决明子在眼科疾病中的应用研究进展
Research Progress on Application of Cassia Seed in Ophthalmic Diseases
DOI: 10.12677/ACM.2023.13112593, PDF,   
作者: 段孟云:黑龙江中医药大学第一临床医学院,黑龙江 哈尔滨
关键词: 决明子眼科疾病作用机制古籍记载药理作用应用Cassia Seed Ophthalmic Diseases Mechanism of Action Ancient Records Pharmacological Action Application
摘要: 决明子是药食两用的中药,以其清肝明目、润肠通便而广受人们的喜爱,可用于治疗多种眼科疾病,如青光眼、白内障、玻璃体混浊、视网膜病变等。近年来,决明子在眼科疾病中的应用研究取得了长足进步,显示了较好的临床应用前景。本文对决明子在眼科疾病中的作用机制进行总结归纳,分别从古籍记载、药理作用、临床应用3个方面进行阐述,以期为决明子在眼科疾病中的深入研究和广泛应用提供参考。同时也指出目前决明子在眼科疾病中的研究仍存在一些问题,如决明子的有效成分提取分离和药理作用研究等还有待进一步加强。
Abstract: Cassia seed is a traditional Chinese medicine with dual functions of medicine and food. It is widely loved by people for clearing away the liver, improving eyesight and relaxing bowels. It can be used to treat many eye diseases, such as glaucoma, cataract, vitreous opacity and retinopathy. In recent years, the application research of cassia seed in ophthalmic diseases has made great progress, showing a good clinical application prospect. In this paper, the mechanism of action of Semen Cas-siae in ophthalmic diseases is summarized, and it is expounded from three aspects: ancient records, pharmacological action and clinical application, so as to provide reference for the in-depth research and wide application of Semen Cassiae in ophthalmic diseases. At the same time, it is also pointed out that there are still some problems in the research of cassia seed in ophthalmic diseases, such as the extraction and separation of effective components of cassia seed and the study of pharmacolog-ical effects, which need to be further strengthened.
文章引用:段孟云. 决明子在眼科疾病中的应用研究进展[J]. 临床医学进展, 2023, 13(11): 18461-18464. https://doi.org/10.12677/ACM.2023.13112593

参考文献

[1] 顾观光. 神农本草经∙卷二[M]. 第3版. 杨鹏举, 校注. 北京: 学苑出版社, 2007: 78.
[2] (清)张秉成. 本草便读[M]. 上海: 上海卫生出版社, 1957.
[3] 陈嘉谟, 编. 本草蒙筌[M]. 北京: 人民卫生出版社, 1988.
[4] (明)卢之颐. 本草乘雅半偈[M]. 北京: 中国中医药出版社, 2016.
[5] 王怀隐. 太平圣惠方[J]. 北京: 人民卫生出版社, 1958.
[6] Guo, X.W., Sun, J.H., et al. (2015) Simultaneous Determination of Seven Anthraquinones in Rat Plasma by Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry and Pharmacokinetic Study after Oral Ad-ministration of Semen Cassiae Extract. Journal of Ethnopharmacology, 169, 305-313.
[7] 贾振宝, 陈文伟, 蒋家新, 等. 决明子中蒽醌类化学成分的研究[J]. 林产化学与工业, 2009, 29(3): 100-102.
[8] 冯蕾. 决明子水溶性多糖的精细结构、构象特征及其流变行为研究[D]: [博士学位论文]. 南昌: 南昌大学, 2023.
[9] Fatmawati, S., Yu-liana, Purnomo, A.S. and Abu Bakar, M.F. (2020) Chemical Constituents, Usage and Pharmacological Activity of Cas-sia alata. Heliyon, 6, e04396. [Google Scholar] [CrossRef] [PubMed]
[10] 杨冰, 任娟, 秦昆明, 等. 决明子药理作用及其机制研究进展[J]. 中药材, 2018, 41(5): 1247-1251. [Google Scholar] [CrossRef
[11] 张晓贤, 张淼, 王妍, 苗芳, 周乐. 决明子萌发过程中抗氧化活性变化研究[J]. 西北植物学报, 2011, 31(2): 393-397.
[12] Nakano, M., Orimo, N., Katagiri, N., et al. (2008) Inhibitory Effect of Astraxanthin Combined with Flavangenol on Oxidative Stress Biomarkers in Streptozoto-cin-Induced Diabetic Rats. International Journal for Vitamin & Nutrition Research, 78, 175-182. [Google Scholar] [CrossRef] [PubMed]
[13] 曹平, 苏露煜. 决明子多糖调节IL-6/JAK2/STAT3通路对高糖诱导视网膜神经节细胞损伤的影响[J]. 河北医药, 2023, 45(9): 1297-1301.
