脊柱结核病因病机及中医药抗结核机制研究进展
Research Progress on Pathogenesis of Spinal Tuberculosis and Anti-Tuberculosis Mechanism of Traditional Chinese Medicine
DOI: 10.12677/TCM.2023.1210470, PDF,    科研立项经费支持
作者: 黄鹤阳：湖北中医药大学第一临床学院，湖北 武汉；武汉市第一医院骨科，湖北 武汉；浦飞飞, 冯 晶：武汉市第一医院骨科，湖北 武汉；湖北中医药大学附属中西医结合医院骨科，湖北 武汉；夏 平*：湖北中医药大学第一临床学院，湖北 武汉；武汉市第四医院骨科，湖北 武汉
关键词: 脊柱结核；中医病因和病机；中医药；结核分枝杆菌；信号通路；Spinal Tuberculosis； Etiological Factors and Pathogenesis of TCM； Traditional Chinese Medicine； My-cobacterium Tuberculosis； Signaling Pathways
摘要: 脊柱结核是原发病灶的结核分枝杆菌经血行传播扩散到脊柱引起的感染性疾病。脊柱结核是脊柱感染性疾病中最常见的类型，同时也是肺外结核中最严重的形式之一，具有较高的致残率和致死率，对人们的生活健康造成了较为严重的危害。脊柱结核在中医学上归属“骨痨”、“龟背痰”或“流痰”范畴，由“本虚”及外感“痨虫”所致，外感六淫、情志过极、外部损伤是引起发病的常见诱因。目前，对于该病的治疗以西医化疗及手术治疗为主，辅以中医内外治疗。本文综述了近年来有关脊柱结核的病因病机和中医药抗结核机制研究最新进展，以期为脊柱结核的中医综合治疗提供崭新的视角和全新的临床指导。
Abstract: Spinal tuberculosis is an infectious disease caused by the spread of tuberculosis bacilli from a pri-mary lesion through the bloodstream to the spine. It is the most common type of spinal infectious disease and one of the most severe forms of extrapulmonary tuberculosis, with high rates of disabil-ity and mortality, causing significant harm to people’s health and daily lives. In traditional Chinese medicine, spinal tuberculosis is classified as “bone consumption” “turtle-back phlegm” or “flowing phlegm” which is caused by “ben xu” and external “lao chong”. Common causes of the disease in-clude external injury, extreme emotional stress, and exposure to six external pathogenic factors. Currently, the main treatment options for this disease are Western medicine chemotherapy and surgery, along with traditional Chinese medicine internal and external therapies. This article re-views the latest progress in the pathogenesis and anti-tuberculosis mechanisms of traditional Chi-nese medicine for spinal tuberculosis in recent years, with the aim of providing new perspectives and clinical guidance for the integrated treatment of spinal tuberculosis in traditional Chinese medicine.
文章引用：黄鹤阳, 浦飞飞, 夏平, 冯晶. 脊柱结核病因病机及中医药抗结核机制研究进展[J]. 中医学, 2023, 12(10): 3137-3145. https://doi.org/10.12677/TCM.2023.1210470

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