早产儿肠道菌群失调与相关疾病的研究进展
Research Progress on Intestinal Flora Dysbiosis and Related Diseases in Premature Infants
DOI: 10.12677/ACM.2023.13102188, PDF,   
作者: 邱雁青, 梁玉美:右江民族医学院附属医院,广西 百色
关键词: 早产儿肠道菌群失调疾病Premature Infants Dysbiosis of Intestinal Flora Disease
摘要: 随着围产医学和新生儿重症监护室(Neonatal intensive care unit, NICU)技术迅速发展,早产儿存活率明显提高,早产带来的各种不良结局是目前迫切需要解决的问题。近年来,肠道菌群失调对早产儿不良结局的研究越来越多。早产儿因肠道发育尚未完善,肠道微生物定植落后,不成熟的免疫系统抵御有害细菌和耐受共生细菌的能力有限,易发生肠道菌群失调,早产儿早期肠道菌群失调可影响各系统疾病的发生,本文主要阐述目前早产儿肠道菌群失调与相关疾病的研究进展。
Abstract: With the rapid development of perinatal medicine and neonatal intensive care unit (NICU) tech-nology, the survival rate of premature infants has been significantly improved. Various adverse outcomes caused by premature birth are currently urgent problems to be solved. In recent years, there have been more and more studies on the adverse outcomes of premature infants due to intes-tinal flora dysbiosis. Premature infants are prone to intestinal dysbiosis due to incomplete intesti-nal development, backward intestinal microbial colonization, and the immature immune system’s limited ability to resist harmful bacteria and tolerate commensal bacteria. Early intestinal dysbiosis in premature infants can affect the occurrence of various system diseases. This article mainly ex-pounds on the current research progress of intestinal dysbiosis and related diseases in premature infants.
文章引用:邱雁青, 梁玉美. 早产儿肠道菌群失调与相关疾病的研究进展[J]. 临床医学进展, 2023, 13(10): 15645-15650. https://doi.org/10.12677/ACM.2023.13102188

参考文献

[1] World Health Organization (2012) March of Dimes; The Partnership for Maternal, Newborn & Child Health; Save the Children. Born Too Soon: The Global Action Report on Preterm Birth. Geneva.
[2] 宋东力, 王来栓. 肠道-微生物群-脑轴在新生儿医学研究中的意义和进展[J]. 中华围产医学杂志, 2018, 21(7): 435-441. [Google Scholar] [CrossRef
[3] 孙瑾, 于盼盼, 宋施仪, 等. 早产儿肠道菌群与大脑发育的关系[J]. 中华实用儿科临床杂志, 2022, 37(17): 1358-1360.
[4] Tang, J., Xu, L.Q., Zeng, Y.W. and Gong, F. (2021) Effect of Gut Microbiota on LPS-Induced Acute Lung Injury by Regulating the TLR4/NF-κB Signaling Pathway. International Immunopharmacology, 91, Article ID: 107272. [Google Scholar] [CrossRef] [PubMed]
[5] 王丹虹, 逯军. 肠肺轴对早产儿支气管肺发育不良的影响机制研究进展[J]. 国际儿科学杂志, 2022, 49(9): 620-624.
[6] 陆斯良, 黄清梅, 韦冰梅, 等. 不同分娩方式对晚期早产儿肠道菌群的影响[J]. 中国微生态学杂志, 2019, 31(6): 624-627.
[7] 李喻, 陈婷. 不同喂养方式对早产儿肠道微生态发育的影响[J]. 中国优生与遗传杂志, 2023, 31(5): 997-1001.
[8] 袁方, 胡润芳, 吴良霞, 等. 喂养方式对早产儿在新生儿期肠道菌群分布特征的影响[J]. 教育生物学杂志, 2023, 11(3): 200-206.
[9] 周瑞, 张雪芬, 张宁, 等. 抗生素对早产儿肠道菌群影响的研究[J]. 医学信息, 2023, 36(3): 177-180.
[10] 杨珊珊, 牛春燕, 朱玉瑶. 持续鼻饲输注法喂养对极低出生体重早产儿体格发育及肠道菌群的影响[J]. 全科护理, 2022, 20(30): 4251-4253.
[11] 曾超, 吴迪, 丘文, 等. 输血对早产儿喂养不耐受及肠道菌群的影响[J]. 临床检验杂志, 2021, 39(8): 561-565.
