抗LGI1抗体相关脑炎一例病例报道并文献复习
Antibody LGI1 Autoimmune Encephalitis: A Case Report and Literature Review
DOI: 10.12677/ACM.2023.13102262, PDF,    国家自然科学基金支持
作者: 刘 悦, 张晓蒙, 杨绍楠*：青岛大学附属医院神经内科，山东 青岛；李翠萍：青岛大学附属医院重症医学科，山东 青岛；田新涛：青岛大学附属医院泌尿外科，山东 青岛
关键词: 自身免疫性脑炎；桥本甲状腺炎；LGI1；免疫治疗；Autoimmune Encephalitis； Hashimoto’s Thyroiditis； LGI1； Immunotherapy
摘要: 自身免疫性脑炎是一种罕见的神经系统炎症性疾病，自2005年首次报道了N-甲基-D-天冬氨酸(NMDA)抗体脑炎后，已经描述了数量惊人的新型致病抗体。根据抗体不同，自身免疫性脑炎分为不同类型，抗富亮氨酸胶质瘤灭活1 (LGI1)抗体相关性脑炎是自身免疫性脑炎的一种亚型，以急性或亚急性认知障碍、面–臂肌张力障碍发作、癫痫、精神障碍和低钠血症为特征。我们报道了一例抗LGI1抗体相关脑炎合并桥本甲状腺炎的病例。由于自身免疫性脑炎的临床和影像学表现呈多样性，常给诊断带来挑战。在这篇文章中，我们讨论了该类自身免疫性脑炎的相关特征及其他合并疾病，提高神经科医生对该类自身免疫性脑炎的认识，对早期诊断、治疗甚至预后都具有重要意义。
Abstract: Autoimmune encephalitis is a rare neuroinflammatory disease, and since the first report of N- Me-thyl-D-Aspartate (NMDA) antibody encephalitis in 2005, a remarkable number of novel pathogenic antibodies have been described. Autoimmune encephalitis can be categorized into different types based on the specific antibodies involved. Anti-Leucine-Rich Glioma-Inactivated 1 (LGI1) anti-body-associated encephalitis is a subtype of autoimmune encephalitis characterized by acute or subacute cognitive impairment, faciobrachial dystonic seizures, seizures, psychiatric disturbances, and hyponatremia. In this case report, we present a case of anti-LGI1 antibody-associated encepha-litis coexisting with Hashimoto’s thyroiditis. Due to the diverse clinical and radiological presenta-tions of autoimmune encephalitis, diagnosis can be challenging. In this article, we discuss the dis-tinctive features of this subtype of autoimmune encephalitis and its comorbidities. Raising aware-ness among neurologists about this type of autoimmune encephalitis is crucial for early diagnosis, treatment, and prognosis.
文章引用：刘悦, 李翠萍, 田新涛, 张晓蒙, 杨绍楠. 抗LGI1抗体相关脑炎一例病例报道并文献复习[J]. 临床医学进展, 2023, 13(10): 16177-16184. https://doi.org/10.12677/ACM.2023.13102262

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