儿童心肌病心腔内血栓研究进展
Research Progress of Intracardiac Thrombus in Children with Cardiomyopathy
DOI: 10.12677/ACM.2023.13122608, PDF,   
作者: 张艳玲, 吕铁伟:重庆医科大学儿科学院,重庆医科大学附属儿童医院心血管内科,重庆;王娟莉:西安市儿童医院心血管内科,陕西 西安
关键词: 儿童抗凝治疗心腔内血栓Children Anticoagulant Therapy Intracardiac Thrombus
摘要: 心肌病是以心肌结构异常,伴有机械及电功能障碍的高度异质性心肌疾病,后期出现心脏增大,常表现为心力衰竭。心肌病心腔内血栓在儿童时期少见,但预后极差。是心肌病严重并发症之一。脱落的血栓可栓塞全身重要器官,可导致患者致残或者死亡,因此提高对儿童心肌病合并心腔内血栓的认识及其重要。近年来,心肌病心腔内血栓病因病机认识取得了较多进展。本文通过详细阐述儿童心肌病并发心腔内血栓的形成原理、风险因素以及诊断和治疗的进展,为未来的深入研究和治疗这种疾病提供理论支持和方向。
Abstract: Cardiomyopathy is a highly heterogeneous myocardial disease with abnormal myocardial structure and mechanical and electrical dysfunction. In the later stage, the heart appears enlarged and often presents with heart failure. Intracardiac thrombus in cardiomyopathy is rare in childhood, but the prognosis is extremely poor. It is one of the serious complications of cardiomyopathy. Shed throm-bus can embolize important organs of the whole body, which can lead to disability or death of pa-tients. Therefore, it is important to improve the understanding of children with cardiomyopathy complicated with intracardiac thrombus. This article elaborates the formation principle, risk fac-tors, diagnosis and treatment progress of children’s cardiomyopathy complicated with intracardiac thrombus, and provides theoretical support and direction for further research and treatment of this disease in the future.
文章引用:张艳玲, 吕铁伟, 王娟莉. 儿童心肌病心腔内血栓研究进展[J]. 临床医学进展, 2023, 13(12): 18559-18565. https://doi.org/10.12677/ACM.2023.13122608

参考文献

[1] Lipshultz, S.E., Law, Y.M., Asante-Korang, A., et al. (2019) Cardiomyopathy in Children: Classification and Diagnosis: A Scientific Statement from the American Heart Association. Circulation: An Official Journal of the American Heart As-sociation, 140, e9-e68. [Google Scholar] [CrossRef
[2] Bagnall, R., Singer, E., Wacker, J., et al. (2022) Genetic Basis of Childhood Cardiomyopathy. Circulation: Genomic and Precision Medicine, 15, e003686. [Google Scholar] [CrossRef
[3] 李自普. 儿童心肌病心力衰竭恶化的识别和处理[J]. 中国小儿急救医学, 2023, 30(1): 1-6.
[4] 中国医疗保健国际交流促进会精准心血管病分会, 心肌病抗凝治疗中国专家共识专家组, 宋雷, 等. 心肌病抗凝治疗中国专家共识[J]. 中国循环杂志, 2021, 36(12): 1148-1157. [Google Scholar] [CrossRef
[5] 中华医学会儿科学分会心血管学组儿童心肌病精准诊治协作组. 2006年至2018年国内33家医院4981例住院儿童心肌病调查分析[J]. 中华实用儿科临床杂志, 2021, 36(13): 983-989.
[6] Zuchi, C., Tritto, I., Carluccio, E., et al. (2020) Role of Endothelial Dysfunction in Heart Failure. Heart Failure Reviews, 25, 21-30. [Google Scholar] [CrossRef] [PubMed]
[7] Tsigkou, V., Oikonomou, E., Anastasiou, A., et al. (2023) Molecular Mechanisms and Therapeutic Implications of Endothelial Dys-function in Patients with Heart Failure. International Journal of Molecular Sciences, 24, Article No. 4321. [Google Scholar] [CrossRef] [PubMed]
[8] Feng, J., Liang, L., Chen, Y., et al. (2023) Big Endothelin-1 as a Pre-dictor of Reverse Remodeling and Prognosis in Dilated Cardiomyopathy. Journal of Clinical Medicine, 12, Article No. 1363. [Google Scholar] [CrossRef] [PubMed]
[9] Abudoukelimu, M., Ba, B., Kai, G.Y., et al. (2022) Von Wil-lebrand Factor (vWF) in Patients with Heart Failure with Preserved Ejection Fraction (HFpEF): A Retrospective Obser-vational Study. Medicine (Baltimore), 101, e29854. [Google Scholar] [CrossRef
[10] Reichman-Warmusz, E., Brzozowa-Zasada, M., Wojciechowska, C., et al. (2021) Decreased Immunoreactivity of von Willebrand Factor May Reflect Persistent Nature of the Endothelial Dysfunction in Non-Ischemic Heart Failure. Folia Histochemica et Cytobiologica, 59, 108-113. [Google Scholar] [CrossRef
[11] 孙慧超, 张蕾. 儿童心力衰竭过程中凝血功能变化及抗凝治疗[J]. 中国小儿急救医学, 2023, 30(1): 25-30.
[12] 李晓月. 慢性心力衰竭患者血小板活化及血小板参数的变化观察[J]. 中国现代药物应用, 2018, 12(20): 32-33.