[14] 孙苗苗. 决明子多糖提取物上调Nrf2/HO-1信号轴对糖尿病视网膜内皮细胞的保护及作用机制[D]: [硕士学位论文]. 杭州: 浙江大学, 2023.[CrossRef
[15] 唐紫涵. 基于网络药理学及分子对接探讨决明子对干眼的治疗机制[J]. 山东化工, 2023, 52(5): 43-49. [Google Scholar] [CrossRef
[16] Meng, Y., Liu, Y., Fang, N. and Guo, Y.M. (2019) Hepatoprotective Effects of Cassia Semen Ethanol Extract on Non-Alcoholic Fatty Liver Disease in Experimental. Pharmaceutical Biology, 57, 98-104. [Google Scholar] [CrossRef] [PubMed]
[17] Nawabjohn, M., Sivaprakasam, P., Anandasadagopan, S., et al. (2022) Green Synthesis and Characterisation of Silver Nanoparticles Using Cassia tora Seed Extract and Investiga-tion of Antibacterial Potential. Applied Biochemistry and Biotechnology, 194, 464-478.
[18] Wang, Q.Y., Tong, A.H., et al. (2019) The Effect of Cassia Seed Extract on the Regulation of the LKB1-AMPK-GLUT4 Signaling Pathway in the Skeletal Muscle of Diabetic Rats to Improve the Insulin Sensitivity of the Skeletal Muscle. Diabetology & Metabolic Syndrome, 11, Article No. 108. [Google Scholar] [CrossRef] [PubMed]
[19] Ko, E., Um, M.Y., Choi, M., et al. (2020) Cassia tora Seed Improves Pancreatic Mitochondrial Function Leading to Recovery of Glucose Metabolism. The American Journal of Chinese Medicine, 48, 615-629. [Google Scholar] [CrossRef
[20] Kim, D.S., Zhang, T. and Park, S. (2022) Protective Effects of Forsythiae fructus and Cassiae semen Water Extract against Memory Deficits through the Gut-Microbiome-Brain Axis in an Alzheimer’s Disease Model. Pharmaceutical Biology, 60, 212-224. [Google Scholar] [CrossRef] [PubMed]
[21] Patil, U.K., Saraf, S. and Dixit, V.K. (2004) Hypolipidemic Activity of Seeds of Cassia tora Linn. Journal of Ethnopharmacology, 90, 249-252. [Google Scholar] [CrossRef] [PubMed]
[22] Yu, H.L., Liu, C.J., Wang, Y.F. and Chen, J.S. (2014) The Effects of Semen Cassiae Anthraquinone Glycoside on Blood Pressure and Kidney Injury Protection: A Study in Two-Kidney One Clip Hypertensive Rats. Journal of Clinical and Experimental Medicine, No. 9, 692-695.
[23] Liu, C., Liu, Q., Sun, J., et al. (2014) Extraction of Water-Soluble Polysaccharide and the Antioxidant Activity from Semen cassiae. Journal of Food & Drug Analysis, 22, 492-499. [Google Scholar] [CrossRef] [PubMed]
[24] Zhao, X., et al. (2014) Anti-tumor Activities of Juemingzi (Cassia tora L.) on Balb/c Sarcoma 180-Injected Mice. Oncology Letters, 7, 250-254. [Google Scholar] [CrossRef] [PubMed]
[25] Sabapathy, I., Periyasamy, V., Jayaraman, S. and Rajalakshmi, M. (2021) Novel Triterpenoids from Cassia fistula Stem Bark Depreciates STZ-Induced Detrimental Changes in IRS-1/Akt-Mediated Insulin Signaling Mechanisms in Type-1 Diabetic Rats. Molecules, 26, Article 6812. [Google Scholar] [CrossRef] [PubMed]
[26] 郭海叶. 自拟补肾通络明目汤对青光眼术后视神经功能的影响[J]. 实用防盲技术, 2018, 13(3): 123-124, 94. [Google Scholar] [CrossRef
[27] 王彤云. 洪宜成辨治眼病经验撷萃[J]. 江苏中医药, 2004, 25(6): 9-10.
[28] 邵鸿展. 决明子对糖尿病患者玻璃体视网膜术后高眼压的预防作用[J]. 糖尿病新世界, 2020, 23(1): 171-173. [Google Scholar] [CrossRef
[29] 周小玲, 曾锦兰, 毛仕玲. 决明子薄荷冰片热奄包配合护理干预缓解眼症疼痛的临床观察[J]. 深圳中西医结合杂志, 2014, 24(6): 48-49. [Google Scholar] [CrossRef
[30] 姚贤凤, 王利民, 陈梅. 疏肝健脾法联合中药电离子透入对青年干眼患者视功能、泪液分泌和泪液中IL-1β、TNF-α表达的影响[J]. 眼科新进展, 2019, 39(2): 149-152. [Google Scholar] [CrossRef