炎症细胞因子与宫颈重塑早产相关性的研究进展
Research Progress on the Association between Inflammatory Cytokines and Cervical Remodeling Leads to Premature Birth
DOI: 10.12677/ACM.2023.13102364, PDF,   
作者: 郭建华：内蒙古医科大学研究生院，内蒙古 呼和浩特；乌日古木拉*：内蒙古妇幼保健院妇科，内蒙古 呼和浩特；姜 雯：内蒙古妇幼保健院生殖医学科，内蒙古 呼和浩特
关键词: 宫颈重塑；炎症；细胞因子；宫颈结构；发病机制；Cervical Remodeling； Inflammation； Cytokines； The Structure of Cervix； Pathogenesis
摘要: 宫颈作为子宫和阴道之间的动态保护屏障。宫颈的组织结构动态变化和由此产生的解剖学变化称为宫颈重塑。然而目前导致宫颈过早重塑而发生早产的发生机制仍不十分明确。近期研究认为，在宫颈重塑炎症机制中细胞因子(CK)不仅可以在免疫系统中构成网络互相联系，还可以调节内分泌系统导致宫颈结构及功能的变化，促进自发性早产的发生发展。本文通过回顾宫颈及孕期宫颈重塑的相关研究，对宫颈结构、功能和孕期宫颈重塑的组织结构变化进行系统阐述，总结细胞因子在足月或早产宫颈重塑机制中的研究进展。
Abstract: The cervix acts as a dynamic protective barrier between the uterus and the vagina. The dynamic changes in the tissue structure of the cervix and the resulting anatomical changes are called cervi-cal remodeling. However, the mechanisms that lead to premature cervical remodeling and preterm birth are still unclear. Recent studies suggest that cytokines (CK) in the mechanism of cervical re-modeling inflammation can not only form a network in the immune system, but also regulate the endocrine system, leading to changes in cervical structure and function, and promote the occur-rence and development of spontaneous preterm labor. By reviewing the relevant studies on cervical remodeling and cervical remodeling during pregnancy, this paper systematically elaborated the changes of cervical structure, function and tissue structure of cervical remodeling during pregnancy, and summarized the research progress of cytokines in the mechanism of cervical remodeling dur-ing term or preterm delivery.
文章引用：郭建华, 乌日古木拉, 姜雯. 炎症细胞因子与宫颈重塑早产相关性的研究进展[J]. 临床医学进展, 2023, 13(10): 16876-16882. https://doi.org/10.12677/ACM.2023.13102364

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