舒芬太尼、纳布啡及氢吗啡酮在腹腔镜术后PCIA的临床研究现状
Clinical Research Status of Sufentanil, Nalbuphine and Hydromorphone in PCIA af-ter Laparoscopic Surgery
DOI: 10.12677/ACM.2023.13102254, PDF,    科研立项经费支持
作者: 李 玲:内蒙古医科大学第一临床医学院,内蒙古 呼和浩特;武丽芳*:内蒙古医科大学附属医院麻醉科,内蒙古 呼和浩特
关键词: 舒芬太尼纳布啡氢吗啡酮患者自控静脉镇痛腹腔镜手术Sufentanil Nalbuphine Hydromorphone Patient Controlled Intravenous Analgesia Laparoscopy
摘要: 内窥镜技术飞速发展,在我国外科手术量中占据着相当大的比例。术后疼痛几乎存在于所有手术患者,阿片类药物一直是临床疼痛治疗的主导用药,但其固有的副作用经常限制着止痛质量。本文旨在综述腹腔镜术后PCIA常用镇痛药物研究现状,并且对临床术后镇痛用药新思路、新观点进行了总结,以期在有效镇痛的基础上降低腹腔镜术后不良反应的发生率,完善腹部腹腔镜术后镇痛,为临床术后镇痛合理化用药及进一步研究提供参考。
Abstract: The rapid development of endoscopic technology accounts for a considerable proportion of surgical operations in China. Postoperative pain exists in almost all surgical patients. Opioids have always been the dominant drug in clinical pain treatment, but their inherent side effects often limit the quality of pain relief. The purpose of this paper is to summarize the research status of commonly used analgesic drugs for PCIA after laparoscopic surgery, and summarize the new ideas and new viewpoints of clinical postoperative analgesic drugs, in order to reduce the incidence of adverse re-actions after laparoscopic surgery on the basis of effective analgesia, improve postoperative analge-sia after abdominal laparoscopy, and provide reference for rational drug use and further research of clinical postoperative analgesia.
文章引用:李玲, 武丽芳. 舒芬太尼、纳布啡及氢吗啡酮在腹腔镜术后PCIA的临床研究现状[J]. 临床医学进展, 2023, 13(10): 16130-16134. https://doi.org/10.12677/ACM.2023.13102254

参考文献

[1] 褚光迪, 牛海涛. 手术机器人发展史和展望[J]. 泌尿外科杂志(电子版), 2023, 15(1): 56-60. [Google Scholar] [CrossRef
[2] Yamanaga, S., Posselt, A.M., Freise, C.E., et al. (2017) A Single Perioperative Injection of Dexamethasone Decreases Nausea, Vomiting, and Pain after Laparoscopic Donor Nephrectomy. Journal of Transplantation, 2017, Article ID: 3518103. [Google Scholar] [CrossRef] [PubMed]
[3] Lee, H.M., Kil, H.K., Koo, B.N., et al. (2020) Comparison of Sufentan-il- and Fentanyl-Based Intravenous Patient-Controlled Analgesia on Postoperative Nausea and Vomiting after Laparo-scopic Nephrectomy: A Prospective, Double-Blind, Randomized-Controlled Trial. International Journal of Medical Sci-ences, 17, 207-213. [Google Scholar] [CrossRef] [PubMed]
[4] Jänig, W. and Häuser, W. (2014) Viszerale Schmerzen. Schmerz, 28, 230-232. [Google Scholar] [CrossRef] [PubMed]
[5] Pasternak, G.W. (2005) Molecular Biology of Opioid Analgesia. Journal of Pain and Symptom Management, 29, S2-S9. [Google Scholar] [CrossRef] [PubMed]
[6] 史琪清, 李成, 陈国忠. 急性术后内脏痛的防治进展[J]. 国际麻醉学与复苏杂志, 2023, 44(6): 657-661. [Google Scholar] [CrossRef
[7] Sun, Z.T., Zhu, Z.F., Yang, G.Y., et al. (2020) The 95% Effective Dose of Nalbuphine in Patient-Controlled Intravenous Analgesia for Patients Undergoing Laparo-scopic Total Hysterectomy Compared to equivalent Sufentanil: Retraction. Medicine, 99, e20424. [Google Scholar] [CrossRef
