小胶质细胞的双重作用在神经系统疾病中的研究进展
Research Progress on the Dual Role of Microglia in Neurological Diseases
DOI: 10.12677/ACM.2023.13102295, PDF,    国家自然科学基金支持
作者: 赵 璐, 杨光路*, 贾凯茹, 杨晓帆, 潘 浩：内蒙古医科大学附属医院，内蒙古 呼和浩特
关键词: 抑郁症；小胶质细胞；阿尔兹海默症；脑胶质瘤；多发性硬化症；Depression Disorder； Microglia； Alzheimer’s Disease； Glioma of the Brain； Multiple Sclerosis
摘要: 中枢神经系统(CNS)的免疫系统主要由先天免疫细胞组成。这些是高度特化的巨噬细胞，要么存在于实质(称为小胶质细胞MG)中，要么存在于软脑膜、血管周围和脉络丛巨噬细胞。虽然它们主要被认为是吞噬细胞，但它们的功能远远超出了在发育和疾病过程中简单地去除细胞碎片。近年来小胶质细胞在中枢神经系统疾病中发挥的损伤及保护的双重作用的研究越来越受到重视，本文通过对小胶质细胞正常功能及在常见中枢神经系统疾病中的作用进行综述，以寻求更好的临床治疗新思路和新方向。
Abstract: The immune system of the central nervous system (CNS) is mainly composed of innate immune cells. These are highly specialized macrophages that either exist in the parenchyma (referred to as microglia MG) or in the pia mater, perivascular, and choroidal plexus macrophages. Although they are primarily considered phagocytes, their function goes far beyond simply removing cell fragments during development and disease processes. In recent years, research on the dual roles of microglia in the damage and protection of central nervous system diseases has received increasing attention. This article reviews the normal function of microglia and their role in common central nervous sys-tem diseases, in order to seek better clinical treatment ideas and new directions.
文章引用：赵璐, 杨光路, 贾凯茹, 杨晓帆, 潘浩. 小胶质细胞的双重作用在神经系统疾病中的研究进展[J]. 临床医学进展, 2023, 13(10): 16401-16405. https://doi.org/10.12677/ACM.2023.13102295

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