高脂饮食对眼部影响的研究进展
Progress of Research on Effects of High-Fat Diet on Eye
DOI: 10.12677/ACM.2023.13102225, PDF,    科研立项经费支持
作者: 万梓菡：青海大学研究生院眼科，青海 西宁；李 娜*：青海大学附属医院眼科，青海 西宁
关键词: 高脂饮食；动物模型；眼表；视网膜；High Fat Diet； Animal Models； Ocular Surface； Retina
摘要: 高脂饮食(High fat diet, HFD)会引起脂质代谢紊乱、肥胖等疾病，严重影响人类的健康；同时还会引起年龄相关性黄斑变性(age-related macular degeneration, AMD)、糖尿病性视网膜病变(diabetic retinopathy, DR)等眼部相关疾病，从而导致视力障碍。目前高脂饮食动物模型已被广泛应用研究，该类模型主要用于研究高脂饮食引起的相关疾病的病理生理机制，更有效地认识对HFD引起的视网膜眼部相关疾病的早期预防和治疗措施。本文综述了近几年来有关高脂饮食动物模型对眼部影响的研究进展，主要是从HFD的成分、HFD动物模型的构建，以及HFD对泪腺、睑板腺、角膜及视网膜的影响等方面进行综述。
Abstract: High fat diet (HFD) can cause disorders of lipid metabolism, obesity and other diseases, which seri-ously affect human health. At the same time, it also causes age related macular degeneration (AMD), diabetic retinopathy (DR) and other eye related diseases, which can lead to visual impairment. At present, animal models of high fat diet have been widely used to study the pathophysiological mechanism of related diseases caused by high fat diet, so as to more effectively understand the ear-ly prevention and treatment of retina-eye diseases caused by HED. In this paper, we review the re-search progress on the effects of high-fat diet animal models on the eyes in recent years, mainly from the components of high fat diet, the construction of animal models of high fat diet, and the ef-fects of high fat diet on lacrimal gland, meibomian gland, cornea and retina.
文章引用：万梓菡, 李娜. 高脂饮食对眼部影响的研究进展[J]. 临床医学进展, 2023, 13(10): 15918-15925. https://doi.org/10.12677/ACM.2023.13102225

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