膀胱癌淋巴结转移的危险因素分析及临床意义探讨

Risk Factor Analysis and Clinical Significance Discussion of Lymph Node Metastasis in Bladder Cancer

摘要: 目的：探讨膀胱癌淋巴结转移的相关危险因素。方法：收集我院2008年1月~2021年8月收治的172例膀胱癌根治术患者临床资料，分析探讨淋巴结转移的影响因素。结果：膀胱癌患者淋巴结转移情况仅在电切标本浸润程度、病理标本浸润程度、是否血管淋巴浸润方面有显著差异，P < 0.05。多因素回归分析显示淋巴结转移与两项因素有关，电切病理标本浸润至肌层患者发生淋巴结转移的可能性是未浸润至肌层患者的5.619倍(P < 0.05)，发生血管淋巴浸润的患者淋巴结转移的可能性是未发生的7.995倍(P < 0.05)。结论：电切病理标本浸润至肌层以及发生血管淋巴浸润会显著增加淋巴结转移可能。采取综合治疗措施以及积极的态度来治疗有以上危险因素的患者至关重要。

Abstract: Objective: To investigate the risk factors of lymph node metastasis in bladder cancer. Methods: The clinical data of 172 patients with bladder cancer who underwent radical surgery in our hospital from January 2008 to August 2021 were collected, and the influencing factors of lymph node me-tastasis were analyzed. Results: The lymph node metastasis of bladder cancer patients was signifi-cantly different only in the degree of invasion of resected specimens, the degree of invasion of pathological specimens, and whether there was vascular lymph infiltration (P < 0.05). Multivariate regression analysis showed that lymph node metastasis was related to two factors. Patients with pathological specimen infiltration into the muscle layer were 5.619 times more likely to have lymph node metastasis than those without infiltration into the muscle layer (P < 0.05), and patients with vascular lymphatic infiltration were 7.995 times more likely to have lymph node metastasis than those without infiltration (P < 0.05). Conclusion: The infiltration of pathological specimens into the muscle layer and the occurrence of vascular lymphatic infiltration significantly increase the possi-bility of lymph node metastasis. It is crucial to adopt comprehensive treatment measures and a positive attitude to treat patients with the above risk factors.