急性冠脉综合征患者中性粒细胞/淋巴细胞比值与动脉粥样硬化指数的相关性分析
Correlation Analysis between Neutrophil/Lymphocyte Ratio and Atherosclerosis Index in Patients with Acute Coronary Syndrome
DOI: 10.12677/ACM.2023.13112452, PDF,    科研立项经费支持
作者: 郭 琰*, 向定成, 黎 思, 官 格#：南部战区总医院心血管内科，广东 广州；张群辉：南华大学衡阳医学院，附属第一医院，心血管内科，湖南 衡阳；心脏疾病多组学与人工智能湖南省重点实验室，湖南 衡阳；湖南省心肌损伤临床医学研究中心，湖南 衡阳；南华大学衡阳医学院，附属第一医院，心血管疾病研究所，湖南 衡阳
关键词: 急性冠脉综合征；中性粒细胞/淋巴细胞比值；动脉粥样硬化指数；Acute Coronary Syndrome； Neutrophil/Lymphocyte Ratio； Atherosclerosis Index
摘要: 目的：评估中性粒细胞/淋巴细胞比值(NLR)与急性冠脉综合征(ACS)患者动脉粥样硬化指数(AI)的关系。方法：纳入2022年10月至2023年2月在南部战区总医院接受冠状动脉造影的患者98例，根据入院时AI分成高AI组和低AI组。研究两组基线资料与实验室指标与AI的关系。结果：纳入人群包括98例，低AI组49例，高AI组49例。两组在甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、中性粒细胞、淋巴细胞和NLR方面差异存在统计学意义(P < 0.05)。NLR与AI呈正相关(r = 0.362, P < 0.05)。多因素logistic回归分析显示NLR能独立预测ACS患者AI。高AI组的血运重建患者人数明显高于低AI组的患者人数。结论：入院时NLR与ACS患者的AI相关，提示NLR可作为预测ACS患者AI的指标。
Abstract: Objective: To evaluate the relationship between the neutrophil/lymphocyte ratio (NLR) and arteri-osclerosis index (AI) in patients with acute coronary syndrome (ACS). Methods: Ninety-eight pa-tients who underwent coronary angiography at the General Hospital of Southern Theater Command of PLA from October 2022 to February 2023 were included and divided into high and low AI groups according to the atherosclerosis index (AI) at admission. The relationship between baseline data and laboratory parameters and AI was studied. Results: Ninety-eight patients were included in the study, 49 in the low AI group and 49 in the high AI group. There were significant differences in tri-glyceride, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, neutrophils, lymphocytes and NLR between the two groups (P < 0.05). NLR was positively correlated with AI (r = 0.362, P < 0.05). Multivariate logistic regression analysis showed that NLR could inde-pendently predict AI in patients with ACS. The number of patients with revascularization was sig-nificantly higher in the high AI group than in the low AI group (P < 0.05). Conclusions: NLR at ad-mission was associated with AI in ACS patients, suggesting that NLR could be used as a predictor of AI in ACS patients.
文章引用：郭琰, 向定成, 张群辉, 黎思, 官格. 急性冠脉综合征患者中性粒细胞/淋巴细胞比值与动脉粥样硬化指数的相关性分析[J]. 临床医学进展, 2023, 13(11): 17502-17508. https://doi.org/10.12677/ACM.2023.13112452

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