世居高海拔地区人群胆红素、超氧化物歧化酶与冠脉病变的相关性研究

Correlation of Bilirubin, Superoxide Dismutase and Coronary Artery Lesions in a Population Living at High Altitudes

摘要: 冠心病是中国中老年群体的常见死因之一，其病理生理基础是动脉粥样硬化，是全球心血管患者死亡的主要原因，近年来，随着对CHD不断深入研究发现，除了传统的危险因素外，氧化应激被认为是通过促进大分子损伤和内皮功能障碍而引起冠心病发生发展的重要组成部分。既往研究表明胆红素及超氧化物歧化酶具有抗氧化作用，其在静脉血清中的浓度水平与动脉粥样硬化程度相关。青海省特殊的高海拔低氧环境，会促进机体的氧化应激反应增加，氧化应激反应增加，可能会加重冠脉病变程度，但相关研究较少。本文就胆红素及超氧化物歧化酶在抗氧化作用及其与世居高海拔地区冠心病患者的冠脉病变中的关系进行综述，为临床防治高海拔地区冠心病提供参考。

Abstract: Coronary heart disease is one of the common causes of death in the middle-aged and elderly groups in China, and its pathogenesis is based on the lipid infiltration theory, retention response theory, vascular smooth muscle cloning theory, oxidative stress theory, Ca ion overload theory, and in-flammation theory. Among them, the roles of bilirubin and superoxide dismutase during oxidative stress have been gradually emphasized. In recent years, a large number of studies have shown that bilirubin and superoxide dismutase have antioxidant effects, and their concentration levels in ve-nous serum are related to the degree of atherosclerosis. The special high-altitude and low-oxygen environment in Qinghai Province promotes the increase of oxidative stress in the organism, and the increase of oxidative stress may aggravate the degree of coronary artery lesions, but there are fewer related studies. This paper reviews the role of bilirubin and superoxide dismutase in antioxidant and their relationship with coronary artery lesions in patients with coronary artery disease who live in high altitude areas, so as to provide reference for the clinical prevention and treatment of coro-nary artery disease in high altitude areas.