凝血功能与泌尿系肿瘤的研究进展
Advances in the Study of Coagulation Function and Urologic Tumors
DOI: 10.12677/ACM.2023.13102296, PDF,   
作者: 黄 海:青海大学研究生院,青海 西宁;任海林*:青海大学附属医院泌尿外科,青海 西宁
关键词: 泌尿系肿瘤凝血功能预后Urinary Tumor Coagulation Function Prognosis
摘要: 随着泌尿系肿瘤的发病率不断增高,肿瘤的高凝状态也越来越明显,高凝和纤溶亢进的风险也越来越高,常是早期的临床表现之一。随着肿瘤的进展,血栓风险增加,对患者的预后产生影响,因此,明确凝血功能的变化对抗凝或止血药物的使用至关重要,同时凝血功能等变化对评估患者预后也具有一定价值。
Abstract: With the increasing incidence of urologic tumors, the hypercoagulable state of tumors is becoming more pronounced, and the risk of hypercoagulation and hyperfibrinolysis, often one of the early clinical manifestations, is increasing. As the tumor progresses, the risk of thrombosis increases, which has an impact on the patient’s prognosis. Therefore, it is crucial to clarify the changes in co-agulation function for the use of anticoagulant or hemostatic drugs, and also changes in coagulation function and other changes are of value in evaluating the patient’s prognosis.
文章引用:黄海, 任海林. 凝血功能与泌尿系肿瘤的研究进展[J]. 临床医学进展, 2023, 13(10): 16406-16411. https://doi.org/10.12677/ACM.2023.13102296

参考文献

[1] Ellinger, J., Müller, S.C. and Dietrich, D. (2015) Epigenetic Biomarkers in the Blood of Patients with Urological Malig-nancies. Expert Review of Molecular Diagnostics, 15, 505-516. [Google Scholar] [CrossRef] [PubMed]
[2] Zheng, R., Zhang, S., Zeng, H., et al. (2022) Cancer Inci-dence and Mortality in China, 2016. Journal of the National Cancer Center, 2, 1-9. [Google Scholar] [CrossRef] [PubMed]
[3] 董德鑫, 李汉忠, 纪志刚, 等. 常见泌尿生殖系统肿瘤的病因学分析及预防[J]. 基础医学与临床, 2019, 39(6): 904-907. [Google Scholar] [CrossRef
[4] 胡永伟, 白永颖, 张靖华. 乳腺癌患者血浆凝血参数的变化及临床意义[J]. 医学信息, 2023, 36(4): 113-117.
[5] Tikhomirova, I., Petrochenko, E., Malysheva, Y., et al. (2016) Interrelation of Blood Coagulation and Hemorheology in Cancer. Clinical Hemorheology and Microcirculation, 64, 635-644. [Google Scholar] [CrossRef
[6] 周合冰, 刘复强, 闫树旭, 等. 恶性疾病患者凝血纤溶分子标志物的研究[J]. 中国卫生检验杂志, 2008(2): 302-305.
[7] Tas, F., Kilic, L., Serilmez, M., et al. (2013) Clinical and Prognostic Significance of Coagulation Assays in Lung Cancer. Respiratory Medicine, 107, 451-457. [Google Scholar] [CrossRef] [PubMed]
[8] Khorana, A.A., Mackman, N., Falanga, A., et al. (2022) Can-cer-Associated Venous Thromboembolism. Nature Reviews. Disease Primers, 8, Article No. 11. [Google Scholar] [CrossRef] [PubMed]
[9] Kacimi, S.E.O., Moeinafshar, A., Haghighi, S.S., et al. (2022) Venous Thromboembolism in Cancer and Cancer Immunotherapy. Critical Reviews in Oncology/Hematology, 178, Arti-cle ID: 103782. [Google Scholar] [CrossRef] [PubMed]
[10] Izuegbuna, O.O., Agodirin, O.S., Olawumi, H.O., et al. (2021) Plasma D-Dimer and Fibrinogen Levels Correlates with Tumor Size and Disease Progression in Nigerian Breast Cancer Patients. Cancer Investigation, 39, 597-606. [Google Scholar] [CrossRef] [PubMed]
[11] Zhang, L., Ye, J., Luo, Q., et al. (2020) Prediction of Poor Outcomes in Patients with Colorectal Cancer: Elevated Preoperative Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT). Cancer Management and Research, 12, 5373-5384. [Google Scholar] [CrossRef
[12] 石磊, 孟桂芳. 凝血四项指标与肺癌患者临床分期的相关性[J]. 航空航天医学杂志, 2023, 34(2): 163-166.
