难治性癫痫的治疗新进展

New Progress in the Treatment of Refractory Epilepsy

摘要: 癫痫是常见的脑疾病之一，目前全球有近7000万患者，其具有发作性、短暂性、重复性、刻板性等特点，并有脑功能减退和社会心理障碍等不良后果。大部分患者应用抗癫痫药物，可得到很好控制，但仍有30%患者对现有抗癫痫药物治疗无效，称为难治性癫痫(drug refractory epilepsy, DRE)。虽然难治性癫痫患者仅占所有癫痫患者的小部分，但是频繁严重的癫痫发作严重伤害了患者身体健康，造成患者生活质量低下，死亡率提高。同时，难治性癫痫也给家庭和社会带来了沉重的经济负担。故难治性癫痫的研究，近年来越来越成为癫痫学界的重点和热点。随着研究的进展，以及新的治疗技术的发现为控制难治性癫痫带来了良好的前景。本文就难治性癫痫目前的最新治疗方法加以综述。

Abstract: Epilepsy is one of the common brain diseases. There are nearly 70 million patients in the world, which has the characteristics of seizure, transient, repetitive, stereotypic, and has adverse conse-quences such as brain function decline and social psychological disorders. The majority of patients’ use of anti-epileptic drugs, can get very good control, but 30% of patients to the existing an-ti-epileptic drug treatment is invalid, called intractable epilepsy (drug refractory epilepsy, DRE). Although refractory epilepsy accounts for only a small proportion of all epilepsy patients, frequent and severe seizures seriously harm the health of patients, resulting in poor quality of life and in-creased mortality. At the same time, refractory epilepsy also brings a heavy economic burden to the family and society. Therefore, the study of refractory epilepsy has become the focus and hot spot in the field of epilepsy in recent years. With the progress of research, and the discovery of new treat-ment techniques for the control of refractory epilepsy, it has brought a good prospect. This article reviews the latest treatment methods of refractory epilepsy.