癫痫相关认知功能障碍的研究
Study of Epilepsy-Related Cognitive Dysfunction
DOI: 10.12677/ACM.2023.13102326, PDF,    科研立项经费支持
作者: 段静静, 常一凡, 罕迦尔别克·库琨, 贾文霄*：新疆医科大学第一附属医院影像中心，新疆 乌鲁木齐
关键词: 癫痫；认知功能障碍；Epilepsy； Cognitive Dysfunction
摘要: 癫痫患者经常会发生认知功能障碍。大多数认知问题受到各种相互关联的因素的影响，包括癫痫的早期发作和癫痫发作的频率、强度和持续时间以及抗癫痫药物治疗。成人癫痫患者的大多数认知问题包括记忆力、注意力和执行功能缺陷。然而，哪个认知区域受损很大程度上取决于癫痫活动的位置。此外，信号通路和神经元网络的改变在导致认知障碍的机制中都起着至关重要的作用。同时，研究表明，抗癫痫药物(AEDs)的联合使用会增加认知障碍的风险。然而区分每个因素的贡献可能具有挑战性，因为它们通常紧密交织在一起。因此，本文中我们主要探讨癫痫认知功能的因素，重点从癫痫认知功能的发生机制及不同因素对癫痫认知功能的影响2个方面展开讨论。
Abstract: Cognitive dysfunction frequently occurs in patients with epilepsy. Most cognitive problems are in-fluenced by a variety of interrelated factors, including the early onset of seizures and the frequency, intensity, and duration of seizures, as well as antiepileptic drug therapy. Most cognitive problems in adults with epilepsy include deficits in memory, attention, and executive function. However, which cognitive region is impaired depends largely on the location of epileptic activity. In addition, altera-tions in both signaling pathways and neuronal networks play a crucial role in the mechanisms leading to cognitive impairment. At the same time, studies have shown that the combination of an-tiepileptic drugs (AEDs) increases the risk of cognitive impairment. Yet distinguishing the contri-bution of each factor can be challenging, as they are often tightly intertwined. Therefore, in this ar-ticle, we focus on the factors of cognitive function in epilepsy, focusing on 2 aspects: the mechanisms of epileptic cognitive function and the effects of different factors on epileptic cognitive function.
文章引用：段静静, 常一凡, 罕迦尔别克·库琨, 贾文霄. 癫痫相关认知功能障碍的研究[J]. 临床医学进展, 2023, 13(10): 16616-16622. https://doi.org/10.12677/ACM.2023.13102326

参考文献

[1] Lenck-Santini, P.-P. and Scott, R.C. (2015) Mechanisms Responsible for Cognitive Impairment in Epilepsy. Cold Spring Harbor Perspectives in Medicine, 5, a022772. [Google Scholar] [CrossRef] [PubMed]
[2] Liu, B., Kou, J.Y., Li, F.Y., Huo, D. and Xu, J.R. (2020) Lemon Essential Oil Ameliorates Age-Associated Cognitive Dysfunction via Modulating Hippocampal Synaptic Density and Inhibiting Acetylcholinesterase. Aging, 12, 8622-8639. [Google Scholar] [CrossRef] [PubMed]
[3] Bell, B., Lin, J.J., Seidenberg, M. and Hermann, B. (2011) The Neuro-biology of Cognitive Disorders in Temporal Lobe Epilepsy. Nature Reviews Neurology, 7, 154-164. [Google Scholar] [CrossRef] [PubMed]
[4] Lin, H., Holmes, G.L., Kubie, J.L. and Muller, R.U. (2009) Recurrent Seizures Induce a Reversible Impairment in a Spatial Hidden Goal Task. Hippocampus, 19, 817-827. [Google Scholar] [CrossRef] [PubMed]
[5] Nickels, K.C. and Wirrell, E.C. (2017) Cognitive and Social Outcomes of Epileptic Encephalopathies. Seminars in Pediatric Neurology, 24, 264-275. [Google Scholar] [CrossRef] [PubMed]
[6] Yu, F.H., Mantegazza, M., Westenbroek, R.E., Robbins, C.A. and Kalume, F. (2006) Reduced Sodium Current in GABAergic Interneurons in a Mouse Model of Severe Myoclonic Epi-lepsy in Infancy. Nature Neuroscience, 9, 1142- 1149. [Google Scholar] [CrossRef] [PubMed]
