迷走神经刺激在改善缺血性脑卒中后功能障碍中的应用
Vagus Nerve Stimulation in Improving Dysfunction after Ischemic Stroke
DOI: 10.12677/ACM.2023.13102311, PDF,    科研立项经费支持
作者: 李 鑫*, 廖金成, 王 怡, 康富丽, 蔡青青:重庆医科大学,重庆;中国科学院重庆绿色智能技术研究院,重庆;中国科学院大学重庆学院,重庆;重庆市人民医院神经内科,重庆;张晖集:重庆医科大学,重庆;薛锐灵:重庆医科大学,重庆;中国科学院重庆绿色智能技术研究院,重庆;中国科学院大学重庆学院,重庆;重庆市人民医院康复医学科,重庆;马璟曦#:重庆医科大学,重庆;重庆市人民医院神经内科,重庆
关键词: 迷走神经刺激缺血性脑卒中Vagus Nerve Stimulation Ischemic Stroke
摘要: 缺血性脑卒中在世界范围内是非常严重的社会健康问题,不仅严重降低患者的生活质量,而且也会给社会造成巨大经济压力。标准的卒中治疗不能满足卒中后功能改善的需求,因此我们需要提出更多治疗方法。目前,迷走神经刺激已经被批准应用于癫痫、抑郁、偏头痛等领域,并且有大量基础以及临床研究证实其在改善卒中后功能障碍方面有积极作用。在这篇综述中,我们首先探讨了迷走神经刺激对于脑卒中功能障碍改善可能存在的潜在机制,其次详细讲述了迷走神经刺激对于脑卒中后运动、感觉、认知、情绪、吞咽功能障碍改善的应用现状,最后探讨了迷走神经刺激在临床应用所要面临的挑战。迷走神经刺激在缺血性脑卒中里的应用研究进入了关键阶段,我们仍需更多努力将该技术转向临床。
Abstract: Ischemic stroke is a very serious social health problem worldwide, which not only seriously reduces the quality of life of patients but also causes great economic pressure on society. Standard stroke treatments cannot fulfill the need for functional improvement after stroke, so we need to propose more therapeutic approaches. Currently, vagus nerve stimulation has been approved for use in epi-lepsy, depression, and migraine, and a large number of basic experimental as well as clinical studies have demonstrated its positive effects in improving post-stroke dysfunction. In this review, we firstly discuss the potential mechanisms of vagus nerve stimulation for the improvement of post-stroke dysfunction, then detail the current status of vagus nerve stimulation for the improve-ment of post-stroke motor, sensory, cognitive, emotional, and swallowing dysfunction, and finally discuss the challenges of vagus nerve stimulation in clinical applications. The study of vagus nerve stimulation in ischemic stroke has entered a critical stage, and more efforts are needed to transfer this technique to the clinical setting.
文章引用:李鑫, 廖金成, 张晖集, 薛锐灵, 王怡, 康富丽, 蔡青青, 马璟曦. 迷走神经刺激在改善缺血性脑卒中后功能障碍中的应用[J]. 临床医学进展, 2023, 13(10): 16512-16524. https://doi.org/10.12677/ACM.2023.13102311

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