[13] Zorlu, A., Yilmaz, M.B., Yucel, H., et al. (2012) Increased D-Dimer Levels Predict Cardiovascular Mortality in Patients with Systolic Heart Failure. Journal of Thrombosis and Thrombolysis, 33, 322-328. [Google Scholar] [CrossRef] [PubMed]
[14] Cruz Rodriguez, J.B., Okajima, K. and Greenberg, B.H. (2021) Management of Left Ventricular Thrombus: A Narrative Review. Annals of Translational Medicine, 9, 520. [Google Scholar] [CrossRef] [PubMed]
[15] 李清振. 心肌病, 心力衰竭与血栓形成[J]. 中国综合临床, 2001, 17(2): 90-91. [Google Scholar] [CrossRef
[16] Țăpoi, L., Șalaru, D.L., Sascău, R., et al. (2021) Uric Ac-id—An Emergent Risk Marker for Thrombosis? Journal of Clinical Medicine, 10, Article No. 2062. [Google Scholar] [CrossRef] [PubMed]
[17] Si, K., Wei, C., Xu, L., et al. (2021) Hyperuricemia and the Risk of Heart Failure: Pathophysiology and Therapeutic Implications. Frontiers in Endocrinology (Lausanne), 12, Article ID: 770815. [Google Scholar] [CrossRef] [PubMed]
[18] Xue, J., Ma, D., Jiang, J., et al. (2021) Diagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice? Journal of Inflammation Research, 14, 5059-5077. [Google Scholar] [CrossRef
[19] Tang, X., Wang, P., Zhang, R., et al. (2022) KLF2 Regulates Neutrophil Activation and Thrombosis in Cardiac Hypertrophy and Heart Failure Progression. The Journal of Clinical Investigation, 132, e147191. [Google Scholar] [CrossRef
[20] Ahmed, M., El Amrousy, D., Hodeib, H., et al. (2023) Neutro-phil-to-Lymphocyte Ratio as a Predictive and Prognostic Marker in Children with Dilated Cardiomyopathy. Cardiology in the Young, 1-5. [Google Scholar] [CrossRef
[21] Tang, L., Xia, Y. and Fang, L. (2022) Correlation between Left Atrial Thrombosis and Neutrophil-to-Lymphocyte Ratio upon Non-Valvular Atrial Fibrillation. Clinical Laboratory, 68, 1-4. [Google Scholar] [CrossRef
[22] 张波涛, 张婷, 马萍, 等. 扩张型心肌病左室附壁血栓的危险因素分析[J]. 宁夏医学杂志, 2019, 41(5): 449-451.
[23] Haybar, H., Pezeshki, S.M.S. and Saki, N. (2019) Evalua-tion of Complete Blood Count Parameters in Cardiovascular Diseases: An Early Indicator of Prognosis? Experimental and Molecular Pathology, 110, Article ID: 104267. [Google Scholar] [CrossRef] [PubMed]
[24] Pearson, A.C. (1993) Transthoracic Echocardiography versus Transesophageal Echocardiography in Detecting Cardiac Sources of Embolism. Echocardiography, 10, 397-403. [Google Scholar] [CrossRef] [PubMed]
[25] 何钗, 杨英. 心脏磁共振在房颤患者左心房/左心耳血栓检测中的应用进展[J]. 分子影像学杂志, 2019, 42(1): 27-30.
[26] Roifman, I., Connelly, K.A., Wright, G.A., et al. (2015) Echocardiography vs. Cardiac Magnetic Resonance Imaging for the Diagnosis of Left Ventricular Thrombus: A Systematic Review. Canadian Journal of Cardiology, 31, 785-791. [Google Scholar] [CrossRef] [PubMed]
[27] 吴昊晟, 汤日波. 扩张型心肌病合并左心室血栓的研究进展[J]. 心肺血管病杂志, 2023, 42(1): 84-87.
[28] Hirono, K., Takarada, S., Miyao, N., et al. (2022) Thromboembolic Events in Left Ventricular Non-Compaction: Comparison between Children and Adults—A Systematic Review and Me-ta-Analysis. Open Heart, 9, e001908. [Google Scholar] [CrossRef] [PubMed]
[29] 张蕾, 田杰. 《儿童心力衰竭诊断和治疗建议(2020年修订版)》发布[J]. 中华医学信息导报, 2021, 36(4): 20.
[30] Hirsh, J., Raschke, R., Warkentin, T.E., et al. (1995) Heparin: Mechanism of Action, Pharmacokinetics, Dosing Considerations, Monitoring, Efficacy, and Safety. Chest, 108, 258S-275S. [Google Scholar] [CrossRef
[31] McMichael, A.B.V., Ryerson, L.M., Ratano, D., et al. (2022) 2021 ELSO Adult and Pediatric Anticoagulation Guidelines. ASAIO Journal, 68, 303-310. [Google Scholar] [CrossRef
[32] Monagle, P. and Newall, F. (2018) Management of Thrombosis in Children and Neonates: Practical Use of Anticoagulants in Children. Hematology, ASH Education Pro-gram, 2018, 399-404. [Google Scholar] [CrossRef] [PubMed]
[33] 刘芳, 唐筱婉, 郑月宏, 等. 直接口服抗凝药在儿童患者中的应用进展[J]. 中国药学杂志, 2022, 57(16): 1323-1328.
[34] Jaffray, J. and Young, G. (2022) Direct Oral Anti-coagulants for Use in Paediatrics. The Lancet Child & Adolescent Health, 6, 207-214. [Google Scholar] [CrossRef
[35] Choueiter, N.F. (2022) Advancing Anticoagulation for Chil-dren with Cardiac Disease. Journal of the American College of Cardiology, 80, 2311-2313. [Google Scholar] [CrossRef] [PubMed]
[36] Portman, M.A., Jacobs, J.P., Newburger, J.W., et al. (2022) Edox-aban for Thromboembolism Prevention in Pediatric Patients with Cardiac Disease. Journal of the American College of Cardiology, 80, 2301-2310. [Google Scholar] [CrossRef] [PubMed]