[7] Macdonald, R.L., Kang, J.-Q. and Gallagher, M.J. (2010) Mutations in GABAA Receptor Subunits Associated with Genetic Epilepsies. The Journal of Physiology, 588, 1861-1869. [Google Scholar] [CrossRef] [PubMed]
[8] Bateup, H.S., Takasaki, K.T., Saulnier, J.L., Denefrio, C.L. and Sabatini, B.L. (2011) Loss of Tsc1 in Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function. The Journal of Neuroscience: The Official Journal of the Society for Neuro-science, 31, 8862-8869. [Google Scholar] [CrossRef] 
[9] Quraishi, I.H., Stern, S., Mangan, K.P., Zhang, Y.L. and Ali, S.R. (2019) An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack K Currents. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 39, 7438-7449. [Google Scholar] [CrossRef] 
[10] Staley, K. (2015) Molecular Mechanisms of Epilepsy. Nature Neuroscience, 18, 367-372. [Google Scholar] [CrossRef] [PubMed]
[11] Holmes, G.L. (2015) Cognitive Impairment in Epilepsy: The Role of Network Abnormalities. Epileptic Disorders: International Epilepsy Journal with Videotape, 17, 101-116. [Google Scholar] [CrossRef] [PubMed]
[12] Landi, S., Petrucco, L., Sicca, F. and Ratto, G.M. (2019) Transient Cognitive Impairment in Epilepsy. Frontiers in Molecular Neuroscience, 11, Article No. 458. [Google Scholar] [CrossRef] [PubMed]
[13] Zhou, J.-L., Shatskikh, T.N., Liu, X.Z. and Holmes, G.L. (2007) Impaired Single Cell Firing and Long-Term Potentiation Parallels Memory Impairment Following Recurrent Seizures. The European Journal of Neuroscience, 25, 3667- 3677. [Google Scholar] [CrossRef] [PubMed]
[14] Han, T., Qin, Y.Y., Mou, C.Z., Wang, M. and Jiang, M. (2016) Seizure Induced Synaptic Plasticity Alteration in Hippocampus Is Mediated by IL-1β Receptor through PI3K/Akt Pathway. American Journal of Translational Research, 8, 4499-4509.
[15] Postnikova, T.Y., Zubareva, O.E., Ko-valenko, A.A., Kim, K.K. and Magazanik, L.G. (2017) Status Epilepticus Impairs Synaptic Plasticity in Rat Hippocampus and Is Followed by Changes in Expression of NMDA Receptors. Biochemistry (Moscow), 82, 282-290. [Google Scholar] [CrossRef] 
[16] Cooke, S.F. and Bliss, T.V.P. (2006) Plasticity in the Human Central Nervous System. Brain: A Journal of Neurology, 129, 1659-1673. [Google Scholar] [CrossRef] [PubMed]
[17] Martin, R.C., Griffith, H.R., Faught, E., Gilliam, F. and Mackey, M. (2005) Cognitive Functioning in Community Dwelling Older Adults with Chronic Partial Epilepsy. Epilepsia, 46, 298-303. [Google Scholar] [CrossRef] [PubMed]
[18] Griffith, H.R., Martin, R.C., Bambara, J.K., Marson, D.C. and Faught, E. (2005) Older Adults with Epilepsy Demonstrate Cognitive Impairments Compared with Patients with Amnestic Mild Cognitive Impairment. Epilepsy & Behavior: E&B, 8, 161-168. [Google Scholar] [CrossRef] [PubMed]
[19] Piazzini, A., Canevini, M.P., Turner, K., Chifari, R. and Canger, R. (2006) Elderly People and Epilepsy: Cognitive Function. Epilepsia, 47, 82-84. [Google Scholar] [CrossRef] [PubMed]
[20] 尤华琴, 张延英, 吴俊晓, 等. 吡仑帕奈对癫痫大鼠ERK/CREB/BDNF信号通路及认知功能的影响[J]. 中国老年学杂志, 2022(15): 42.