[12] Healy, D.B., Ryan, C.A., Ross, R.P., Stanton, C. and Dempsey, E.M. (2022) Clinical Implications of Preterm Infant Gut Microbiome Development. Nature Microbiology, 7, 22-33. [Google Scholar] [CrossRef] [PubMed]
[13] Aziz, M., Prince, J.M. and Wang, P. (2022) Gut Microbiome and Necrotizing Enterocolitis: Understanding the Connection to Find a Cure. Cell Host Microbe, 30, 612-616. [Google Scholar] [CrossRef] [PubMed]
[14] Morrow, A.L., Lagomarcino, A.J., Schibler, K.R., et al. (2013) Early Microbial and Metabolomic Signatures Predict Later Onset of Necrotizing Enterocolitis in Preterm Infants. Micro-biome, 1, Article No. 13. [Google Scholar] [CrossRef] [PubMed]
[15] Pammi, M., Cope, J., Tarr, P., et al. (2017) Intestinal Dysbiosis in Preterm Infants Preceding Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis. Microbiome, 5, Article No. 31. [Google Scholar] [CrossRef] [PubMed]
[16] Lu, C.Y. and Ni, Y.H. (2015) Gutmicrobiota and the De-velopment of Pediatric Diseases. Journal of Gastroenterology, 50, 720-726. [Google Scholar] [CrossRef] [PubMed]
[17] Gritz, E.C. and Bhandari, V. (2015) The Human Neonatal Gut Microbiome: A Brief Review. Frontiers in Pediatrics, 3, Article 17. [Google Scholar] [CrossRef] [PubMed]
[18] 王超, 朱雪萍. 早产极低出生体重儿肠道菌群变化与坏死性小肠结肠炎的相关研究[J]. 国际儿科学杂志, 2022, 49(9): 620-624.
[19] Olm, M.R., Bhattacharya, N., Crits-Christoph, A., et al. (2019) Necrotizing Enterocolitis Is Pre-ceded by Increased Gut Bacterial Replication, Klebsiella, and Fimbriae-Encoding Bacteria. Science Advances, 5, eaax5727. [Google Scholar] [CrossRef] [PubMed]
[20] Pierrat, V., Marchand-Martin, L., Arnaud, C., et al. (2017) Neurode-velopmental Outcome at 2 Years for Preterm Children Born at 22 to 34 Weeks’ Gestation in France in 2011: EPIPAGE-2 Cohort Study. The BMJ, 358, j3448. [Google Scholar] [CrossRef] [PubMed]
[21] Maisonneuve, E., Lorthe, E., Torchin, H., et al. (2020) Association of Cho-rioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study. The Journal of Pediatrics, 222, 71-78.E6. [Google Scholar] [CrossRef] [PubMed]
[22] Hirschberger, R.G., Kuban, K.C.K., O’Shea, T.M., et al. (2018) Co-Occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm. Pediatric Neurology, 79, 45-52. [Google Scholar] [CrossRef] [PubMed]
[23] Lu, J., Yu, Y., Cluette-Brown, J., Martin, C.R. and Claud, E.C. (2018) Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice. Scientific Reports, 8, Article No. 5443. [Google Scholar] [CrossRef] [PubMed]
[24] Arentsen, T., Qian, Y., Gkotzis, S., et al. (2017) The Bacterial Peptidoglycan-Sensing Molecule Pglyrp2 Modulates Brain Development and Behavior. Molecular Psychiatry, 22, 257-266. [Google Scholar] [CrossRef] [PubMed]
[25] Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J.F. and Dinan, T.G. (2010) Effects of the Probiotic Bifidobacterium infantis in the Maternal Separation Model of Depression. Neuroscience, 170, 1179-1188. [Google Scholar] [CrossRef] [PubMed]
[26] Seki, D., Mayer, M., Hausmann, B., et al. (2021) Aberrant Gut-Microbiota-Immune-Brain Axis Development in Premature Neonates with Brain Damage. Cell Host & Microbe, 29, 1558-1572.E6. [Google Scholar] [CrossRef] [PubMed]
[27] 周林妫, 刘婵, 金海菊. 早期应用鼠李糖乳杆菌溶液对早产儿免疫功能及体格和智能发育的影响[J]. 中国妇幼保健, 2022, 37(4): 632-635. [Google Scholar] [CrossRef
[28] Hamvas, A., Feng, R., Bi, Y., et al. (2018) Exome Sequencing Identifies Gene Variants and Networks Associated with Extreme Respiratory Outcomes Following Preterm Birth. BMC Genetics, 19, Article No. 94. [Google Scholar] [CrossRef] [PubMed]
