单纯疱疹病毒1型感染致Mollaret脑膜炎继发癫痫发作：1例报道并文献综述
Mollaret’s Meningitis with Secondary Seizure Caused by Herpes Simplex Virus Type 1: A Case Report and Literature Review
DOI: 10.12677/ACM.2023.13122638, PDF,   
作者: 赵燕红, 邢天丽, 滕继军*：青岛大学附属医院神经内科，山东 青岛；青岛大学医学院，山东 青岛；王澜静：首都医科大学宣武医院神经内科，北京；刘丽君：青岛大学附属医院神经内科，山东 青岛
关键词: Mollaret脑膜炎；良性复发性无菌性脑膜炎；单纯疱疹病毒1型；癫痫；Mollaret’s Meningitis； Benign Recurrent Aseptic Meningitis； Herpes Simplex Virus Type 1； Seizure
摘要: 目的：报告1例单纯疱疹病毒1型(Herpes simplex virus type 1, HSV-1)感染致Mollaret脑膜炎(Mollaret’s meningitis)继发癫痫发作的病例，旨在提高临床医生对该病的认识。方法：回顾性分析我院确诊的1例Mollaret脑膜炎患者的临床资料，并结合相关文献进行总结。结果：患者临床以反复发热伴头疼，及继发癫痫发作为特点，脑脊液二代测序(next-generation sequencing, NGS)检查发现HSV-1核酸序列阳性，诊断为Mollaret脑膜炎，经抗病毒及对症治疗1周后症状完全缓解。结论：Mollaret脑膜炎是临床少见疾病，由HSV-1感染更是少见，易误诊、漏诊，应提高早期识别率，减少不必要的检查及治疗。
Abstract: Objective: We aimed to report a case of Mollaret’s meningitis with secondary seizure caused by herpes simplex virus type 1, thereby improving clinicians’ understanding of this disease. Methods: The clinical data of a case of Mollaret’s meningitis were retrospectively analyzed, and discussed in combination with the literature. Results: The symptoms of this patient were characterized by re-current fever, headache and secondary seizure. The next-generation sequencing on cerebrospinal fluid detected positive HSV-1. In light of that, he was diagnosed as Mollaret’s meningitis, and his symptoms were completely relieved by antiviral and symptomatic treatment for about one week. Conclusion: Since Mollaret’s meningitis is a rare disease, especially caused by HSV-1, it is easy to be misdiagnosed and missed. Therefore, early identification of mollaret’s meningitis is particularly important for reducing unnecessary examinations and treatments.
文章引用：赵燕红, 王澜静, 刘丽君, 邢天丽, 滕继军. 单纯疱疹病毒1型感染致Mollaret脑膜炎继发癫痫发作：1例报道并文献综述[J]. 临床医学进展, 2023, 13(12): 18757-18762. https://doi.org/10.12677/ACM.2023.13122638

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