子宫自然杀伤细胞及其与妊娠并发症关系的研究进展
Advances in the Study of Uterine Natural Killer Cells and Their Relationship with Pregnancy Complications
DOI: 10.12677/ACM.2023.13102315, PDF,   
作者: 杨春燕：黑龙江中医药大学研究生院，黑龙江 哈尔滨
关键词: 妊娠；子宫自然杀伤细胞；复发性流产；子痫前期；Pregnancy； Uterine Natural Killer Cells； Recurrent Abortion； Preeclampsia
摘要: 子宫自然杀伤细胞(uterine natural killer cells, uNK)作为先天免疫系统的一员，约占妊娠期淋巴细胞总数的70%，在对宿主免受病原体侵袭方面起着重要作用，并参与了一系列影响妊娠成功的生理过程。能通过分泌多种细胞因子，促进滋养层侵袭，重塑螺旋动脉，保护胎儿发育，维持正常妊娠。而失衡的uNK细胞会导致螺旋动脉重构不足和滋养层入侵受损，并与产科并发症如子痫前期、复发性流产、胎儿生长受限密切相关。本篇综述对uNK细胞及其uNK细胞在生理或病理条件下对妊娠的作用进行了介绍，为未来靶向妊娠相关并发症的治疗提供新的线索。
Abstract: Uterine natural killer cells (uNK), as a member of the innate immune system, account for about 70% of the total number of lymphocytes during pregnancy, play an important role in protecting the host from pathogens, and participate in a series of physiological processes that affect the success of pregnancy. It can promote trophoblast invasion, reshape spiral artery, protect fetal development, and maintain normal pregnancy by secreting a variety of cytokines. Unbalanced uNK cells can lead to inadequate spiral artery remodeling and impaired trophoblast invasion, and are closely associ-ated with obstetric complications such as preeclampsia, recurrent abortion, and fetal growth re-striction. This review introduces the role of uNK cells and uNK cells in pregnancy under physiologi-cal or pathological conditions and provides new clues for future therapies targeting pregnan-cy-related complications.
文章引用：杨春燕. 子宫自然杀伤细胞及其与妊娠并发症关系的研究进展[J]. 临床医学进展, 2023, 13(10): 16543-16550. https://doi.org/10.12677/ACM.2023.13102315

参考文献

[1] 张维平, 王文文, 张调平, 等. 主动免疫治疗对原因不明性复发性流产患者Treg/Th17免疫平衡的影响[J]. 中国妇产科临床杂志, 2021, 22(3): 249-251.
[2] Mahajan, D., Sharma, N.R., Kancharla, S., et al. (2022) Role of Natural Killer Cells during Pregnancy and Related Complications. Biomolecules, 12, Article 68. [Google Scholar] [CrossRef] [PubMed]
[3] Yang, F., Zheng, Q. and Jin, L. (2019) Dynamic Function and Com-position Changes of Immune Cells during Normal and Pathological Pregnancy at the Maternal-Fetal Interface. Frontiers in Immunology, 10, Article No. 2317. [Google Scholar] [CrossRef] [PubMed]
[4] Arachchige, A.S.P.M. (2021) Human NK Cells: From Develop-ment to Effector Functions. Innate Immunity, 27, 212-229. [Google Scholar] [CrossRef] [PubMed]
[5] Filipovic, I., Chiossone, L., Vacca, P., et al. (2018) Molecular Definition of Group 1 Innate Lymphoid Cells in the Mouse Uterus. Nature Communications, 9, Article No. 4492. [Google Scholar] [CrossRef] [PubMed]
[6] Huhn, O., Ivarsson, M.A., Gardner, L., et al. (2020) Distinctive Phenotypes and Functions of Innate Lymphoid Cells in Human Decidua during Early Pregnancy. Nature Communica-tions, 11, Article No. 381. [Google Scholar] [CrossRef] [PubMed]
[7] Fu, Y.Y., Ren, C.E., Qiao, P.Y, et al. (2021) Uterine Natural Killer Cells and Recurrent Spontaneous Abortion. American Journal of Reproductive Immunology, 86, e13433. [Google Scholar] [CrossRef] [PubMed]
[8] Jin, F.F., Liu, W., Cheng, G., Cai, S.C., Yin, T.L. and Diao L.H. (2023) The Function of Decidua Natural Killer Cells in Physiology and Pathology of Pregnancy. American Journal of Reproductive Immunology, 90, e13755. [Google Scholar] [CrossRef] [PubMed]
[9] 单亚莉, 倪鑫. 母胎界面自然杀伤细胞的研究进展[J]. 生理学报, 2021, 73(1): 103-114.