[29] Budden, K.F., Gellatly, S.L., Wood, D.L., et al. (2017) Emerging Pathogenic Links between Microbiota and the Gut-Lung Axis. Nature Reviews Microbiology, 15, 55-63. [Google Scholar] [CrossRef] [PubMed]
[30] Willis, K.A., Siefker, D.T., Aziz, M.M., et al. (2020) Perinatal Ma-ternal Antibioticexposure Augments Lung Injury in Offspring in Experimental Bronchopulmonary Dysplasia. American Journal of Physiology-Lung Cellular and Molecular Physiology, 318, L407-L418. [Google Scholar] [CrossRef] [PubMed]
[31] Wedgwood, S., Gerard, K., Halloran, K., et al. (2020) Intestinal Dysbiosis and the Developing Lung: The Role of Toll-Like Receptor 4 in the Gut-Lungaxis. Frontiers in Immunology, 11, Article 357. [Google Scholar] [CrossRef] [PubMed]
[32] Willis, K.A., Siefker, D.T., Aziz, M.M., et al. (2020) Perinatal Maternal Antibiotic Exposure Augments Lung Injury in Offspring in Experimental Bronchopulmonary Dysplasia. Amer-ican Journal of Physiology Lung Cellular and Molecular Physiology, 318, L407-L418. [Google Scholar] [CrossRef] [PubMed]
[33] Dickson, R.P., Singer, B.H., Newstead, M.W., et al. (2016) En-richment of the Lung Microbiome with Gut Bacteria in Sepsis and the Acute Respiratory Distress Syndrome. Nature Mi-crobiology, 1, Article No. 16113. [Google Scholar] [CrossRef] [PubMed]
[34] Chen, C.M., Chou, H.C., Yang, Y.S.H., et al. (2021) Predict-inghyperoxia-Induced Lung Injury from Associated Intestinal and Lungdysbiosis in Neonatal Mice. [Google Scholar] [CrossRef
[35] Chen, S., Lin, C. and Jan, M. (2021) Early Gut Microbiota Changes in Preterm Infants with Bronchopulmonary Dysplasia: A Pilot Case-Control Study. American Journal of Perinatology, 38, 1142-1149. [Google Scholar] [CrossRef] [PubMed]
[36] Ryan, F.J., Drew, D.P., Douglas, C., et al. (2019) Changes in the Composition of the Gut Microbiota and the Blood Transcriptome in Preterm Infants at Less than 29 Weeks Gestation Diagnosed with Bronchopulmonary Dysplasia. mSystems, 4, e00484-e00519. [Google Scholar] [CrossRef
[37] Shermadou, E.S. and Mavrogeorgos, G. (2018) Neonatal Sepsis. StatPearls Publishing LLC, Treasure Island.
[38] Madan, J.C., Salari, R.C., Saxena, D., et al. (2012) Gut Microbial Colonisation in Premature Neonates Predicts Neonatal Sepsis. ADC Fetal & Neonatal Edition, 97, F456-F462. [Google Scholar] [CrossRef] [PubMed]
[39] Chernikova, D.A., Madan, J.C., Housman, M.L., et al. (2018) The Premature Infant Gut Microbiome during the First 6 Weeks of Life Differs Based on Gestational Maturity at Birth. Pediatric Research, 84, 71-79. [Google Scholar] [CrossRef] [PubMed]
[40] Stewart, C.J., et al. (2017) Longitudinal Development of the Gut Microbiome and Metabolome in Preterm Neonates with Late Onset Sepsis and Healthy Controls. Microbiome, 5, Article No. 75. [Google Scholar] [CrossRef] [PubMed]
[41] Korpela, K., Blakstad, E.W., Moltu, S.J., et al. (2018) Intestinal Microbiota Development and Gestational Age in Preterm Neonates. Scientific Reports, 8, Article No. 2453. [Google Scholar] [CrossRef] [PubMed]
[42] Graspeuntner, S., Waschina, S., Künzel, S., et al. (2019) Gut Dysbiosis with Bacilli Dominance and Accumulation of Fermentation Products Precedes Late-Onset Sepsis in Preterm Infants. Clinical Infectious Disease, 69, 268-277. [Google Scholar] [CrossRef] [PubMed]
[43] 胡南非, 谭李红, 廖镇宇, 等. 肠道菌群与早产儿晚发型败血症关系的初步研究[J]. 中国医师杂志, 2022, 24(7): 1023-1027.