血小板减少与早产儿视网膜病变的研究进展
Research Progress on the Association of Platelet Deficiency with Retinopathy of Prematurity
DOI: 10.12677/ACM.2023.13122617, PDF,   
作者: 程义明, 芦 起:重庆医科大学附属儿童医院新生儿诊疗中心,重庆
关键词: 早产儿视网膜病变血小板减少血管生成Retinopathy of Prematurity Platelet Deficiency Angiogenesis
摘要: 早产儿视网膜病变(retinopathy of prematurity, ROP)是发生在早产儿和低出生体重儿的视网膜血管增殖疾病,ROP的病理机制主要涉及视网膜血管发育不全和病理性新生血管形成。近年来研究发现血小板减少与严重早产儿视网膜病变的发生密切相关,本文针对血小板减少与早产儿视网膜病变的相关研究进展做一综述,为临床诊断与治疗ROP提供新的思考。
Abstract: Retinopathy of prematurity (ROP) is an abnormal proliferative disease of the retinal vasculature that occurs in preterm and low-birth-weight infants. The pathogenesis of ROP mainly involves reti-nal vascular hypoplasia and pathologic neovascularization. In recent years, it has been found that platelet deficiency is related to the severe retinopathy of prematurity. This review summarizes the current research on platelet deficiency and retinopathy of prematurity, and provides new insights for clinical diagnosis and treatment of ROP.
文章引用:程义明, 芦起. 血小板减少与早产儿视网膜病变的研究进展[J]. 临床医学进展, 2023, 13(12): 18617-18622. https://doi.org/10.12677/ACM.2023.13122617

参考文献

[1] Solebo, A.L., Teoh, L. and Rahi, J. (2017) Epidemiology of Blindness in Children. Archives of Disease in Childhood, 102, 853-857. [Google Scholar] [CrossRef] [PubMed]
[2] Fevereiro-Martins, M., Marques-Neves, C., Guimarães, H. and Bicho, M. (2023) Retinopathy of Prematurity: A Review of Pathophysiology and Signaling Pathways. Survey of Ophthalmology, 68, 175-210. [Google Scholar] [CrossRef] [PubMed]
[3] Tan, W., Li, B., Wang, Z., Zou, J., Jia, Y., Yoshida, S. and Zhou, Y. (2022) Novel Potential Biomarkers for Retinopathy of Prematurity. Frontiers in Medicine, 9, Article 840030. [Google Scholar] [CrossRef] [PubMed]
[4] Kim, S.J., et al. (2018) Retinopathy of Prematurity: A Review of Risk Factors and Their Clinical Significance. Survey of Ophthalmology, 63, 618-637. [Google Scholar] [CrossRef] [PubMed]
[5] Trzcionkowska, K., Groenendaal, F., Andriessen, P., et al. (2021) Risk Factors for Retinopathy of Prematurity in the Netherlands: A Comparison of Two Cohorts. Neonatology, 118, 462-469. [Google Scholar] [CrossRef] [PubMed]
[6] Laura, B.B., et al. (2023) Latest Trends in Retinopathy of Prematurity: Research on Risk Factors, Diagnostic Methods and Therapies. International Journal of General Medicine, 16, 937-949. [Google Scholar] [CrossRef
[7] Roberts, I., Stanworth, S. and Murray, N.A. (2008) Thrombocytopenia in the Neonate. Blood Reviews, 22, 173-186. [Google Scholar] [CrossRef] [PubMed]
[8] Cremer, M., Sallmon, H., Kling, P.J., Bührer, C. and Dame, C. (2016) Thrombocytopenia and Platelet Transfusion in the Neonate. Seminars in Fetal and Neonatal Medicine, 21, 10-18. [Google Scholar] [CrossRef] [PubMed]
[9] Chan, H., Cougnard-Grégoire, A., Korobelnik, J.F., et al. (2018) Screening for Retinopathy of Prematurity by Telemedicine in a Tertiary Level Neonatal Intensive Care Unit in France: Review of a Six-Year Period. Journal Français d’Ophtalmologie, 41, 926-932. [Google Scholar] [CrossRef] [PubMed]
