冠心病患者血清TLR4水平增高及其与TLR4基因突变和临床的关系的研究

Study on the Relationship between the Increased Serum TLR4 Level and TLR4 Gene Mutation and Clinic in Patients with Coronary Heart Disease

摘要: 目的：探讨冠心病患者血清TLR4水平增高及其与TLR4基因突变和临床的关系。方法：选取PCI术的冠心病患者286例，检测血清TLR4水平，将TLR4 ≥ 3.50 ng/ml列入高水平组，<3.5 ng/ml列入低水平组，比较两组患者的体质指数(BMI)、血压、血脂、血糖、血尿酸、C反应蛋白(CRP)、β2微球蛋白(β2MG)、白细胞介素6 (IL6)和toll样受体4 (TLR4)基因rs4986790、rs4986791位点碱基水平。结果：血清TLR4高水平组TLR4基因突变率高于低水平组，TLR4高水平组患者BMI、收缩压、总胆固醇、甘油三酯、空腹血糖、血尿酸、β2MG、CRP、IL6水平高于低水平组(P < 0.01或P < 0.05)。结论：血清TLR4水平增高的冠心病患者其TLR4基因突变率高，代谢紊乱，炎症因子活跃。

Abstract: Objective: To investigate the relationship between the increased level of serum TLR4 and TLR4 gene mutation in patients with coronary heart disease (CHD). Methods: Serum TLR4 levels were measured in 286 patients with coronary heart disease undergoing PCI. Patients with TLR4 ≥ 3.50 ng/ml were classified as a high-level group, and those with TLR4 ≥ 3.5 ng/ml were classified as low level group, body mass index (BMI), blood pressure, blood lipids, blood glucose, serum uric acid, c-reactive protein (CRP), β2 microglobulin (β2 MG), interleukin 6 (IL6) and RS4986790, RS4986791 of toll-like receptor 4 (TLR4) gene were compared between the two groups. Results: The mutation rate of the TLR4 gene in the high-level group was higher than that in the low-level group, the levels of BMI, systolic blood pressure, total cholesterol, triglyceride, fasting blood glucose, serum uric acid, β2 mg, CRP and IL-6 were higher in the high TLR4 group than in the low TLR4 group (P & Lt; 0.01 or P & Lt; 0.05). Conclusion: Patients with high serum TLR4 levels have a high mutation rate of the TLR4 gene, metabolic disorder and active inflammatory factors.