TSHR基因甲基化与PTC的关系研究
Relationship between TSHR Gene Methylation and PTC
DOI: 10.12677/WJCR.2023.134021, PDF,    科研立项经费支持
作者: 于 波, 徐 宁*, 孙玺媛, 樊伟业, 姚佳兴, 李松埔, 窦福林, 李 扬：齐齐哈尔市第一医院甲状腺外科，黑龙江 齐齐哈尔
关键词: 促甲状腺激素受体；甲状腺乳头状癌；基因突变；甲基化；Thyrotropin Receptor； Papillary Thyroid Carcinoma； Genemutation； Methylation
摘要: 甲状腺癌是头颈部较为常见的恶性肿瘤，发病率在全球范围内呈上升趋势，病理类型以甲状腺乳头状癌(Papillary Thyroid Carcinoma, PTC)最为常见。促甲状腺激素受体(Thyroid Stimulating Hormone Receptor, TSHR)是甲状腺特异蛋白，促甲状腺激素受体基因是PTC的抑癌基因，其编码基因启动子高甲基化会引起TSHR功能异常，从而影响甲状腺功能改变，导致甲状腺疾病发生。研究表明，TSHR基因启动子高甲基化可能与PTC发病机制密切相关。现就TSHR编码基因甲基化在PTC中的研究予以综述。
Abstract: Thyroid carcinoma is a common malignant tumor in head and neck, the incidence of which is on the rise in the world. The most common pathological type is papillary thyroid carcinoma (PTC). Thyroid stimulating hormone receptor (TSHR) is a thyroid-specific protein, and the TSHR gene is a tumor suppressor gene of PTC. Hypermethylation of the promoter of its coding gene can cause abnormal function of TSHR, thus affecting the thyroid function changes, leading to thyroid disease. Studies have shown that TSHR gene promoter hypermethylation may be closely related to the pathogenesis of PTC. This article reviews the research on methylation of TSHR coding gene in PTC.
文章引用：于波, 徐宁, 孙玺媛, 樊伟业, 姚佳兴, 李松埔, 窦福林, 李扬. TSHR基因甲基化与PTC的关系研究[J]. 世界肿瘤研究, 2023, 13(4): 150-154. https://doi.org/10.12677/WJCR.2023.134021

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