基于肠道菌群探究结直肠癌肿瘤微环境参与免疫逃逸机制
Exploring the Involvement of Tumor Microenvironment in Immune Escape Mechanisms in Colorectal Cancer Based on Gut Microbiota
DOI: 10.12677/ACM.2023.13112490, PDF,   
作者: 吴秋梦：黑龙江中医药大学研究生院，黑龙江 哈尔滨；张雅楠：黑龙江省中医药科学院，黑龙江 哈尔滨；陈 宏*：黑龙江省中医医院肿瘤科，黑龙江 哈尔滨
关键词: 结直肠癌；肠道菌群；短链脂肪酸；肿瘤微环境；免疫逃逸；Colorectal Cancer； Gut Microbiota； Short Chain Fatty Acids； Tumor Microenvironment； Immune Escape
摘要: 结直肠癌作为全球面临的具有高发病率以及高死亡率的癌症，一直以来都是人们关注的热点。肿瘤微环境，是癌性组织周围非癌细胞的成分，包括细胞外基质、肿瘤相关免疫细胞以及细胞因子等，肿瘤微环境为瘤细胞提供了“免疫特权”，免受机体免疫监控，从而形成免疫逃逸。肠道菌群是生活在肠道的一个庞大族群，具有“人类第二基因族群”的称号，多数结直肠癌症患者肠道菌群会出现紊乱。本文主要回顾肠道菌群影响结直肠癌微环境以及免疫逃逸的过程，为调节肠道菌群治疗结直肠癌的应用提供理论依据。
Abstract: Colorectal cancer, as a global cancer with high incidence rate and high mortality, has always been the focus of attention. The tumor microenvironment is a component surrounding cancerous tissue but non-cancerous cells, including extracellular matrix, tumor related immune cells, and cytokines. The tumor microenvironment provides “immune privilege” for tumor cells, avoiding immune mon-itoring by the body, and thus forming immune escape. The gut microbiota is a large group of people living in the intestines, known as the “second gene group of humans”, and most patients with colo-rectal cancer experience disorders in the gut microbiota. This article mainly reviews the process of gut microbiota affecting the microenvironment and immune escape of colorectal cancer, providing a theoretical basis for regulating the application of gut microbiota in the treatment of colorectal can-cer.
文章引用：吴秋梦, 张雅楠, 陈宏. 基于肠道菌群探究结直肠癌肿瘤微环境参与免疫逃逸机制[J]. 临床医学进展, 2023, 13(11): 17757-17763. https://doi.org/10.12677/ACM.2023.13112490

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