揿针疗法对痔疮术后患者血清炎性因子表达水平的影响

Effect of Acupuncture on Expression of Serum Inflammatory Factors in Patients with Hemorrhoids after Operation

摘要: 疼痛是痔疮患者手术后重要并发症，术后疼痛会影响患者恢复时间并可能诱发更为严重并发症，目前仍依赖于多次服用止痛药物，并无其他治疗方法。揿针属于中医针灸的一种，具有简单方便等诸多优势。前期研究表明揿针疗法可以显著减轻痔疮患者手术后，且炎症水平与疼痛存在密切联系。本研究拟采用揿针疗法治疗痔疮术后疼痛，并采用ELISA法检测患者揿针治疗前后血清中促炎细胞因子IL-6和TNF-α水平。研究发现，痔疮患者手术后血清中促炎细胞因子IL-6和TNF-α水平明显高于健康者，但经揿针治疗72 h后血清中IL-6和TNF-α水平显著下降(P < 0.05)；并且患者疼痛VAS积分感觉明显减轻(P < 0.05)。研究结果表明，经揿针治疗后患者体内炎症水平明显降低，揿针疗法可能是通过抑制体内炎症发挥止痛作用的。

Abstract: Pain is an important complication in patients with hemorrhoids after surgery. Postoperative pain can affect the recovery time of patients and may induce more serious complications. At present, it still depends on multiple analgesics and there is no other treatment method. Acupuncture is a kind of traditional Chinese medicine acupuncture, which has many advantages such as simplicity and convenience. Previous studies have shown that acupuncture therapy can significantly relieve hem-orrhoid patients after surgery, and the level of inflammation is closely related to pain. In this study, acupuncture was used to treat postoperative pain of hemorrhoids, and serum levels of pro-inflammatory cytokines IL-6 and TNF-α were detected by ELISA before and after acupuncture. The results showed that the serum levels of proinflammatory cytokines IL-6 and TNF-α in patients with hemorrhoids after operation were significantly higher than those in healthy subjects, but the serum levels of IL-6 and TNF-α were significantly decreased after 72 h of acupuncture treatment (P < 0.05). Moreover, the pain VAS score of patients was significantly reduced (P < 0.05). The results showed that the level of inflammation in the body was significantly reduced after the acupuncture treatment, and the acupuncture therapy may play an analgesic role by inhibiting the inflammation in the body.