铁死亡在骨关节炎中潜在作用的研究新进展
Recent Advances in the Study of Ferroptosis’ Potential Role in Osteoarthritis
DOI: 10.12677/ACM.2023.13102249, PDF,   
作者: 刘洪江*：新疆医科大学第五临床医学院，新疆 乌鲁木齐；崔 泳#：新疆医科大学第五临床医学院，新疆 乌鲁木齐；新疆医科大学第五附属医院骨科中心，新疆 乌鲁木齐
关键词: 骨关节炎；软骨细胞；铁死亡；Osteoarthritis； Chondrocytes； Ferroptosis
摘要: 近年来铁死亡在不同疾病领域中开辟新的平台，发现它在不同疾病的发生进展过程中有着重要意义。骨关节炎(osteoarthrosis, OA)最早的病理改变常见于关节软骨表面，软骨细胞(软骨中存在的唯一细胞类型)发生凋亡或者死亡是其主要特征。铁死亡作为一种新型细胞死亡形式，由铁依赖性脂质过氧化导致，在骨关节炎软骨细胞调节性死亡中起关键作用。本文将汇总近年来关于铁死亡的研究最新进展，以旨在探究铁死亡在骨关节炎中的潜在作用，可能有助于更好地针对性地进行适当的治疗，以帮助减轻症状并改善功能。
Abstract: In recent years, ferroptosis has emerged as a new platform in various disease domains, revealing its significant role in the progression of different diseases. The earliest pathological changes in osteo-arthritis (OA) are commonly found on the surface of articular cartilage. Apoptosis or death of chon-drocytes, the only type of cell present in cartilage, is a major characteristic. Ferroptosis, a new form of cell death caused by iron-dependent lipid peroxidation, plays a crucial role in the regulated death of chondrocytes in osteoarthritis. This article will summarize the latest research advancements on ferroptosis with the aim of exploring its potential role in osteoarthritis. Such understanding may aid in more targeted and appropriate treatments to help alleviate symptoms and improve function.
文章引用：刘洪江, 崔泳. 铁死亡在骨关节炎中潜在作用的研究新进展[J]. 临床医学进展, 2023, 13(10): 16100-16106. https://doi.org/10.12677/ACM.2023.13102249

参考文献

[1] Hunter, D.J., March, L. and Chew, M. (2020) Osteoarthritis in 2020 and Beyond: A Lancet Commission. The Lancet (London, England), 396, 1711-1712. [Google Scholar] [CrossRef] 
[2] Long, H., Liu, Q., Yin, H., et al. (2022) Prevalence Trends of Site-Specific Osteoarthritis from 1990 to 2019: Findings from the Global Burden of Disease Study 2019. Arthritis & Rheumatology (Hoboken, N.J.), 74, 1172-1183. [Google Scholar] [CrossRef] [PubMed]
[3] Neogi, T. (2013) The Epidemiology and Impact of Pain in Osteoarthritis. Osteoarthritis and Cartilage, 21, 1145-1153. [Google Scholar] [CrossRef] [PubMed]
[4] Adams, C.S. and Horton, W.E. (1998) Chondrocyte Apoptosis In-creases with Age in the Articular Cartilage of Adult Animals. The Anatomical Record, 250, 418-425. [Google Scholar] [CrossRef] 
[5] Dixon, S.J., Lemberg, K.M., Lampsrecht, M.R., et al. (2012) Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death. Cell, 149, 1060-1072. [Google Scholar] [CrossRef] [PubMed]
[6] Chang, S., Tang, M., Zhang, B., et al. (2022) Ferropto-sis in Inflammatory Arthritis: A Promising Future. Frontiers in Immunology, 13, Article ID: 955069. [Google Scholar] [CrossRef] [PubMed]
[7] Yao, X., Sun, K., Yu, S., et al. (2021) Chondrocyte Ferroptosis Contribute to the Progression of Osteoarthritis. Journal of Orthopaedic Translation, 27, 33-43. [Google Scholar] [CrossRef] [PubMed]
[8] Dolma, S., Lessnick, L.S., Hahn, C.W., et al. (2003) Identification of Genotype-Selective Antitumor Agents Using Synthetic Lethal Chemical Screening in Engineered Human Tumor Cells. Cancer Cell, 3, 285-296. [Google Scholar] [CrossRef] 
[9] Lei, T., Qian, H., Lei, P., et al. (2021) Ferroptosis-Related Gene Signature Associates with Immunity and Predicts Prognosis Accurately in Patients with Osteosarcoma. Cancer Science, 112, 4785-4798. [Google Scholar] [CrossRef] [PubMed]
[10] Yagoda, N., von Rechenberg, M., Zaganjor, E., et al. (2007) RAS-RAF-MEK-Dependent Oxidative Cell Death Involving Voltage-Dependent Anion Channels. Nature, 447, 865-869. [Google Scholar] [CrossRef] [PubMed]
[11] 张婧, 孙辉, 朱礼军, 等. 大鼠缺血性脑卒中早期miR-27a表达与铁死亡的关系[J]. 天津医药, 2022, 50(6): 595-600.
