糖尿病患者应用胰岛素过敏机制及治疗的研究进展
Research Progress on the Mechanism and Treatment of Insulin Hypersensitivity in Di-abetic Patients
DOI: 10.12677/ACM.2023.13102194, PDF,   
作者: 侯鑫楠, 成曦爽, 魏剑芬:华北理工大学附属医院,河北 唐山
关键词: 糖尿病胰岛素过敏脱敏Diabetes Insulin Allergy Desensitization
摘要: 随着全球糖尿病患者的日益增多,胰岛素是最有效的方案,糖尿病患者在胰岛素使用过程中,发生过敏的情况也屡见不鲜,引发了人们对于“胰岛素过敏”的关注。从胰岛素应用至今,对于胰岛素过敏的研究也在进展。本文就目前胰岛素发生过敏机制的及治疗措施进展做一综述,指导临床对于这部分人群的诊疗。
Abstract: With the increasing number of diabetic patients in the world, insulin is the most effective program, and it is also common for diabetic patients to have allergies during the use of insulin, which has aroused people’s attention to “insulin allergy”. Since the application of insulin, the research on insu-lin allergy is also progressing. This article reviews the current mechanism of insulin allergy and the progress of treatment measures, and guides the clinical diagnosis and treatment of this group of people.
文章引用:侯鑫楠, 成曦爽, 魏剑芬. 糖尿病患者应用胰岛素过敏机制及治疗的研究进展[J]. 临床医学进展, 2023, 13(10): 15687-15692. https://doi.org/10.12677/ACM.2023.13102194

参考文献

[1] Zhou, B., Lu, Y., Hajifathalian, K., et al. (2016) Worldwide Trends in Diabetes Since 1980: A Pooled Analysis of 751 Population-Based Studies with 4•4 Million Participants. The Lancet, 387, 1513-1530. [Google Scholar] [CrossRef
[2] GBD 2016 Disease and Injury Incidence and Prevalence Collaborators (2017) Global, Regional, and National Incidence, Prevalence, and Years Lived with Disability for 328 Diseases and Injuries for 195 Countries, 1990-2016: A Systematic Analysis for the Global Burden of Disease Study 2016. The Lancet, 390, 1211-1259. [Google Scholar] [CrossRef
[3] Lovic, D., Piperidou, A., Zografou, I., et al. (2020) The Growing Epidemic of Diabetes Mellitus. Current Vascular Pharmacology, 18, 104-109. [Google Scholar] [CrossRef] [PubMed]
[4] 杨文英. 中国糖尿病的流行特点及变化趋势[J]. 中国科学: 生命科学, 2018, 48(8): 812-819.
[5] Rawshani, A., Rawshani, A. and Gudbjörnsdottir, S. (2017) Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes. The New England Journal of Medicine, 377, 300-301. [Google Scholar] [CrossRef
[6] March, C.A., Libman, I.M., Becker, D.J., et al. (2022) From Antiq-uity to Modern Times: A History of Diabetes Mellitus and Its Treatments. Hormone Research in Paediatrics, 95, 593-607. [Google Scholar] [CrossRef] [PubMed]
[7] 余学锋. 胰岛素的过去、现在和未来——胰岛素制剂发展与应用[J]. 中国医学前沿杂志(电子版), 2021, 13(6): 4-8.
[8] Pickup, J.C., Keen, H., Parsons, J.A., et al. (1978) Con-tinuous Subcutaneous Insulin Infusion: An Approach to Achieving Normoglycaemia. British Medical Journal, 1, 204-207. [Google Scholar] [CrossRef] [PubMed]
[9] Nimri, R., Nir, J. and Phillip, M. (2020) Insulin Pump Therapy. American Journal of Therapeutics, 27, e30-e41. [Google Scholar] [CrossRef
[10] National Institute for Health and Care Excellence: Guidelines (2015) Type 2 Diabetes in Adults: Management. National Institute for Health and Care Excellence (NICE), Lon-don.
