N-亚硝胺类化合物检测研究进展
Research Progress on the Detection of N-Nitrosamines Compounds
DOI: 10.12677/AAC.2023.134054, PDF,   
作者: 詹 健, 朱登文, 张甲利, 张生宏, 黎文海*:中国药科大学,理学院,江苏 南京
关键词: N-亚硝胺基因毒性检测方法基质N-Nitrosamines Genotoxicity Detection Methods Matrix
摘要: N-亚硝胺类化合物由于其本身和代谢后的产物都会对人体造成严重的破坏甚至发生癌变。所以一直以来作为一类重要的基因毒性杂质,对其分析方法的开发就备受关注。本文将对N-亚硝胺类化合物的致病机理以及在不同条件下的产生途径进行讨论,并着重介绍在食品、烟草、化妆品、水体、日用品、药品等不同基质中的检测方法的最新进展。
Abstract: N-nitrosamine compounds can cause serious damage to the human body and even cancer due to their own and metabolic products. Therefore, as an important class of genotoxic impurities, the de-velopment of its analytical methods has attracted much attention. In this paper, the pathogenic mechanism of N-nitrosamines and their production pathways under different conditions are dis-cussed, and the latest progress of detection methods in different matrices such as food, tobacco, cosmetics, water, daily necessities and drugs is introduced.
文章引用:詹健, 朱登文, 张甲利, 张生宏, 黎文海. N-亚硝胺类化合物检测研究进展[J]. 分析化学进展, 2023, 13(4): 513-522. https://doi.org/10.12677/AAC.2023.134054

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