[12] 王君君, 李坚. 槲皮素通过抑制溶质载体家族7成员11表达诱导前列腺癌细胞铁死亡的临床研究[J]. 中国性科学, 2022, 31(9): 42-46.
[13] 杨浩, 刘之谦, 毕涛, 等. PTBP1对肝癌细胞铁死亡的影响和机制研究[J]. 中国现代普通外科进展, 2022, 25(2): 85-89.
[14] Zhang, J., Wang, X., Guan, B., et al. (2022) Qing-Xin-Jie-Yu Granule Inhibits Ferroptosis and Stabilizes Atherosclerotic Plaques by Regulating the GPX4/xCT Signaling Pathway. Journal of Ethnopharmacology, 301, Article ID: 115852. [Google Scholar] [CrossRef] [PubMed]
[15] Bao, Z., Liu, Y., Chen, B., et al. (2021) Prokineticin-2 Prevents Neuronal Cell Deaths in a Model of Traumatic Brain Injury. Nature Communications, 12, Article No. 4420. [Google Scholar] [CrossRef] [PubMed]
[16] Ju, L., Shi, Y. and Liu, G. (2022) Identification and Validation of a Ferroptosis-Related lncRNA Signature to Robustly Predict the Prognosis, Immune Microenvironment, and Immuno-therapy Efficiency in Patients with Clear Cell Renal Cell Carcinoma. PeerJ, 10, E14506. [Google Scholar] [CrossRef] [PubMed]
[17] Zhang, Y., Swanda, R.V., et al. (2021) mTORC1 Couples Cyst(e)ine Availability with GPX4 Protein Synthesis and Ferroptosis Regulation. Nature Communications, 12, Article No. 1589. [Google Scholar] [CrossRef] [PubMed]
[18] Bao, Z., Hua, L., Ye, Y., et al. (2021) MEF2C Silencing Downregulates NF2 and E-Cadherin and Enhances Erastin-Induced Ferroptosis in Meningioma. Neuro-Oncology, 23, 2014-2027. [Google Scholar] [CrossRef] [PubMed]
[19] Yang, W.S., SriRamaratnam, R., Welsch, M.E., et al. (2014) Regulation of Ferroptotic Cancer Cell Death by GPX4. Cell, 156, 317-331. [Google Scholar] [CrossRef] [PubMed]
[20] Lee, H., Zandkarimi, F., Zhang, Y., et al. (2020) Ener-gy-Stress-Mediated AMPK Activation Inhibits Ferroptosis. Nature Cell Biology, 22, 225-234. [Google Scholar] [CrossRef] [PubMed]
[21] Miotto, G., Rossetto, M., Di Paolo, M.L., et al. (2019) Insight in-to the Mechanism of Ferroptosis Inhibition by Ferrostatin-1. Redox Biology, 28, Article ID: 101328. [Google Scholar] [CrossRef] [PubMed]
[22] Miao, Y., Chen, Y., Xue, F., et al. (2022) Contribution of Fer-roptosis and GPX4’s Dual Functions to Osteoarthritis Progression. EBioMedicine, 76, Article ID: 103847. [Google Scholar] [CrossRef] [PubMed]
[23] Simão, M., Gavaia, P.J., Camacho, A., et al. (2019) Intracellular Iron Uptake Is Favored in Hfe-KO Mouse Primary Chondrocytes Mimicking an Osteoarthritis-Related Phenotype. Bio-Factors, 45, 583-597. [Google Scholar] [CrossRef] [PubMed]
[24] Parelman, M., Stoecker, B., Baker, A., et al. (2006) Iron Restriction Nega-tively Affects Bone in Female Rats and Mineralization of hFOB Osteoblast Cells. Experimental Biology and Medicine, 231, 378-386. [Google Scholar] [CrossRef] [PubMed]
[25] Ma, S., Dubin, A.E., Zhang, Y., et al. (2021) A Role of PIEZO1 in Iron Metabolism in Mice and Humans. Cell, 184, 969-982. [Google Scholar] [CrossRef] [PubMed]
[26] Aron, A.T., Loehr, M.O., Bogena, J., et al. (2016) An Endoperox-ide Reactivity-Based FRET Probe for Ratiometric Fluorescence Imaging of Labile Iron Pools in Living Cells. Journal of the American Chemical Society, 138, 14338-14346. [Google Scholar] [CrossRef] [PubMed]
[27] Wang, X., et al. (2015) Iron Overload Increases Osteoclastogenesis and Aggravates the Effects of Ovariectomy on Bone Mass. Journal of Endocrinology, 226, 121-134. [Google Scholar] [CrossRef] 
[28] Ge, W., Jie, J., Yao, J., et al. (2022) Advanced Glycation end Products Promote Osteoporosis by Inducing Ferroptosis in Osteoblasts. Molecular Medicine Reports, 25, Article No. 140. [Google Scholar] [CrossRef] [PubMed]