[13] 王瑜, 王珊珊. 肿瘤标志物及凝血功能检测对宫颈癌分期诊断价值探讨[J]. 社区医学杂志, 2023, 21(3): 146-150. [Google Scholar] [CrossRef
[14] Ahlbrecht, J., Dickmann, B., Ay, C., et al. (2012) Tumor Grade Is Associated with Venous Thromboembolism in Patients with Cancer: Results from the Vienna Cancer and Thrombosis Study. Journal of Clinical Oncology, 30, 3870-3875. [Google Scholar] [CrossRef
[15] Falanga, A., Schieppati, F. and Russo, D. (2015) Cancer Tissue Procoagulant Mechanisms and the Hypercoagulable State of Patients with Cancer. Seminars in Thrombosis and Hemo-stasis, 41, 756-764. [Google Scholar] [CrossRef] [PubMed]
[16] Falanga, A., Russo, L., Milesi, V., et al. (2017) Mechanisms and Risk Factors of Thrombosis in Cancer. Critical Reviews in Oncology/Hematology, 118, 79-83. [Google Scholar] [CrossRef] [PubMed]
[17] Berny-Lang, M.A., Aslan, J.E., Tormoen, G.W., et al. (2011) Promotion of Experimental Thrombus Formation by the Procoagulant Activity of Breast Cancer Cells. Physical Biology, 8, Article ID: 015014. [Google Scholar] [CrossRef] [PubMed]
[18] Hong, S.K., Ko, D.W., Park, J., et al. (2010) Alteration of An-tithrombin III and D-Dimer Levels in Clinically Localized Prostate Cancer. Korean Journal of Urology, 51, 25-29. [Google Scholar] [CrossRef] [PubMed]
[19] Chen, X., Ji, H., Wang, J., et al. (2020) Prognostic Value of the Preoperative Plasma D-Dimer Levels in Patients with Upper Tract Urothelial Carcinoma in a Retrospective Cohort Study. OncoTargets and Therapy, 13, 5047-5055. [Google Scholar] [CrossRef
[20] Çalişkan, S. and Sungur, M. (2017) Fibrinogen and D-Dimer Levels in Prostate Cancer: Preliminary Results. Prostate International, 5, 110-112. [Google Scholar] [CrossRef] [PubMed]
[21] Polterauer, S., Seebacher, V., Hefler-Frischmuth, K., et al. (2009) Fibrinogen Plasma Levels Are an Independent Prognostic Parameter in Patients with Cervical Cancer. American Journal of Obstetrics and Gynecology, 200, 647.e1-7. [Google Scholar] [CrossRef] [PubMed]
[22] Sheng, L., Luo, M., Sun, X., et al. (2013) Serum Fibrinogen Is an Independent Prognostic Factor in Operable Nonsmall Cell Lung Cancer. International Journal of Cancer, 133, 2720-2725. [Google Scholar] [CrossRef] [PubMed]
[23] Wang, F.M. and Xing, N.Z. (2021) Systemic Coagulation Markers Especially Fibrinogen Are Closely Associated with the Aggressiveness of Prostate Cancer in Patients Who Un-derwent Transrectal Ultrasound-Guided Prostate Biopsy. Disease Markers, 2021, Article ID: 8899994. [Google Scholar] [CrossRef] [PubMed]
[24] Liu, R., Zhou, X., Zou, L., et al. (2019) Clinicopathological and Prog-nostic Significance of Preoperative Plasma Fibrinogen Level in Patients with Upper Urinary Tract Urothelial Carcinoma: A Retrospective Tumor Marker Prognostic Study. International Journal of Surgery, 65, 88-93. [Google Scholar] [CrossRef] [PubMed]
