Del Rio-Pertuz, G. and Gomez, H. (2021) Sepsis-Associated Acute Kidney Injury. Critical Care Clinics, 37, 279-301. [Google Scholar] [CrossRef] [PubMed]
[23] Sun, T., Qu, S., Huang, T., et al. (2021) Rapid and Sensitive Detec-tion of l-fabp for Prediction and Diagnosis of Acute Kidney Injury in Critically Ill Patients by Chemiluminescent Immu-noassay. Journal of Clinical Laboratory Analysis, 35, e24051. [Google Scholar] [CrossRef] [PubMed]
[24] Oh, D.J. (2020) A Long Journey for Acute Kidney Injury Biomarkers. Renal Failure, 42, 154-165. [Google Scholar] [CrossRef
[25] Miklaszewska, M., Korohoda, P., Kwinta, P., et al. (2013) Early Markers of Acute Kidney Injury in Newborns. Przeglad Lekarski, 70, 19-24.
[26] Varalakshmi, B., Kiranmyai, V.S., Aparna, B., et al. (2020) Plasma Osteopontin Levels in Patients with Acute Kidney Injury Requiring Dialysis: A Study in a Tertiary Care Institute in South India. International Urology and Nephrology, 52, 917-921. [Google Scholar] [CrossRef] [PubMed]
[27] Xie, Y., Tian, R., Jin, W., et al. (2020) Antithrombin III Expres-sion Predicts Acute Kidney Injury in Elderly Patients with Sepsis. Experimental and Therapeutic Medicine, 19, 1024-1032. [Google Scholar] [CrossRef] [PubMed]
[28] Xie, Y., Zhang, Y., Tian, R., et al. (2021) A Prediction Model of Sepsis-Associated Acute Kidney Injury Based on Antithrombin III. Clinical and Experimental Medicine, 21, 89-100. [Google Scholar] [CrossRef] [PubMed]