靶向HPV E5蛋白治疗宫颈癌的相关研究进展

Research Progress on Targeting HPV E5 Protein in the Treatment of Cervical Cancer

摘要: 宫颈癌发病率在全球范围内女性恶性肿瘤中位居第四位，是女性高发的恶性肿瘤之一，全球每年约有29万女性死于宫颈癌，是发展中国家女性癌症死亡的主要原因，宫颈癌好发于15~44岁年龄段的女性，近年来的数据表明宫颈癌的发生越来越年轻化。目前研究已经证明高危型HPV病毒持续感染是宫颈癌发生的重要诱因。HPV病毒能够逃脱宿主免疫清除是造成持续感染的重要原因，HPV E5蛋白在病毒免疫逃逸中发挥了重要作用。明确E5蛋白的作用，对于HPV感染的预防与治疗、避免宫颈癌前病变的进一步发展有重要意义，本文主要综述HPV E5蛋白协助HPV病毒逃避宿主免疫监控的机制及以E5蛋白为靶点治疗宫颈癌的研究进展。

Abstract: The incidence of cervical cancer ranks fourth among female malignant tumors in the world, and it is one of the most common malignant tumors in women. About 290,000 women die of cervical cancer every year, which is the main cause of cancer death among women in developing countries. Cervical cancer kills about 290,000 women worldwide every year, making it the leading cause of cancer death among women in developing countries. Cervical cancer is more common in women aged 15~44 years, and data from recent years show that cervical cancer is occurring at a younger age. At present, studies have proved that persistent infection of high-risk HPV virus is an important cause of cervical cancer. The ability of HPV virus to escape host immune clearance is an important cause of persistent infection, and HPV E5 protein plays an important role in viral immune escape. Clarifying the role of E5 protein is of great significance for the prevention and treatment of HPV infection and avoiding the further development of cervical precancerous lesions, and this article mainly reviews the mechanism of HPV E5 protein to assist HPV virus to evade host immune surveillance and the research progress of E5 protein as the target in the treatment of cervical cancer.