非酒精性脂肪肝患者心血管风险的研究现状

Current Status of Research on Cardiovascular Risk in Patients with Non-Alcoholic Fatty Liver Disease

摘要: 非酒精性脂肪肝(Non-Alcoholic Fatty Liver Disease, NAFLD)是慢性肝病的主要原因，被认为是代谢综合征的肝脏表现。NAFLD与胰岛素抵抗、肥胖、血脂异常、糖尿病等因素密切相关，这些因素也是心血管疾病的危险因素。研究数据表明心血管疾病是目前NAFLD患者死亡的主要原因，所以有大量的研究探讨NAFLD与心血管疾病之间的联系，其中有很多研究指出NAFLD可能是促进动脉粥样硬化和冠心病发生发展的独立危险因素。因此，进一步了解NAFLD与心血管疾病之间的关系，以及这种关系的发生机制是非常重要的，这将有利于在一定程度上减少心血管疾病的发病率和病死率。

Abstract: Non-alcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease and is considered to be the hepatic manifestation of the metabolic syndrome. NAFLD is strongly associated with insu-lin resistance, obesity, dyslipidemia and diabetes, which are also risk factors for cardiovascular disease. Research data suggest that cardiovascular disease is currently the leading cause of death in patients with NAFLD, so there are a large number of studies exploring the link between NAFLD and cardiovascular disease, with many of them pointing to the possibility that NAFLD may be an inde-pendent risk factor that promotes the development of atherosclerosis and coronary atherosclerotic heart disease. Therefore, it is important to further understand the relationship between NAFLD and cardiovascular disease, as well as the mechanisms by which this relationship occurs, which will help to reduce the incidence of cardiovascular disease and morbidity and mortality to a certain extent.