[11] Haastrup, M.B., Henriksen, J.E., Mortz, C.G., et al. (2018) Insulin Allergy Can Be Successfully Managed by a Systematic Approach. Clinical and Translational Allergy, 8, Article No. 35. [Google Scholar] [CrossRef] [PubMed]
[12] Richardson, T. and Kerr, D. (2003) Skin-Related Complications of Insulin Therapy: Epidemiology and Emerging Management Strategies. American Journal of Clinical Dermatology, 4, 661-667. [Google Scholar] [CrossRef] [PubMed]
[13] Aberumand, B. and Jeimy, S. (2021) The Complexities of Insulin Allergy: A Case and Approach. Allergy, Asthma & Clinical Immunology, 17, Article No. 79. [Google Scholar] [CrossRef] [PubMed]
[14] Ghazavi, M.K. and Johnston, G.A. (2011) Insulin Allergy. Clin-ics in Dermatology, 29, 300-305. [Google Scholar] [CrossRef] [PubMed]
[15] Baur, X., Bossert, J. and Koops, F. (2003) IgE-Mediated Allergy to Recombinant Human Insulin in a Diabetic. Allergy, 58, 676-678. [Google Scholar] [CrossRef] [PubMed]
[16] Nagy, E., Komlósi, Z.I., Márton, D.F., et al. (2020) Inzulin-túlérzékenységi reakció vagy valami más? Tanulságok egy eset kapcsán. Orvosi Hetilap, 161, 1483-1487. [Google Scholar] [CrossRef] [PubMed]
[17] Kim, D. and Baraniuk, J. (2007) Delayed-Type Hypersensitivity Re-action to the Meta-Cresol Component of Insulin. Annals of Allergy, Asthma & Immunology, 99, 194-195. [Google Scholar] [CrossRef
[18] Porsche, R. and Brenner, Z.R. (1999) Allergy to Protamine Sulfate. Heart Lung, 28, 418-428. [Google Scholar] [CrossRef
[19] Roest, M.A., Shaw, S. and Orton, D.I. (2003) Insu-lin-Injection-Site Reactions Associated with Type I Latex Allergy. The New England Journal of Medicine, 348, 265-266. [Google Scholar] [CrossRef
[20] 袁晓勇, 高莹, 张俊清, 等. 14例胰岛素类似物过敏的病例报道及文献复习[J]. 中国糖尿病杂志, 2015, 23(9): 832-835.
[21] Heinzerling, L. (2013) Insulin Allergy. Diabetic Medicine, 30, 891-892. [Google Scholar] [CrossRef] [PubMed]
[22] Akinci, B., Yener, S., Bayraktar, F., et al. (2010) Allergic Reactions to Human Insulin: A Review of Current Knowledge and Treatment Options. Endocrine, 37, 33-39. [Google Scholar] [CrossRef] [PubMed]
[23] Heinzerling, L., Raile, K., Rochlitz, H., et al. (2008) Insulin Al-lergy: Clinical Manifestations and Management Strategies. Allergy, 63, 148-155. [Google Scholar] [CrossRef] [PubMed]
[24] Jacquier, J., Chik, C.L. and Senior, P.A. (2013) A Practical, Clinical Approach to the Assessment and Management of Suspected Insulin Allergy. Diabetic Medicine, 30, 977-985. [Google Scholar] [CrossRef] [PubMed]
[25] 程庆丰, 张素华, 任伟, 等. 胰岛素泵脱敏治疗多种胰岛素制剂过敏患者1例[J]. 中国糖尿病杂志, 2010, 18(11): 876-877.
[26] Léonet, J., Malaise, J., Goffin, E., et al. (2006) Solitary Pancreas Transplantation for Life-Threatening Allergy to Human Insulin. Transplant International, 19, 474-477. [Google Scholar] [CrossRef] [PubMed]
[27] Yong, P.F., Malik, R., Arif, S., et al. (2009) Rituximab and Omalizumab in Severe, Refractory Insulin Allergy. The New England Journal of Medicine, 360, 1045-1047. [Google Scholar] [CrossRef
[28] Radermecker, R.P. and Scheen, A.J. (2007) Allergy Reactions to In-sulin: Effects of Continuous Subcutaneous Insulin Infusion and Insulin Analogues. Diabetes/Metabolism Research and Reviews, 23, 348-355. [Google Scholar] [CrossRef] [PubMed]
[29] Krishna, M.T. and Huissoon, A.P. (2011) Clinical Immunology Review Se-ries: An Approach to Desensitization. Clinical & Experimental Immunology, 163, 131-146. [Google Scholar] [CrossRef] [PubMed]
[30] Yuan, T., Zhao, W., Wang, L., et al. (2016) Continuous Subcutaneous Insulin Infusion as an Effective Method of Desensitization Therapy for Diabetic Patients with Insulin Al-lergy: A 4-Year Single-Center Experience. Clinical Therapeutics, 38, 2489-2494.e2481. [Google Scholar] [CrossRef] [PubMed]
[31] 李理总, 陶依然, 宋荣景, 等. 胰岛素过敏患者脱敏治疗文献分析[J]. 临床药物治疗杂志, 2021, 19(5): 26-31.