[8] Xi, M.Y., Li, S.S., Zhang, C., et al. (2020) Nalbuphine for Analgesia After Orthognathic Surgery and Its Effect on Postoperative Inflammatory and Oxidative Stress: A Randomized Double-Blind Controlled Trial. Journal of Oral and Maxillofacial Surgery, 78, 528-537. [Google Scholar] [CrossRef] [PubMed]
[9] Deng, C., Wang, X., Zhu, Q., et al. (2017) Comparison of Nalbu-phine and Sufentanil for Colonoscopy: A Randomized Controlled Trial. PLOS ONE, 12, e0188901. [Google Scholar] [CrossRef] [PubMed]
[10] Huang, C.-Y., Yang, S.-X., Xu, M.-J., et al. (2020) A Compar-ative Study of Three Concentrations of Intravenous Nalbuphine Combined with Hydromorphone for Post-Cesarean De-livery Analgesia. Chinese Medical Journal, 133, 523-529. [Google Scholar] [CrossRef
[11] Chen, J.W., Tian, L., Zhang, L., Hu, J.Y., Huang, S.Q. and Jiao, J. (2021) Nalbuphine on Postoperative Gastrointestinal Tract Dysfunction after Laparoscopic Surgery for Gynaeco-logical Malignancies: A Randomized Controlled Trial. Clinical and Experimental Pharmacology and Physiology, 48, 170-176. [Google Scholar] [CrossRef] [PubMed]
[12] Jiang, Q., Zhang, R. and Liu, T. (2020) Effect of Nalbu-phine on Patient Controlled Intravenous Analgesia after Radical Resection of Colon Cancer. Oncology Letters, 19, 2533-2538. [Google Scholar] [CrossRef] [PubMed]
[13] Nie, Z.B., Li, Z.H., Lu, B., Guo, Y.Y. and Zhang, R. (2022) Hydromorphone vs Sufentanil in Patient-Controlled Analgesia for Postoperative Pain Management: A Meta-Analysis. Medicine (Baltimore), 101, e28615. [Google Scholar] [CrossRef
[14] Tsai, H.L., Chang, T.K., Su, W.C., et al. (2019) Comparing Efficacy and Safety between Naldebain® and Intravenous Patient-Controlled Analgesia with Fentanyl for Pain Manage-ment Post-Laparotomy: Study Protocol for a Randomized Controlled, Non-Inferior trial. Trials, 20, Article No. 173. [Google Scholar] [CrossRef] [PubMed]
[15] 邓玉辉. 氢吗啡酮用于腹腔镜手术后患者自控静脉镇痛的效果[J]. 中国医药科学, 2019, 9(3): 104-106.
[16] Liu, J., Wang, Y., Tang, Y., et al. (2020) Clinical Effect and Safety Evaluation of Hydromorphone Combined with Sufentanil in Patient-Controlled Intravenous Analgesia for Patients with Hepatocellular Cancer and Its Effect on Serum Immune Factors. Oncology Letters, 20, Article No. 296. [Google Scholar] [CrossRef] [PubMed]
[17] Wang, L., Johnston, B., Kaushal, A., et al. (2016) Ketamine Added to Morphine or Hydromorphone Patient-Controlled Analgesia for Acute Postoperative Pain in Adults: A Systematic Review and Meta-Analysis of Randomized Trials. Canadian Journal of Anesthesia, 63, 311-325. [Google Scholar] [CrossRef] [PubMed]
[18] Wehrfritz, A., Ihmsen, H., Fuchte, T., et al. (2020) Postoperative Pain Therapy with Hydromorphone; Comparison of Patient-Controlled Analgesia with Target-Controlled Infusion and Standard Patient-Controlled Analgesia: A Randomised Controlled Trial. European Journal of Anaesthesiology, 37, 1168-1175. [Google Scholar] [CrossRef
[19] 蓝沁舟, 方芳, 仓静. 阿片类药物及其使用的新进展[J]. 中国临床医学, 2023, 30(4): 736-742.