含醇手消毒剂中有效成分及杂质的测定方法比较研究

A Comparative Study on Determination Methods for Active Ingredients and Impurities in Alcohol-Containing Hand Disinfectants

摘要: 在对现有方法进行分析比较的基础上提出了4种可行的适用于含醇消毒剂中有效成分及有害杂质的测定方法。提出的方法对于四种目标物的标准曲线线性相关系数介于0.9972~1.0000之间，检出限介于0.02 (V/V)%~2.22 (V/V)%之间，定量限介于0.05~7.39 (V/V)%，峰面积或校正因子的精密度介于0.1%~3.8%之间，加标回收率介于95.7%~101.7%之间，并据此对实际检测工作流程给出了相应建议。结果显示，提出的4种方法均可用于含醇消毒剂中有效成分及有害杂质的测定，其中内标法的准确度优于外标法，建议将内标法作为仲裁方法加入标准。

Abstract: Based on the analysis and comparison of the existing methods, four feasible methods for the deter-mination of active components and harmful impurities in alcohol-containing disinfectants were proposed. The linear correlation coefficient of the standard curves of the proposed method ranged from 0.9972 to 1.0000; the detection limit ranged from 0.02 to 2.22 (V/V)%; the quantitation limit ranged from 0.05 to 7.39 (V/V)%; and the precision of the peak area or correction factor ranged from 0.1 to 3.8%. The recovery rate of standard addition is between 95.7% and 101.7%, and the corresponding suggestions are given for the actual testing process. The results show that the four methods proposed can be used for the determination of active components and harmful impurities in alcohol-containing disinfectants, and the accuracy of the internal standard method is better than that of the external standard method. It is suggested that the internal standard method should be added to the standard as an arbitration method.