microRNA-375在肝细胞癌中的研究热点及发展趋势——基于文献计量与可视化分析

Research Hotspots and Development Trend of microRNA-375 in Hepatocellular Carcinoma—Based on Bibliometric and Visualization Analysis

摘要: 目的：运用文献计量方法分析microRNA-375在肝细胞癌中的研究现状、热点及发展趋势，为该领域未来研究提供数据参考。方法：基于Web of Science核心合集中2013~2022年有关microRNA-375在肝细胞癌中的相关研究数据，利用可视化分析软件CiteSpace和VOSviewer对文献年度发表量、国家、研究机构、来源期刊、活跃作者及关键词进行文献计量和可视化分析。结果：截至2023年9月15日，共有46,808篇microRNA-375与肝细胞癌的相关研究发表。文献发表量呈逐年上升趋势，中国是最高产的国家，其次是美国和日本，法国中心性最高。Oncotarget发文量最高，Hepatology被引用频次最高。高发文量机构主要集中在中国，Sun Yat-sen University发文量最多，University of California System中心性位列第一。此外，“open label”、“tumor microenvironment”、“phase iii”、“immune checkpoint inhibitors”、“immune infiltration”、“microenvironment”等是该领域的研究热点。结论：本研究通过文献计量分析方法对microRNA-375与肝细胞癌进行了全面概述，为关注该领域的科研人员提供线索。

Abstract: Objective: To analyze the current research status, hotspots, and development trend of mi-croRNA-375 in hepatocellular carcinoma using bibliometric methods, and to provide data reference for future research in this field. Methods: Based on the data of relevant studies about mi-croRNA-375 in hepatocellular carcinoma from 2013-2022 in the Web of Science Core Collection, bibliometric and visualization analyses were performed using the visual analysis software CiteSpace and VOSviewer to analyze the literature’s annual publication volume, countries, research institu-tions, source journals, active authors, and keywords. Results: As of September 15, 2023, a total of 46,808 studies related to microRNA-375 and hepatocellular carcinoma were published. Literature publication showed an increasing trend from year to year, with China being the most prolific coun-try, followed by the United States and Japan, with France having the highest centrality. Oncotarget had the highest number of publications, and Hepatology had the highest citation frequency. Institu-tions with high publication volume are mainly concentrated in China, Sun Yat-sen University has the highest publication volume, and University of California System is ranked first in terms of centrality. In addition, “open label”, “tumor microenvironment”, “phase iii”, “immune checkpoint inhibitors”, “immune infiltration”, “microenvironment”, “immune checkpoint inhibitors”, “immune infiltration”, “microenvironment”, etc. are the research hotspots in this field. Conclusion: This study provides a comprehensive overview of microRNA-375 and hepatocellular carcinoma by means of bibliometric analysis to provide clues for researchers focusing on this field.