磁共振扩散成像在评估胶质瘤IDH-1基因分型及肿瘤增殖活性方面的研究进展
Research Progress of Magnetic Resonance Diffusion Imaging in IDH-1 Genotypes and Tumor Proliferation in Gliomas
摘要: 胶质瘤占原发性中枢神经系统恶性肿瘤的80%，是大多数脑肿瘤相关死亡的原因；不同类型的胶质瘤治疗方式的选择及预后是不同的；2016年，中枢神经系统(CNS)肿瘤分类首次将分子表型纳入了胶质瘤的分类标准，其中包括异柠檬酸脱氢酶-1 (IDH-1)，它是神经胶质瘤诊断和预后最相关的分子标志物，Ki-67增殖指数常用于评估细胞增殖活性，与肿瘤恶性程度密切相关；磁共振扩散成像(dMRI)可以通过检测组织中水分子的微观运动特征，反映肿瘤的异质性及细胞增殖情况；本篇综述整合了几种不同类型扩散模式在胶质瘤基因分型、增殖活性方面的应用，希望可以为临床术前评估提供有效的影像学帮助。
Abstract: Gliomas account for 80% of primary central nervous system malignancies and are the cause of most brain tumor related deaths. The choice of treatment methods and prognosis vary for different types of gliomas. In 2016, the central nervous system (CNS) tumor classification first included molecular phenotypes in the classification criteria for gliomas, including isocitrate dehydrogenase 1 (IDH-1), which is the most relevant molecular marker for the diagnosis and prognosis of gliomas. The Ki-67 proliferation index is commonly used to evaluate cell proliferation activity and is closely related to the malignancy of tumors. Magnetic resonance diffusion imaging (dMRI) can reflect the heterogene-ity of tumors and cell proliferation by detecting the microscopic motion characteristics of water molecules in tissues. This review integrates several different types of diffusion patterns in the ap-plication of glioma genotyping and proliferative activity, hoping to provide effective imaging assis-tance for clinical preoperative evaluation.
文章引用：赵淑琴, 丁爽. 磁共振扩散成像在评估胶质瘤IDH-1基因分型及肿瘤增殖活性方面的研究进展[J]. 临床医学进展, 2023, 13(11): 17266-17274. https://doi.org/10.12677/ACM.2023.13112419

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