[29] Tsay, J., Yang, Z., Ross, F.P., et al. (2010) Bone Loss Caused by Iron Overload in a Murine Model: Importance of Oxidative Stress. Blood, 116, 2582-2589. [Google Scholar] [CrossRef] [PubMed]
[30] Ni, S., Yuan, Y., Qian, Z., et al. (2021) Hypoxia Inhibits RANKL-Induced Ferritinophagy and Protects Osteoclasts from Ferroptosis. Free Radical Biology and Medicine, 169, 271-282. [Google Scholar] [CrossRef] [PubMed]
[31] Qu, X., Sun, Z., Wang, Y. and Ong, H. (2021) Zoledronic Acid Promotes Osteoclasts Ferroptosis by Inhibiting FBXO9-Mediated p53 Ubiquitination and Degradation. PeerJ, 9, e12510. [Google Scholar] [CrossRef] [PubMed]
[32] Yazar, M., Sarban, S., Kocyigit, A. and Isikan, U.E. (2005) Synovial Fluid and Plasma Selenium, Copper, Zinc, and Iron Concentrations in Patients with Rheumatoid Arthri-tis and Osteoarthritis. Biological Trace Element Research, 106, 123-132. [Google Scholar] [CrossRef] 
[33] Jing, X., Du, T., Li, T., et al. (2021) The Detrimental Effect of Iron on OA Chondrocytes: Importance of Pro-Inflammatory Cytokines Induced Iron Influx and Oxidative Stress. Journal of Cellular and Molecular Medicine, 25, 5671-5680. [Google Scholar] [CrossRef] [PubMed]
[34] Dixon, S.J., Patel, D.N., Welsch, M., et al. (2014) Pharmacological Inhibition of Cystine-Glutamate Exchange Induces Endoplasmic Retic-ulum Stress and Ferroptosis. eLife, 3, e02523. [Google Scholar] [CrossRef] 
[35] Neitemeier, S., Jelinek, A., Laino, V., et al. (2017) BID Links Ferroptosis to Mitochondrial Cell Death Pathways. Redox Biology, 12, 558-570. [Google Scholar] [CrossRef] [PubMed]
[36] Gao, M., Yi, J., Zhu, J., et al. (2018) Role of Mitochondria in Ferroptosis. Molecular Cell, 73, 354-363. [Google Scholar] [CrossRef] [PubMed]
[37] Jing, X., Lin, J., Du, T., et al. (2021) Iron Overload Is Associat-ed with Accelerated Progression of Osteoarthritis: The Role of DMT1 Mediated Iron Homeostasis. Frontiers in Cell and Developmental Biology, 8, Article ID: 594509. [Google Scholar] [CrossRef] [PubMed]
[38] Knäuper, V., Cowell, S., Smith, B., et al. (1997) The Role of the C-terminal Domain of Human Collagenase-3 (MMP-13) in the Activation of Procollagenase-3, Substrate Specificity, and Tissue Inhibitor of Metalloproteinase Interaction. Journal of Biological Chemistry, 272, 7608-7616. [Google Scholar] [CrossRef] [PubMed]
[39] Lin, Z., Song, J., Gao, Y., et al. (2022) Hypoxia-Induced HIF-1α/lncRNA-PMAN Inhibits Ferroptosis by Promoting the Cytoplasmic Translocation of ELAVL1 in Peritoneal Dissemination from Gastric Cancer. Redox Biology, 52, Article ID: 102312. [Google Scholar] [CrossRef] [PubMed]
[40] Torretta, S., Scagliola, A., Ricci, L., et al. (2020) D-Mannose Suppresses Macrophage IL-1β Production. Nature Communications, 11, Article No. 6343. [Google Scholar] [CrossRef] [PubMed]
[41] Zhou, X., Zheng, Y., Sun, W., et al. (2021) D-Mannose Allevi-ates Osteoarthritis Progression by Inhibiting Chondrocyte Ferroptosis in a HIF-2α-Dependent Manner. Cell Prolifera-tion, 54, e13134. [Google Scholar] [CrossRef] [PubMed]
[42] Sheng, B., Li, X., Zhou, L., et al. (2020) Targeting miR-10a-5p/IL-6R Axis for Reducing IL-6-Induced Cartilage Cell Ferroptosis. Experimental and Molecular Pathology, 118, Article ID: 104570. [Google Scholar] [CrossRef] [PubMed]
[43] Liu, P., Feng, Y., Li, H., et al. (2020) Ferrostatin-1 Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting Ferroptosis. Cellular & Molecular Biology Letters, 25, Ar-ticle No. 10. [Google Scholar] [CrossRef] [PubMed]

为你推荐