不同诱导剂构建的川崎病动物模型研究进展

Research Progress on Animal Models of Kawasaki Disease Constructed with Different Inducers

摘要: 川崎病(Kawasaki disease, KD)，又称皮肤黏膜淋巴结综合征，是一种常见于儿童的自身免疫性疾病，易引发儿童全身性血管炎，是儿童获得性心脏病的重要因素。KD的发病率逐年增高，但其发病机制目前尚不完全明晰，且病因复杂，误诊误治率极高，加之儿童组织标本取材困难，因此，理想动物模型的构建是亟待解决的重要问题。本文就KD发病机理、构建模型诱导剂、现有的动物模型诱导方案进行比较分析，为理想KD动物模型的构建奠定基础，为KD机制研究、新药研发及早期诊疗提供有益参考。

Abstract: Kawasaki disease (KD), also known as skin mucosal lymph node syndrome, is a common autoim-mune disease in children, which can easily cause systemic vasculitis and is an important factor in acquired heart disease in children. The incidence rate of KD is increasing year by year, but its pathogenesis is not clear at present, and the etiology is complex, the rate of misdiagnosis and mis-treatment is extremely high. In addition, it is difficult to obtain tissue samples from children. Therefore, the construction of an ideal animal model is an important problem to be solved urgently. This paper compares and analyzes the pathogenesis of KD, the inducers to construct KD animal model, and existing animal model induction schemes, which will lay the foundation for the con-struction of an ideal KD animal model, and provide useful references for the KD mechanism, new drug development, and early diagnosis and treatment.