[10] Good, W.V. (2020) Retinopathy of Prematurity Incidence in Chil-dren. Ophthalmology, 127, S82-S83. [Google Scholar] [CrossRef] [PubMed]
[11] Hellström, A., Smith, L.E.H. and Dammann, O. (2013) Reti-nopathy of Prematurity. The Lancet, 382, 1445-1457. [Google Scholar] [CrossRef
[12] Sarlos, S., Rizkalla, B., Moravski, C.J., et al. (2003) Retinal Angiogenesis Is Mediated by an Interaction between the Angiotensin Type 2 Receptor, VEGF, and Angiopoietin. The American Journal of Pathology, 163, 879-887. [Google Scholar] [CrossRef
[13] Vinekar, A., Hegde, K., Gilbert, C., et al. (2010) Do Platelets Have a Role in the Pathogenesis of Aggressive Posterior Retinopathy of Prematurity? Retina, 30, S20-S23. [Google Scholar] [CrossRef
[14] Jensen, A.K., Ying, G., Huang, J., et al. (2018) Longitudinal Study of the Association between Thrombocytopenia and Retinopathy of Prematurity. Journal of AAPOS, 22, 119-123. [Google Scholar] [CrossRef] [PubMed]
[15] 陈鹤. 早产儿视网膜病变危险因素分析及发病预测模型研究[D]: [博士学位论文]. 广州: 南方医科大学, 2020.
[16] Tao, Y., Dong, Y., Lu, C.W. and Li, Q. (2015) Relationship between Mean Platelet Volume and Retinopathy of Prematurity. Graefe’s Archive for Clinical and Experimental Oph-thalmology, 253, 1791-1794. [Google Scholar] [CrossRef] [PubMed]
[17] Yüksel, H., Şahi̇n, A., Şahi̇n, M., et al. (2014) Mean Trombosit Volume in Patients with Retinopathy of Prematurity. Journal of Clinical and Experimental Investigations, 5, 276-279. [Google Scholar] [CrossRef
[18] Kaito, K., Otsubo, H., Usui, N., et al. (2005) Platelet Size De-viation Width, Platelet Large Cell Ratio, and Mean Platelet Volume Have Sufficient Sensitivity and Specificity in the Di-agnosis of Immune Thrombocytopenia. British Journal of Haematology, 128, 698-702. [Google Scholar] [CrossRef] [PubMed]
[19] Lundgren, P., Lundberg, L., Hellgren, G., et al. (2017) Aggressive Posterior Retinopathy of Prematurity Is Associated with Multiple Infectious Episodes and Thrombocytopenia. Neonatology, 111, 79-85. [Google Scholar] [CrossRef] [PubMed]
[20] Sancak, S., Toptan, H.H., Gokmen Yildirim, T., et al. (2019) Thrombocy-topeniaas a Risk Factor for Retinopathy of Prematurity. Retina, 39, 706-711. [Google Scholar] [CrossRef
[21] Cakir, B., Liegl, R., Hellgren, G., et al. (2018) Thrombocy-topenia Is Associated with Severe Retinopathy of Prematurity. JCI Insight, 3, e99448. [Google Scholar] [CrossRef] [PubMed]
[22] Rendu, F. and Brohard-bohn, B. (2001) The Platelet Release Reaction: Granules’ Constituents, Secretion and Functions. Platelets, 12, 261-273. [Google Scholar] [CrossRef] [PubMed]
[23] Andres, O., Schulze, H. and Speer, C.P. (2015) Platelets in Ne-onates: Central Mediators in Haemostasis, Antimicrobial Defence and Inflammation. Thrombosis and Haemostasis, 113, 3-12. [Google Scholar] [CrossRef
[24] PatzeltJ, F. and Langer, H. (2012) Platelets in Angiogenesis. Current Vascular Pharmacology, 10, 570-577. [Google Scholar] [CrossRef] [PubMed]
