阴道微生物与HPV持续感染的相关研究进展
Research Progress on the Relationship between Vaginal Microbiota and Persistent HPV Infection
DOI: 10.12677/ACM.2023.13102340, PDF,    科研立项经费支持
作者: 朱昱哲, 王梦媛, 张 颖：西安医学院研究生工作部，陕西 西安；陈丽宏*, 李 玢：陕西省人民医院妇科，陕西 西安
关键词: 阴道微生物；人乳头瘤病毒感染；乳杆菌；Vaginal Microbiota； Human Papillomavirus Infection； Lactobacillus
摘要: 阴道微生物群在女性生殖道的健康中起着关键作用，阴道微生物群失调可引起多种生殖道疾病。宫颈癌是常见的女性恶性肿瘤，持续人乳头瘤病毒感染(HPV)是导致宫颈上皮内瘤变和宫颈癌的高危因素。不同研究表明，阴道微生物多样性增加，乳杆菌丰度降低与HPV持续感染可能起协同作用。这为疾病的治疗提供了新的思路，深入研究阴道微生物在HPV持续感染中的作用机制，有助于个体化诊疗的发展。
Abstract: The vaginal microbiota plays a crucial role in the health of the female reproductive tract, and vagi-nal microbiota disorders can cause various reproductive tract diseases. Cervical cancer is a common malignant tumor in women, and persistent human papillomavirus infection (HPV) is a high-risk factor for cervical intraepithelial neoplasia and cervical cancer. Different studies have shown that an increase in vaginal microbial diversity, a decrease in lactobacillus abundance, and sustained HPV infection may have a synergistic effect. This provides new ideas for the treatment of diseases, and in-depth research on the mechanism of vaginal microbiota in persistent HPV infection is helpful for the development of personalized diagnosis and treatment.
文章引用：朱昱哲, 王梦媛, 张颖, 陈丽宏, 李玢. 阴道微生物与HPV持续感染的相关研究进展[J]. 临床医学进展, 2023, 13(10): 16723-16730. https://doi.org/10.12677/ACM.2023.13102340

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