[21] Gul, A. and Ahmad, H. (2015) Thought Suppression Predicts Task Switching Deficits in Patients with Frontal Lobe Epilepsy. Neurosciences (Riyadh, Saudi Arabia), 20, 153-158. [Google Scholar] [CrossRef] [PubMed]
[22] Wang, L., Wang, L., Chen, S.G., Liu, C.Y. and Lin, W.H. (2019) Factors for Cognitive Impairment in Adult Epileptic Patients. Brain and Be-havior, 10, e01475. [Google Scholar] [CrossRef] [PubMed]
[23] Stafstrom, C.E. and Carmant, L. (2015) Seizures and Epilepsy: An Overview for Neuroscientists. Cold Spring Harbor Perspectives in Medicine, 5, a022426. [Google Scholar] [CrossRef] [PubMed]
[24] Kleen, J.K., Scott, R.C., Holmes, G.L. and Lenck-Santini, P.P. (2010) Hippocampal Interictal Spikes Disrupt Cognition in Rats. Annals of Neurology, 67, 250-257. [Google Scholar] [CrossRef] [PubMed]
[25] Kleen, J.K., Scott, R.C., Holmes, G.L., Roberts, D.W. and Rundle, M.M. (2013) Hippocampal Interictal Epileptiform Activity Disrupts Cognition in Humans. Neurology, 81, 18-24. [Google Scholar] [CrossRef] 
[26] Ung, H., Ung, H., Cazares, C., Nanivadekar, A. and Kini, L. (2017) Interictal Epileptiform Activity outside the Seizure Onset Zone Impacts Cognition. Brain: A Journal of Neurology, 140, 2157-2168. [Google Scholar] [CrossRef] [PubMed]
[27] Hermann, B., Meador, K.J., Gaillard, W.D. and Cramer, J.A. (2010) Cognition across the Lifespan: Antiepileptic Drugs, Epilepsy, or Both? Epilepsy & Behavior: E&B, 17, 1-5. [Google Scholar] [CrossRef] [PubMed]
[28] Eddy, C.M., Rickards, H.E. and Cavanna, A.E. (2011) The Cog-nitive Impact of Antiepileptic Drugs. Therapeutic Advances in Neurological Disorders, 4, 385-407. [Google Scholar] [CrossRef] [PubMed]
[29] Blum, D., Meador, K., Biton, V., Fakhoury, T. and Shneker, B. (2006) Cognitive Effects of Lamotrigine Compared with Topiramate in Patients with Epilepsy. Neurology, 67, 400-406. [Google Scholar] [CrossRef] [PubMed]
[30] Lee, S.-A., Lee, H.-W., Heo, K., Shin, D.-J. and Song, H.-K. (2010) Cognitive and Behavioral Effects of Lamotrigine and Carbamazepine Monotherapy in Patients with Newly Diagnosed or Untreated Partial Epilepsy. Seizure, 20, 49-54. [Google Scholar] [CrossRef] [PubMed]
[31] Gomer, B., Wagner, K., Frings, L., Saar, J. and Carius, A. (2007) The Influence of Antiepileptic Drugs on Cognition: A Comparison of Levetiracetam with Topiramate. Epilepsy & Behav-ior: E&B, 10, 486-494. [Google Scholar] [CrossRef] [PubMed]
[32] Piazzini, A., Chifari, R., Canevini, M.P., Turner, K. and Fontana, S.P. (2005) Levetiracetam: An Improvement of Attention and of Oral Fluency in Patients with Partial Epilepsy. Epilepsy Research, 68, 181-188. [Google Scholar] [CrossRef] [PubMed]
[33] Witt, J.-A., Elger, C.E. and Helmstaedter, C. (2012) Impaired Verbal Fluency under Topiramate—Evidence for Synergistic Negative Effects of Epilepsy, Topiramate, and Polytherapy. European Journal of Neurology, 20, 130-137. [Google Scholar] [CrossRef] [PubMed]
[34] Loring, D.W., Marino, S. and Meador, K.J. (2007) Neuro-psychological and Behavioral Effects of Antiepilepsy Drugs. Neuropsychology Review, 17, 413-425. [Google Scholar] [CrossRef] [PubMed]

为你推荐