[25] Italiano, J.E., Richardson, J.L., Patel-Hett, S., et al. (2008) An-giogenesis Is Regulated by a Novel Mechanism: Pro- and Antiangiogenic Proteins Are Organized into Separate Platelet α Granules and Differentially Released. Blood, 111, 1227-1233 [Google Scholar] [CrossRef] [PubMed]
[26] Tan, W., Li, B., Wang, Z., Zou, J., Jia, Y., Yoshida, S. and Zhou, Y. (2022) Novel Potential Biomarkers for Retinopathy of Prematurity. Frontiers in Medicine, 9, Article 840030. [Google Scholar] [CrossRef] [PubMed]
[27] Jensen, A.K., Ying, G., Huang, J., et al. (2017) Postnatal Serum Insulin-Like Growth Factor i and Retinopathy of Prematurity. Retina, 37, 867-872. [Google Scholar] [CrossRef
[28] Pérez-Muñuzuri, A., Fernández-Lorenzo, J.R., Couce-Pico, M.L., Blanco-Teijeiro, M.J. and Fraga-Bermúdez, J.M. (2010) Serum Levels of IGF1 Are a Useful Predictor of Reti-nopathy of Prematurity. Acta Paediatrica, 99, 519-525. [Google Scholar] [CrossRef] [PubMed]
[29] Hellstrom, A., Perruzzi, C., Ju, M., et al. (2001) Low IGF-I Suppresses VEGF-Survival Signaling in Retinal Endothelial Cells: Direct Correlation with Clinical Retinopathy of Prematurity. Proceedings of the National Academy of Sciences of the United States of America, 98, 5804-5808. [Google Scholar] [CrossRef] [PubMed]
[30] Smith, L.E., Shen, W., Perruzzi, C., et al. (1999) Regulation of Vas-cular Endothelial Growth Factor-Dependent Retinal Neovascularization by Insulin-Like Growth Factor-1 Receptor. Na-ture Medicine, 5, 1390-1395. [Google Scholar] [CrossRef] [PubMed]
[31] Smith, L.E., Kopchick, J.J., Chen, W., et al. (1997) Essential Role of Growth Hormone in Ischemia-Induced Retinal Neovascularization. Science, 276, 1706-1709. [Google Scholar] [CrossRef] [PubMed]
[32] Smith, L.E.H. (2004) Pathogenesis of Retinopathy of Prema-turity. Growth Hormone & IGF Research, 14, 140-144. [Google Scholar] [CrossRef] [PubMed]
[33] Smith, W.J., Underwood, L.E., Keyes, L., et al. (1997) Use of In-sulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein Measurements to Monitor Feeding of Premature Infants. The Journal of Clinical Endocrinology and Metabolism, 82, 3982-3988. [Google Scholar] [CrossRef] [PubMed]
[34] Hellgren, G., Lundgren, P., Pivodic, A., et al. (2021) Decreased Platelet Counts and Serum Levels of VEGF-A, PDGF-BB, and BDNF in Extremely Preterm Infants Developing Severe Rop. Neonatology, 118, 18-27. [Google Scholar] [CrossRef] [PubMed]
[35] Heldin, C.H. and Westermark, B. (1999) Mechanism of Action and in vivo Role of Platelet-Derived Growth Factor. Physiological Reviews, 79, 1283-1316. [Google Scholar] [CrossRef] [PubMed]
[36] Betsholtz, C., Karlsson, L. and Lindahl, P. (2001) Develop-mental Roles of Platelet-Derived Growth Factors. BioEssays, 23, 494-507. [Google Scholar] [CrossRef] [PubMed]
[37] Hammes, H.P. (2005) Pericytes and the Pathogenesis of Diabetic Retinopa-thy. Hormone and Metabolic Research, 37, 39-43. [Google Scholar] [CrossRef] [PubMed]