慢性鼻窦炎的内型与临床诊疗相关研究进展

Research Progress on the Internal Types of Chronic Sinusitis and Its Clinical Diagnosis and Treatment

摘要: 慢性鼻窦炎(chronic rhinosinusitis, CRS)是一种常见的临床综合征，给我们的卫生系统带来了巨大的发病率和成本。CRS的研究已经从一个以表型为中心的时代发展到包括以内型为基础的信息时代。表型分类根据内镜观察到的特征(如是否有鼻息肉、是否有合并症或全身性疾病以及疾病发病时间)确定了CRS的临床异质性。最近，基于实验室的研究结果根据特定的机制或分子生物标志物确定了CRS的内分型。临床内分型疾病改进方法的开发和使用，正在扩大目前针对2型炎症的生物疗法的使用，也许在不久的将来会针对其他炎症内分型。本文从提高对CRS发病机制的认识、治疗方法和结局的角度出发，将结合近年来的研究对其进行综述。

Abstract: Chronic rhinosinusitis (CRS) is a common clinical syndrome, which brings huge morbidity and cost to our health system, the study of CRS has developed from aphenotype-centered era to an infor-mation age based on endogenous types. Phenotypic classification has determined the clinical het-erogeneity of CRS based on endoscopic features such as the presence of nasal polyps, the presence of comorbidities or systemic diseases, and the timing of disease onset. Recently, based on laboratory research results, the internal typing of CRS was determined according to specific mechanisms or molecular biomarkers. The development and use of improved methods for clinical classification of diseases are expanding the use of biotherapy for type 2 inflammation at present, and may be aimed at other types of inflammation in the near future. In order to improve the understanding of the pathogenesis, treatment and outcome of CRS, this paper will review it with the research in recent years.