海露联合人表皮生长因子滴眼液治疗飞行人员干眼症的疗效分析

Analysis of the Curative Effect of Sea Dew Combined with Human Epidermal Growth Factor Eye Drops in the Treatment of Dry Eye in Flight Personnel

摘要: 目的：分析海露联合重组人表皮生长因子滴眼液对飞行人员干眼症的治疗效果。方法：选取2021年1月~2022年12月于我中心保健疗养的被诊断为干眼症的部队飞行人员120例(240眼)，随机分为观察组与对照组各60例(120眼)，排除眼表其他炎症。对照组给予海露滴眼液治疗，观察组给予海露联合重组人表皮生长因子滴眼液治疗，用药30天，每天四次，每次1滴。结果：治疗后观察组与对照组的显效率分别为91.3%和78.6%，观察组的显效率明显高于对照组(P < 0.05)。治疗后观察组、对照组的非接触泪膜破裂时间(non-invasive break-up time, NIKBUT)分别为(13.36 ± 2.05) s、(10.49 ± 1.23) s，泪河高度(tear meniscus height, TMH)分别为(0.42 ± 0.07) mm、(0.31 ± 0.11) mm，脂质层厚度(Lipid layer thickness, LLT, 0~100 nm)分别为(81.78 ± 5.06) nm、(61.95 ± 6.37) nm。两组比较差异均有统计学意义(P < 0.05)。治疗后观察组、对照组的角膜荧光素染色(fluorescent, FL)评分分别为(0.54 ± 0.19)分、(1.33 ± 0.18)分，存在统计学意义(P < 0.05)。结论：海露联合重组人表皮生长因子滴眼液治疗干眼症能促进泪膜的稳定性，患者主观感觉良好，疗效较好。

Abstract: Objective: To analyze the therapeutic effect of sea dew combined with recombinant human epider-mal growth factor eye drops on dry eye syndrome in flight personnel. Methods: A total of 120 pilots (240 eyes) who were diagnosed with dry eye in our center from January 2021 to December 2022 were selected and randomly divided into observation group and control group, 60 cases (120 eyes) in each group. Other ocular surface inflammation was excluded. The control group was treated with sea dew eye drops, while the observation group was treated with sea dew combined with recombi-nant human epidermal growth factor eye drops for 30 days, one drop each time, four times a day. Results: After treatment, the effective rate of observation group and control group was 91.3% and 78.6%, respectively, and the effective rate of observation group was significantly higher than that of control group (P < 0.05). After treatment, the non-invasive break-up time (NIKBUT) of the observa-tion group and the control group is (13.36 ± 2.05) s, (10.49 ± 1.23) s, and tear meniscus height (TMH) is (0.42 ± 0.07) mm and (0.31 ± 0.11) mm, respectively. Lipid layer thickness, LLT (0~100 nm) is (81.78 ± 5.06) nm and (61.95 ± 6.37) nm, respectively. The difference between the two groups was statistically significant (P < 0.05). After treatment, corneal fluorescein staining (FL) scores in the observation group and control group were (0.54 ± 0.19) and (1.33 ± 0.18), respective-ly, showing statistical significance (P < 0.05). Conclusion: Sea dew combined with recombinant hu-man epidermal growth factor eye drops in the treatment of dry eye can promote the stability of tear film, the patients feel good, and the efficacy is good.