[10] Sojka, D.K., Yang, L., Plougastel-Douglas, B., et al. (2018) Cutting Edge: Local Proliferation of Uterine Tissue-Resident NK Cells during Decidualization in Mice. The Journal of Immunology, 201, 2551-2556. [Google Scholar] [CrossRef] [PubMed]
[11] Zhao, H., Bo, C., Kang, Y., et al. (2017) What Else Can CD39 Tell Us? Frontiers in Immunology, 8, 727. [Google Scholar] [CrossRef] [PubMed]
[12] 马蓉, 陈书强, 王晓红. 子宫NK细胞的异质性及其功能研究进展[J]. 细胞与分子免疫学杂志, 2022, 38(7): 657-660.
[13] Vento-Tormo, R., Efremova, M., Botting, R.A., et al. (2018) Single-Cell Reconstruction of the Early Maternal-Fetal Interface in Humans. Nature, 563, 347-353. [Google Scholar] [CrossRef] [PubMed]
[14] Schuster, I.S., Sng, X.Y.X., Lau, C.M., et al. (2023) Infection Induces Tissue-Resident Memory NK Cells That Safeguard Tissue Health. Immunity, 56, 531-546, e6. [Google Scholar] [CrossRef] [PubMed]
[15] Goldman-Wohl, D., Gamliel, M., Mandelboim, O., et al. (2019) Learning from Experience: Cellular and Molecular Bases for Improved Outcome in Subsequent Pregnancies. American Journal of Obstetrics and Gynecology, 221, 183-193. [Google Scholar] [CrossRef] [PubMed]
[16] Fraser, R. and Zenclussen, A.C. (2022) Killer Timing: The Temporal Uterine Natural Killer Cell Differentiation Pathway and Impli-cations for Female Reproductive Health. Frontiers in Endocrinology, 13, Article ID: 904744. [Google Scholar] [CrossRef] [PubMed]
[17] Zhang, X. and Wei, H. (2021) Role of Decidual Natural Killer Cells in Human Pregnancy and Related Pregnancy Complications. Frontiers in Immunology, 12, Article ID: 728291. [Google Scholar] [CrossRef] [PubMed]
[18] Fu, B., Zhou, Y., Ni, X., et al. (2017) Natural Killer Cells Pro-mote Fetal Development through the Secretion of Growth-Promoting Factors. Immunity, 47, 1100-1113, e6. [Google Scholar] [CrossRef] [PubMed]
[19] Zhou, Y., Fu, B., Xu, X., et al. (2020) PBX1 Expression in Uterine Natural Killer Cells Drives Fetal Growth. Science Translational Medicine, 12, eaax1798. [Google Scholar] [CrossRef] [PubMed]
[20] Xie, M., Li, Y., Meng, Y.Z., et al. (2022) Uterine Natural Killer Cells: A Rising Star in Human Pregnancy Regulation. Frontiers in Immunology, 13, Article ID: 918550. [Google Scholar] [CrossRef] [PubMed]
[21] Chen, Y., Lu, D., Churov, A., et al. (2020) Research Progress on NK Cell Receptors and Their Signaling Pathways. Mediators Inflammation, 2020, Article ID: 6437057. [Google Scholar] [CrossRef] [PubMed]
[22] Jabrane-Ferrat, N. (2019) Features of Human Decidual NK Cells in Healthy Pregnancy and During Viral Infection. Frontiers in Immunology, 10, Article 1397. [Google Scholar] [CrossRef] [PubMed]
[23] Alexandrova, M., Manchorova, D. and Dimova, T. (2022) Immun-ity at Maternal-Fetal Interface: KIR/HLA (Allo) Recognition. Immunological Reviews, 308, 55-76. [Google Scholar] [CrossRef] [PubMed]
[24] Abbas, Y., Turco, M.Y., Burton, G.J., et al. (2020) Investigation of Human Trophoblast Invasion in Vitro. Human Reproduction Update, 26, 501-513. [Google Scholar] [CrossRef] [PubMed]
[25] Sfakianoudis, K., Rapani, A., Grigoriadis, S., et al. (2021) The Role of Uterine Natural Killer Cells on Recurrent Miscarriage and Recurrent Implantation Failure: From Pathophysiology to Treatment. Biomedicines, 9, Article 1425. [Google Scholar] [CrossRef] [PubMed]
