以高钙危象为首发表现的超高龄多发性骨髓瘤1例报告
A Case Report of Multiple Myeloma in the Over-Aged with Hypercalcemic Crisis as the First Manifestation
摘要: 目的:报道以高钙危象为首发表现的超高龄多发性骨髓瘤1例。病例介绍:患者,男性,92岁,因“出现意识障碍4日,加重1日”于2022年4月1日入住陕西省人民医院老年病科。入院后,以高钙危象为首发表现,给予紧急降钙、维持机体内环境稳定治疗后血钙降至正常水平,后寻找高钙血症病因,诊断多发性骨髓瘤。结论:高钙危象是一种重要的电解质紊乱,最终的疗效取决于病因学,因此迅速而准确地找出病因,治疗原发病,指导个体化和精准性诊疗对高钙危象的患者至关重要。
Abstract:
Objective: To report a case of multiple myeloma in the over-aged with hypercalcemic crisis as the first manifestation. Case Description: The patient, male, 92 years old, was admitted to the Depart-ment of Geriatrics of Shaanxi Provincial People’s Hospital on 1 April 2022 because of “disturbance of consciousness for 4 days, aggravating for 1 day”. After being admitted to the geriatrics department of Shaanxi Provincial People’s Hospital, the first manifestation of hypercalcemic crisis was given, and the blood calcium was reduced to normal level after emergency treatment of lowering calcium and maintaining the stability of the internal environment, and then the cause of hypercalcemia was searched for, and the diagnosis of multiple myeloma was made. Conclusion: Hypercalcemic crisis is an important electrolyte disorder and the final outcome depends on the etiology. Therefore, rapid and accurate identification of the cause, treatment of the primary disease, guidance of individual-ised and precise diagnosis and treatment are essential for patients with hypercalcemic crisis.
参考文献
|
[1]
|
Tonon, C.R., Silva, T., Pereira, F.W.L., et al. (2022) A Review of Current Clinical Concepts in the Pathophysiology, Eti-ology, Diagnosis, and Management of Hypercalcemia. Medical Science Monitor, 28, e935821. [Google Scholar] [CrossRef]
|
|
[2]
|
樊海悦, 田文青, 周波. 原发性甲状旁腺功能亢进症定位诊断[J]. 中华骨质疏松和骨矿盐疾病杂志, 2018, 11(2): 215-219.
|
|
[3]
|
Wu, J.X. and Yeh, M.W. (2016) Asymptomatic Prima-ry Hyperparathyroidism: Diagnostic Pitfalls and Surgical Intervention. Surgical Oncology Clinics, 25, 77-90. [Google Scholar] [CrossRef] [PubMed]
|
|
[4]
|
Banu, S., Batool, S., Sattar, S. and Masood, M.Q. (2021) Malignant and Non-Malignant Causes of Hypercalcemia: A Retrospective Study at a Tertiary Care Hospital in Pakistan. Cureus, 13, e15845. [Google Scholar] [CrossRef] [PubMed]
|
|
[5]
|
Gastanaga, V.M., Schwartzberg, L.S., Jain, R.K., et al. (2016) Prevalence of Hypercalcemia among Cancer Patients in the United States. Cancer Medicine, 5, 2091-2100. [Google Scholar] [CrossRef] [PubMed]
|
|
[6]
|
Hu, M.I. (2021) Hypercalcemia of Malignancy. Endocrinology and Metabo-lism Clinics of North America, 50, 721-728. [Google Scholar] [CrossRef] [PubMed]
|
|
[7]
|
董坤, 余学锋. 维生素D抵抗与代谢性骨病[J]. 内科急危重症杂志, 2021, 27(4): 265-267.
|