[25] Sasaki, T. and Onishi, T. (2015) Pretherapeutic Plasma Fibrinogen Level Is an Independent Survival Predictor in Renal Cell Carcinoma. Oncology Research and Treatment, 38, 374-378. [Google Scholar] [CrossRef] [PubMed]
[26] Yang, S., Guan, H., Wang, S., et al. (2020) Plasma Fibrinogen Predicts the Prognosis of Bladder Cancer Patients after Radical Cystectomy. Cancer Management and Research, 12, 9303-9314. [Google Scholar] [CrossRef
[27] Gay, L.J. and Felding-Habermann, B. (2011) Contribution of Plate-lets to Tumour Metastasis. Nature Reviews Cancer, 11, 123-134. [Google Scholar] [CrossRef] [PubMed]
[28] Bambace, N.M. and Holmes, C.E. (2011) The Platelet Contribution to Cancer Progression. Journal of Thrombosis and Haemosta-sis: JTH, 9, 237-249. [Google Scholar] [CrossRef] [PubMed]
[29] Ishikawa, S., Miyashita, T., Inokuchi, M., et al. (2016) Platelets Surrounding Primary Tumor Cells Are Related to Chemoresistance. Oncology Reports, 36, 787-794. [Google Scholar] [CrossRef] [PubMed]
[30] Shimodaira, K., Nakashima, J., Nakagami, Y., et al. (2020) Prognostic Value of Platelet Counts in Patients with Metastatic Prostate Cancer Treated with Endocrine Therapy. Urology Journal, 17, 36-41.
[31] Moschini, M., Suardi, N., Pellucchi, F., et al. (2014) Impact of Preoperative Thrombocytosis on Pathological Outcomes and Survival in Patients Treated with Radical Cystectomy for Bladder Carcinoma. Anticancer Research, 34, 3225-3230.
[32] Ha, Y.S., Chung, J.W., Chun, S.Y., et al. (2017) Impact of Preoperative Thrombocytosis on Prognosis after Surgical Treatment in Pathological T1 and T2 Renal Cell Carcinoma: Results of a Multi-Institutional Comprehensive Study. Oncotarget, 8, 64449-64458. [Google Scholar] [CrossRef] [PubMed]
[33] Smith, C.J., Dorsey, T.H., Tang, W., et al. (2017) Aspirin Use Reduces the Risk of Aggressive Prostate Cancer and Disease Recur-rence in African-American Men. Cancer Epidemiology, Biomarkers & Prevention, 26, 845-853. [Google Scholar] [CrossRef
[34] Dell’Atti, L. (2014) Correlation between Prolonged Use of Aspirin and Prognostic Risk in Prostate Cancer. Tumori, 100, 486-490. [Google Scholar] [CrossRef] [PubMed]
[35] Pastore, A.L., Palleschi, G., Fuschi, A., et al. (2015) Can Daily Intake of Aspirin and/or Statins Influence the Behavior of Non-Muscle Invasive Bladder Cancer? A Retrospective Study on a Co-hort of Patients Undergoing Transurethral Bladder Resection. BMC Cancer, 15, Article No. 120. [Google Scholar] [CrossRef] [PubMed]
[36] Park, J.C., Pratz, C.F., Tesfaye, A., et al. (2015) The Effect of Therapeutic Anticoagulation on Overall Survival in Men Receiving First-Line Docetaxel Chemotherapy for Metastatic Castration-Resistant Prostate Cancer. Clinical Genitourinary Cancer, 13, 32-38. [Google Scholar] [CrossRef] [PubMed]