[26] Alecsandru, D., Barrio, A., Garrido, N., et al. (2020) Parental Human Leukocyte Antigen-C Allotypes Are Predictive of Live Birth Rate and Risk of Poor Placentation in Assisted Re-productive Treatment. Fertility and Sterility, 114, 809-817. [Google Scholar] [CrossRef] [PubMed]
[27] Yang, X., Yang, Y., Yuan, Y., et al. (2020) The Roles of Uterine Natural Killer (NK) Cells and KIR/HLA-C Combination in the Development of Preeclampsia: A Systematic Re-view. BioMed Research International, 2020, Article ID: 4808072. [Google Scholar] [CrossRef] [PubMed]
[28] Du, M., Wang, W., Huang, L., et al. (2022) Natural Killer Cells in the Pathogenesis of Preeclampsia: A Double-Edged Sword. The Journal of Maternal-Fetal & Neonatal Medicine, 35, 1028-1035. [Google Scholar] [CrossRef] [PubMed]
[29] Zhang, J., Dunk, C.E., Shynlova, O., et al. (2019) TGFb1 Suppresses the Activation of Distinct dNK Subpopulations in Preeclampsia. EBioMedicine, 39, 531-539. [Google Scholar] [CrossRef] [PubMed]
[30] Kanter, J.R., Mani, S., Gordon, S.M., et al. (2021) Uterine Natu-ral Killer Cell Biology and Role in Early Pregnancy Establishment and Outcomes. F&S Reviews, 2, 265-286. [Google Scholar] [CrossRef] [PubMed]
[31] Qiu, J., Du, T., Li, W., et al. (2023) Impact of Recurrent Pregnancy Loss History on Reproductive Outcomes in Women Undergoing Fertility Treatment. American Journal of Obstetrics and Gynecology, 228, e1-66, e9. [Google Scholar] [CrossRef] [PubMed]
[32] Giuliani, E., Parkin, K.L., Lessey, B.A., et al. (2014) Characteriza-tion of Uterine NK Cells in Women with Infertility or Recurrent Pregnancy Loss and Associated Endometriosis. Ameri-can Journal of Reproductive Immunology 72, 262-269. [Google Scholar] [CrossRef] [PubMed]
[33] Fonseca, B.M., Cunha, S.C., Gonçalves, D., et al. (2020) Decidual NK Cell-Derived Conditioned Medium from Miscarriages Affects Endometrial Stromal Cell Decidualisation: Endocannabinoid Anandamide and Tumour Necrosis Factor-α Crosstalk. Hu-man Reproduction, 35, 265-274. [Google Scholar] [CrossRef] [PubMed]
[34] Díaz-Hernández, I., Alecsandru, D., García-Velasco, J.A., et al. (2021) Uterine Natural Killer Cells: From Foe to Friend in Reproduction. Human Reproduc-tion Update, 27, 720-746. [Google Scholar] [CrossRef] [PubMed]
[35] Guo, W., Fang, L., Li, B., et al. (2017) Decreased Human Leukocyte Antigen-G Expression by miR-133a Contributes to Impairment of Proinvasion and Proan-giogenesis Functions of Decidual NK Cells. Frontiers in Immunology, 8, Article 741. [Google Scholar] [CrossRef] [PubMed]
[36] Andreescu, M., Frîncu, F., Plotogea, M., et al. (2023) Recurrent Abortion and the Involvement of Killer-Cell Immunoglobulin-Like Receptor (KIR) Genes, Activated T Cells, NK Ab-normalities, and Cytokine Profiles. Journal of Clinical Medicine, 12, Article 1355. [Google Scholar] [CrossRef] [PubMed]
[37] Di, X., Duan, Z., Ma, Y., Song, X., Hao, Y., Li, G., Tan, Z., Lou, Y. and Lin, X. (2024) Jiawei Shoutai Pill Promotes Decidualization by Regulating the SGK1/ENaC Pathway in Recurrent Spontaneous Abortion. Journal of Ethnopharmacology, 318, Article ID: 116939. [Google Scholar] [CrossRef] [PubMed]

为你推荐