新生儿急性呼吸窘迫综合征研究进展
Research Progress of Neonatal Acute Respiratory Distress Syndrome
摘要: 新生儿急性呼吸窘迫综合征(ARDS)是一种快速的进行性呼吸困难，顽固性低氧性为特点的呼吸功能障碍，主要是直接或间接肺损伤后肺泡毛细血管壁破坏，肺顺应性下降所致，是一种病因和发病机制较复杂的临床综合征，是造成新生儿死亡和致残的主要原因之一。目前针对新生儿ARDS的治疗已取得重大进展，包括产前使用糖皮质激素预防、PS替代、呼吸支持、液体管理和营养支持等，尚无针对新生儿ARDS高效的、安全的临床治疗方案。现就新生儿ARDS诊断标准的演变、发病机制和病因、临床特点、目前治疗策略等方面的研究进展予以综述。
Abstract: Neonatal acute respiratory distress syndrome (ARDS) is a respiratory dysfunction characterized by rapidly progressive dyspnea and refractory hypoxia. It is mainly caused by the destruction of alve-olar capillary walls and decreased lung compliance after direct or indirect lung injury. It is a clinical syndrome with complex etiology and pathogenesis, and is one of the main causes of neonatal death and disability. Currently, significant progress has been made in the treatment of neonatal ARDS, in-cluding the use of prenatal glucocorticoids for prevention. There is no efficient and safe clinical treatment plan for neonatal ARDS such as PS replacement, respiratory support, fluid management and nutritional support. This article reviews the research progress in the evolution of diagnostic criteria, pathogenesis, etiology, clinical characteristics and current treatment strategies of neonatal ARDS.
文章引用：高韩红, 姜泓. 新生儿急性呼吸窘迫综合征研究进展[J]. 临床医学进展, 2023, 13(10): 16107-16112. https://doi.org/10.12677/ACM.2023.13102250

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